Cloning of a human galactokinase gene (GK2) on chromosome 15 by complementation in yeast.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis

1983 • 2,609 citations

A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance

1984 • 2,401 citations

The P-loop — a common motif in ATP- and GTP-binding proteins

1990 • 2,029 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

Mendelian Inheritance in Man. Catalogs of Autosomal Dominant, Autosomal Recessive, and X-Linked Phenotypes.

1967 • 1,002 citations

The Molecular Biology of the Yeast Saccharomyces (Metabolism and Gene Expression)

1985 • 712 citations

The organization and transcription of the galactose gene cluster of Saccharomyces

1981 • 350 citations

[23] Progressive alignment and phylogenetic tree construction of protein sequences

1990 • 350 citations

Mechanisms initiating cataract formation. Proctor Lecture.

1974 • 304 citations

ENZYMATIC EXPRESSION AND GENETIC LINKAGE OF GENES CONTROLLING GALACTOSE UTILIZATION IN SACCHAROMYCES

1964 • 271 citations

Assignment of the Gene for Myelin Proteolipid Protein to the X Chromosome: Implications for X-Linked Myelin Disorders

1985 • 213 citations

DEFICIENCY OF ERYTHROCYTE GALACTOKINASE IN A PATIENT WITH GALACTOSE DIABETES

1965 • 131 citations

Galactokinase encoded by GAL1 is a bifunctional protein required for induction of the GAL genes in Kluyveromyces lactis and is able to suppress the gal3 phenotype in Saccharomyces cerevisiae.

1991 • 121 citations

Regional mapping panel for human chromosome 17: Application to neurofibromatosis type 1

1987 • 120 citations

Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations.

1990 • 110 citations

Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae.

1991 • 107 citations

Analysis of the GAL3 signal transduction pathway activating GAL4 protein-dependent transcription in Saccharomyces cerevisiae.

1990 • 100 citations

Newborn screening for galactosemia and other galactose metabolic defects

1978 • 99 citations

Assignment of human 3-hydroxy-3-methylglutaryl coenzyme A reductase gene to q13 → q23 region of chromosome 5

1986 • 98 citations

Assignment of the gene for galactokinase to human chromosome 17 and its regional localisation to band q21-22

1974 • 96 citations

Yeast regulatory gene GAL3: carbon regulation; UASGal elements in common with GAL1, GAL2, GAL7, GAL10, GAL80, and MEL1; encoded protein strikingly similar to yeast and Escherichia coli galactokinases.

1988 • 94 citations

Variable numbers of pepsinogen genes are located in the centromeric region of human chromosome 11 and determine the high-frequency electrophoretic polymorphism.

1985 • 81 citations

Sequence of the Saccharomyces GAL region and its transcription in vivo

1984 • 78 citations

Structure of the galactokinase gene ofEscherichia coli, the last (?) gene of thegaloperon

1985 • 73 citations

Gene organization and structure of the Streptomyces lividans gal operon

1988 • 70 citations

A mouse-human hybrid cell panel for mapping human chromosome 16.

1986 • 67 citations

Monochromosomal rodent-human hybrids from microcell fusion of human lymphoblastoid cells containing an inserted dominant selectable marker

1990 • 62 citations

Cataracts, galactosuria and hypergalactosemia due to galactokinase deficiency in a child

1971 • 56 citations

PCR primers for human chromosomes: Reagents for the rapid analysis of somatic cell hybrids

1991 • 53 citations

Galactose utilization in Lactobacillus helveticus: isolation and characterization of the galactokinase (galK) and galactose-1-phosphate uridyl transferase (galT) genes

1991 • 47 citations

Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer.

1988 • 40 citations

Purification and Properties of Galactokinase from Human Red Blood Cells

1971 • 38 citations

Assignment of the human gene for galactokinase to chromosome 17

1974 • 31 citations

Galactokinase Encoded by GAL1 Is a Bifunctional Protein Required for Induction of the GAL Genes in Kluyveromyces lactis and Is Able To Suppress the gal3 Phenotype in Saccharomyces cerevisiae

1991 • 28 citations

Yeast Regulatory Gene GAL3: Carbon Regulation; UAS_Gal Elements in Common with GAL1, GAL2, GAL7, GAL10, GAL80, and MEL1; Encoded Protein Strikingly Similar to Yeast and Escherichia coli Galactokinases

1988 • 26 citations

Purification and kinetic properties of galactokinase from human placenta

1972 • 19 citations

Purification of human galactokinase and evidence for its existence as a monomer form

1985 • 11 citations

Isoelectric-focusing of galactokinase in lens and other tissues

1984 • 7 citations