Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1986 • 1,709 citations

The distribution of tau in the mammalian central nervous system.

1985 • 1,518 citations

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

1986 • 1,387 citations

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease

1987 • 834 citations

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

1989 • 783 citations

Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.

1987 • 606 citations

A Neuronal Antigen in the Brains of Alzheimer Patients

1986 • 577 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

Ubiquitin-mediated protein degradation.

1988 • 453 citations

Isopeptide linkage between nonhistone and histone 2A polypeptides of chromosomal conjugate-protein A24.

1977 • 436 citations

Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology

1987 • 393 citations

Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments

1986 • 310 citations

Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease.

1989 • 255 citations

Histone 2B can be modified by the attachment of ubiquitin

1980 • 245 citations

Dephosphorylation of neurofilament proteins enhances their susceptibility to degradation by calpain

1988 • 232 citations

Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein.

1987 • 200 citations

Expression Cloning of a Lymphocyte Homing Receptor cDNA: Ubiquitin Is the Reactive Species

1986 • 163 citations

Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type

1989 • 136 citations

Ultrastructure of Paired Helical Filaments of Alzheimerʼs Neurofibrillary Tangle

1984 • 128 citations

Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences

1987 • 125 citations

Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments

1988 • 125 citations

Alz 50, a monoclonal antibody to Alzheimer's disease antigen, cross-reacts with tau proteins from bovine and normal human brain.

1988 • 107 citations

Alzheimer neurofibrillary tangles: Monoclonal antibodies to inherent antigen(s)

1984 • 106 citations

Alzheimer paired helical filaments: Immunochemical identification of polypeptides

1984 • 104 citations

Characterization of two pathological Tau protein variants in Alzheimer brain cortices

1989 • 100 citations

Microtubule-associated protein tau (? ) is a major antigenic component of paired helical filaments in Alzheimer disease

1987 • 99 citations

Tau Epitopes are Incorporated into a Range of Lesions in Alzheimerʼs Disease

1987 • 97 citations

Immunochemical and biochemical characterization of tau proteins in normal and Alzheimer's disease brains with Alz 50 and Tau-1.

1988 • 94 citations

Ubiquitin has intrinsic proteolytic activity: implications for cellular regulation.

1987 • 92 citations

Ubiquitin is a component of the microtubule network.

1988 • 88 citations

Immunochemical Properties of Ubiquitin Conjugates in the Paired Helical Filaments of Alzheimer Disease

1989 • 68 citations

Alzheimer's Disease and Related Disorders

1990 • 61 citations

Paired helical filaments and the cytoplasmic-nuclear interface in Alzheimer's disease

1988 • 48 citations

Alzheimer paired helical filaments: Identification of polypeptides with monoclonal antibodies

1985 • 40 citations

A modified form of microtubule-associated tau protein is the main component of paired helical filaments

1988 • 38 citations

Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to cross-reaction with tau protein

1987 • 22 citations

Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains

1987 • 19 citations

Ubiquitin: a multifunctional regulatory protein associated with the cytoskeleton.

1989 • 13 citations

Abnormally phosphorylated tau isolated from Alzheimer disease brain cytosol is not ubiquitinated

1990 • 2 citations

ALZHEIMER BRAIN PROTEINS (A68) AND HUMAN TAU SHARE EPITOPES BUT DIFFER IN pI AND PEPTIDE MAPS

1989 • 1 citations