Convergent evolution of similar enzymatic function on different protein folds: The hexokinase, ribokinase, and galactokinase families of sugar kinases

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

1987 • 59,130 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

The Neutral Theory of Molecular Evolution

1979 • 7,965 citations

The Neutral Theory of Molecular Evolution

1983 • 6,141 citations

CLUSTAL V: improved software for multiple sequence alignment

1992 • 2,421 citations

Atomic structure of the actin: DNase I complex

1990 • 1,897 citations

Database of homology‐derived protein structures and the structural meaning of sequence alignment

1991 • 1,641 citations

Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein

1990 • 1,035 citations

Prosite: a dictionary of sites and patterns in proteins

1992 • 952 citations

An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins.

1992 • 805 citations

Sequence identification of 2,375 human brain genes

1992 • 764 citations

Mammalian phytogeny: shaking the tree

1992 • 656 citations

Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

1992 • 610 citations

Structure of Subtilisin BPN′ at 2.5 Å Resolution

1969 • 543 citations

The SWISS-PROT protein sequence data bank

1992 • 530 citations

Linkage of type 2 diabetes to the glucokinase gene

1992 • 386 citations

Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein.

1991 • 352 citations

Structure of a complex between yeast hexokinase A and glucose

1980 • 233 citations

Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.

1992 • 221 citations

A comparison of evolutionary rates of the two major kinds of superoxide dismutase

1992 • 167 citations

Molecular cloning, characterization, and nucleotide sequence of the tagatose 6-phosphate pathway gene cluster of the lactose operon of Lactococcus lactis.

1991 • 138 citations

Evolution and relatedness in two aminoacyl-tRNA synthetase families.

1991 • 127 citations

Glucose phosphorylation in tumor cells. Cloning, sequencing, and overexpression in active form of a full-length cDNA encoding a mitochondrial bindable form of hexokinase.

1990 • 118 citations

Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria.

1992 • 110 citations

Complete amino acid sequence of rat brain hexokinase, deduced from the cloned cDNA, and proposed structure of a mammalian hexokinase.

1989 • 110 citations

Structure of a complex between yeast hexokinase A and glucose

1980 • 108 citations

Human hexokinase: Sequences of amino- and carboxyl-terminal halves are homologous

1988 • 100 citations

Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase.

1991 • 96 citations

The complete sequence of the 8·2 kb segment left of MAT on chromosome III reveals five ORFs, including a gene for a yeast ribokinase

1990 • 96 citations

Xylose (glucose) isomerase gene from the thermophile Thermus thermophilus: cloning, sequencing, and comparison with other thermostable xylose isomerases

1991 • 95 citations

A new ATP-binding fold in actin, hexokinase and Hsc70

1993 • 90 citations

Isolation and characterization of the discrete N- and C-terminal halves of rat brain hexokinase: Retention of full catalytic activity in the isolated C-terminal half

1989 • 90 citations

Molecular cloning of the gene for phosphofructokinase-2 of Escherichia coli and the nature of a mutation, pfkB1, causing a high level of the enzyme

1983 • 89 citations

Nucleotide and deduced amino acid sequences of the lacR, lacABCD, and lacFE genes encoding the repressor, tagatose 6-phosphate gene cluster, and sugar-specific phosphotransferase system components of the lactose operon of Streptococcus mutans

1992 • 88 citations

New perspectives on evolution

1991 • 87 citations

Nucleotide sequence of the Rhodobacter capsulatus fruK gene, which encodes fructose-1-phosphate kinase: evidence for a kinase superfamily including both phosphofructokinases of Escherichia coli

1991 • 83 citations

Complete amino acid sequence of the type II isozyme of rat hexokinase, deduced from the cloned cDNA: Comparison with a hexokinase from novikoff ascites tumor

1991 • 83 citations

Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells

1991 • 80 citations

Molecular cloning of mevalonate kinase and regulation of its mRNA levels in rat liver.

1990 • 72 citations

Gene organization and structure of the Streptomyces lividans gal operon

1988 • 70 citations

Recognition of different nucleotide‐binding sites in primary structures using a property‐pattern approach

1990 • 58 citations

Molecular analysis of two fructokinases involved in sucrose metabolism of enteric bacteria

1991 • 57 citations

Complete amino acid sequence of the type III isozyme of rat hexokinase, deduced from the cloned cDNA

1991 • 57 citations

Human liver glucokinase gene: cloning and sequence determination of two alternatively spliced cDNAs.

1991 • 56 citations

Nucleotide sequence of the ERG12 gene of Saccharomyces cerevisiae encoding mevalonate kinase

1991 • 49 citations

Nucleotide sequence of gene pfkB encoding the minor phosphofructokinase of Escherichia coli K-12

1984 • 48 citations

Galactose utilization in Lactobacillus helveticus: isolation and characterization of the galactokinase (galK) and galactose-1-phosphate uridyl transferase (galT) genes

1991 • 47 citations

Cloning, sequencing, and expression of the Zymomonas mobilis fructokinase gene and structural comparison of the enzyme with other hexose kinases

1992 • 43 citations

Nucleotide sequence and analysis of the Vibrio alginolyticus sucrose uptake-encoding region

1990 • 43 citations

Sequence similarities between the gene specifying 1-phosphofructokinase ( fruK ), genes specifying other kinases in Escherichia coli K12, and lacC of Staphylococcus aureus

1990 • 38 citations

Cloning and sequencing the Lactobacillus brevis gene encoding xylose isomerase

1992 • 33 citations

Cloning of a human galactokinase gene (GK2) on chromosome 15 by complementation in yeast.

1992 • 32 citations

Mutations that increase the mitotic stability of minichromosomes in yeast: Characterization of RAR1

1987 • 29 citations

Cloning and Characterization of ERG8 an Essential Gene of Saccharomyces cerevisiae That Encodes Phosphomevalonate Kinase

1991 • 27 citations

The polypeptide chain molecular weight of a mammalian hexokinase

1971 • 26 citations

<scp>d</scp>-Xylose (<scp>d</scp>-glucose) isomerase from Arthrobacter strain N.R.R.L. B3728. Gene cloning, sequence and expression

1991 • 23 citations

Yeast homoserine kinase

1990 • 22 citations

Muscle glycerol kinase in Duchenne dystrophy and glycerol kinase deficiency

1989 • 19 citations

Sequence similarities between tryptophan synthase β subunit and other pyridoxal-phosphate-dependent enzymes

1990 • 19 citations

Cloning and characterization of the l-rhamnose regulon in Salmonella typhimurium LT2

1991 • 13 citations

Synthesis and characterization of a bovine hexokinase 1 cDNA probe by mixed oligonucleotide primed amplification of cDNA using high complexity primer mixtures

1989 • 8 citations