Free radicals contribute to the reduction in peripheral vascular responses and the maintenance of thermal hyperalgesia in rats with chronic constriction injury

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1992 • 3,001 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury

1990 • 1,819 citations

Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation

1979 • 1,199 citations

Role of Oxidants in Ischemic Brain Damage

1996 • 1,037 citations

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.

1987 • 836 citations

Further evidence for ‘pain-related’ behaviours in a model of unilateral peripheral mononeuropathy

1990 • 504 citations

Nitric oxide neurotoxicity

1996 • 496 citations

Randomized, double-blind, vehicle-controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage: a cooperative study in Europe, Australia, and New Zealand

1996 • 398 citations

Free Radicals as Mediators of Tissue Injury

1991 • 386 citations

The Family of Protein Kinase C for Signal Transduction

1989 • 383 citations

Excitatory amino acid receptors, second messengers and regulation of intracellular Ca2+ in mammalian neurons

1990 • 355 citations

Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta

1988 • 193 citations

Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats

1995 • 182 citations

Inhibition of lipid peroxidation in central nervous system trauma and ischemia

1995 • 122 citations

A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy

1996 • 121 citations

Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs.

1991 • 120 citations

Chimeric NK1 (substance P)/NK3 (neurokinin B) receptors. Identification of domains determining the binding specificity of tachykinin agonists.

1993 • 99 citations

The nitric oxide-cyclic GMP pathway is required for nociceptive signalling at specific loci within the somatosensory pathway

1996 • 90 citations

Neuropathic pain in rats is associated with altered nitric oxide synthase activity in neural tissue

1996 • 90 citations

The use of salicylate hydroxylation to detect hydroxyl radical generation in ischemic and traumatic brain injury

1993 • 85 citations

Lipid peroxidation in experimental spinal cord injury: time-level relationship

1993 • 83 citations

Illness-induced hyperalgesia is mediated by a spinal NMDA-nitric oxide cascade

1994 • 71 citations

The Etiologic Role of Free Radicals in Hematoma-Induced Flap Necrosis

1986 • 71 citations

Illness-induced hyperalgesia is mediated by spinal neuropeptides and excitatory amino acids

1994 • 70 citations

Nitric oxide and sensory nerves are involved in the vasodilator response to acetylcholine but not calcitonin gene‐related peptide in rat skin micro vasculature

1992 • 70 citations

Application of nitric oxide synthase inhibitor, Nω-nitro-l-arginine methyl ester, on injured nerve attenuates neuropathy-induced thermal hyperalgesia in rats

1996 • 49 citations

Sequence of events in substance P-mediated plasma extravasation in rat skin

1989 • 45 citations

Intracerebroventricular administration of a nitric oxide-releasing compound, NOC-18, produces thermal hyperalgesia in rats

1995 • 43 citations

Effects of New 21-aminosteroid Tirilazad Mesylate (U74006F) on Chronic Cerebral Vasospasm in a “Two-Hemorrhage” Model of Beagle Dogs

1994 • 36 citations

Role of nitric oxide in the actions of substance P and other mediators of inflammation in rat skin microvasculature

1995 • 36 citations

Superoxide Dismutase Improves Posttraumatic Cortical Blood Flow in Rats

1995 • 35 citations

Serotonin modulates substance P-induced plasma extravasation and vasodilatation in rat skin by an action through capsaicin-sensitive primary afferent nerves

1990 • 34 citations

Skin vascular reactivity to the neuropeptide substance P in rats with peripheral mononeuropathy

1993 • 26 citations

Management of chronic pain

1993 • 25 citations

Secondary Ischaemia in Rabbit Skin Flaps: The Roles Played by Thromboxane and Free Radicals

1991 • 25 citations

Free Radical Damage in Acute Nerve Compression

1995 • 18 citations

Tachykinin-induced vasodilatation in rat skin measured with a laser-Doppler flowmeter: evidence for receptor-mediated effects

1989 • 14 citations

Oxygen free radicals regulate splanchnic nitric oxide synthesis and blood flow

1995 • 11 citations

Lewis rat EAN is suppressed by the 21–aminosteroid tirilazad mesylate (U–74006F)

1994 • 8 citations

Protective effects of tirilazad mesylate in a cellular model of peroxynitrite toxicity.

1996 • 8 citations