Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: Efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

1997 • 1,901 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

1993 • 1,655 citations

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

1994 • 1,579 citations

CLINICAL STUDIES WITH AN ARTICULAR INDEX FOR THE ASSESSMENT OF JOINT TENDERNESS IN PATIENTS WITH RHEUMATOID ARTHRITIS

1968 • 1,360 citations

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

1994 • 1,322 citations

Risk for Serious Gastrointestinal Complications Related to Use of Nonsteroidal Anti-inflammatory Drugs

1991 • 1,260 citations

Risk of Alzheimer's disease and duration of NSAID use

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Misoprostol Reduces Serious Gastrointestinal Complications in Patients with Rheumatoid Arthritis Receiving Nonsteroidal Anti-Inflammatory Drugs

1995 • 1,071 citations

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.

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Risk of upper gastrointestinal bleeding and perforation associated with Individual non-steroidal anti-inflammatory drugs

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The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

1990 • 940 citations

Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs

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New insights into the mode of action of anti-inflammatory drugs

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Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.

1992 • 823 citations

Indexes of Severity for Osteoarthritis of the Hip and Knee:Validation–Value in Comparison with Other Assessment Tests

1987 • 778 citations

Prostaglandin Endoperoxide H Synthases-1 and -2

1996 • 721 citations

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

1993 • 710 citations

Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice

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Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

1994 • 661 citations

Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis.

1996 • 576 citations

A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.

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Inverse association of anti‐inflammatory treatments and Alzheimer's disease

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Inhibition of platelet prostaglandin synthetase by oral aspirin.

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Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases.

1994 • 500 citations

Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts

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Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme.

1992 • 471 citations

Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.

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The Role of Arachidonic Acid Oxygenation Products in Pain and Inflammation

1984 • 457 citations

Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo.

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Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase

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Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene.

1992 • 412 citations

Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice.

1990 • 404 citations

Effects of Nonsteroidal Antiinflammatory Drugs on Platelet Function and Systemic Hemostasis

1995 • 354 citations

NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions

1993 • 348 citations

Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach.

1995 • 312 citations

Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease?

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A Seven‐Day variability study of 499 patients with peripheral rheumatoid arthritis

1965 • 237 citations

Index of severity for osteoarthritis of the hip and knee

1987 • 190 citations

Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid.

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The effects of ibuprofen, indomethacin, aspirin, naproxen, and placebo on the gastric mucosa of normal volunteers

1979 • 167 citations

Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1

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An endoscopic evaluation of the effects of non-steroidal anti-inflammatory drugs on the gastric mucosa

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Renal complications associated with use of nonsteroidal anti-inflammatory agents.

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1987 • 80 citations

A randomized, double-blind comparison of placebo, etodolac, and naproxen on gastrointestinal injury and prostaglandin production

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1984 • 57 citations

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