Inflammatory Response to Cardiopulmonary Bypass

A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.

1992 • 727 citations

Preconditioning the human myocardium

1993 • 720 citations

Release of Inflammatory Mediators from Stimulated Neutrophils

1980 • 649 citations

Systemic inflammatory response syndrome after cardiac operations

1996 • 526 citations

Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium.

1993 • 490 citations

Heat-shock response is associated with enhanced postischemic ventricular recovery.

1988 • 489 citations

Heparin Bonding on Colloidal Graphite Surfaces

1963 • 452 citations

Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization

1994 • 423 citations

Aprotinin protects platelets against the initial effect of cardiopulmonary bypass

1990 • 380 citations

Fast-track recovery of the coronary bypass patient

1994 • 348 citations

Cardiopulmonary bypass induces leukocyte-platelet adhesion

1992 • 332 citations

Release of vasoactive substances during cardiopulmonary bypass

1992 • 327 citations

Complement activation and neutropenia occurring during cardiopulmonary bypass

1981 • 324 citations

Cytokine and complement levels in patients undergoing cardiopulmonary bypass

1993 • 314 citations

Human Pulmonary Circulation Is an Important Site for Both Clearance and Production of Endothelin-1

1996 • 301 citations

High-volume, Zero-balanced Hemofiltration to Reduce Delayed Inflammatory Response to Cardiopulmonary Bypass in Children

1996 • 283 citations

Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion of dogs.

1993 • 274 citations

Cytokine Responses to Cardiopulmonary Bypass: Lessons Learned From Cardiac Transplantation

1997 • 265 citations

Intestinal Permeability, Gastric Intramucosal pH, and Systemic Endotoxemia in Patients Undergoing Cardiopulmonary Bypass

1996 • 261 citations

Myocardium is a major source of proinflammatory cytokines in patients undergoing cardiopulmonary bypass

1996 • 261 citations

Reduced complement activation with heparin-coated oxygenator and tubings in coronary bypass operations

1992 • 255 citations

Hemofiltration during Cardiopulmonary Bypass in Pediatric Cardiac Surgery

1994 • 255 citations

Heparin-coated circuits reduce the inflammatory response to cardiopulmonary bypass

1993 • 251 citations

Leukocyte depletion ameliorates free radical-mediated lung injury after cardiopulmonary bypass

1990 • 251 citations

A prospective randomized study of a modified technique of ultrafiltration during pediatric open-heart surgery.

1991 • 251 citations

Aprotinin and methylprednisolone equally blunt cardiopulmonary bypass–induced inflammation in humans

1995 • 249 citations

Effects of Protamine Administration after Cardiopulmonary Bypass on Complement, Blood Elements, and the Hemodynamic State

1986 • 247 citations

Endotoxin release and tumor necrosis factor formation during cardiopulmonary bypass

1992 • 239 citations

Aprotinin inhibits the contact, neutrophil, and platelet activation systems during simulated extracorporeal perfusion

1993 • 233 citations

Role of platelet-activating factor in ischemia/reperfusion-induced leukocyte adherence

1990 • 226 citations

Inhibition by dexamethasone of the reperfusion phenomena in cardiopulmonary bypass

1991 • 210 citations

Endothelins and the lung.

1996 • 196 citations

Inhaled nitric oxide in the treatment of postoperative graft dysfunction after lung transplantation

1994 • 193 citations

Pattern of Injury and the Role of Neutrophils in Reperfusion Injury of Rat Lung

1995 • 192 citations

Human cytokine responses to cardiac transplantation and coronary artery bypass grafting

1996 • 189 citations

Association between gastric intramucosal pH and splanchnic endotoxin, antibody to endotoxin, and tumor necrosis factor-α concentrations in patients undergoing cardiopulmonary bypass

1993 • 188 citations

Endotoxemia associated with cardiopulmonary bypass

1987 • 185 citations

Complement activation during cardiopulmonary bypass in infants and children

1993 • 182 citations

Leukocyte depletion results in improved lung function and reduced inflammatory response after cardiac surgery

1996 • 181 citations

The Effects of Complement Activation During Cardiopulmonary Bypass

1988 • 179 citations

Corticosteroids increase blood interleukin-10 levels during cardiopulmonary bypass in men

1996 • 178 citations

Cytokine production and hemofiltration in children undergoing cardiopulmonary bypass

1993 • 176 citations

Reduced complement and granulocyte activation with heparin-coated cardiopulmonary bypass

1994 • 167 citations

The inflammatory profile of interleukin-6, interleukin-8, and soluble intercellular adhesion molecule-1 in postinjury multiple organ failure

1996 • 163 citations

Aprotinin in perspective

1993 • 160 citations

Nitric oxide: An overview

1995 • 155 citations

Induction of nitric oxide synthase gene by interleukin-1 beta in cultured rat cardiocytes.

1994 • 154 citations

The role of the gut in the development of multiple organ dysfunction in cardiothoracic patients

1993 • 150 citations

Cardiopulmonary bypass impairs small intestinal transport and increases cut permeability

1993 • 150 citations

Surface-bound heparin fails to reduce thrombin formation during clinical cardiopulmonary bypass

1996 • 149 citations

Ischemic preconditioning in cardiac surgery: A word of caution

1996 • 149 citations

A potential mechanism of vasodilation after warm heart surgery: The temperature-dependent release of cytokines

1994 • 143 citations

Heparin-bonded circuits with a reduced anticoagulation protocol in primary CABG: a prospective, randomized study

1996 • 142 citations

The Effect of Cardiopulmonary Bypass on Intestinal and Pulmonary Endothelial Permeability

1995 • 141 citations

Very-low-dose inhaled nitric oxide: A selective pulmonary vasodilator after operations for congenital heart disease

1994 • 140 citations

Presence of circulating endotoxins during cardiac operations

1987 • 139 citations

Evidence for complement activation by protamine-heparin interaction after cardiopulmonary bypass.

1985 • 136 citations

Influence of steroids on complement and cytokine generation after cardiopulmonary bypass

1995 • 136 citations

Steroid Inhibition of Cytokine-Mediated Vasodilation After Warm Heart Surgery

1995 • 135 citations

Efficacy of ultrafiltration in removing inflammatory mediators during pediatric cardiac operations

1996 • 132 citations

Impact of left ventricular dysfunction on cytokines, hemodynamics, and outcome in bypass grafting

1996 • 130 citations

Biocompatibility of extracorporeal circulation

1991 • 129 citations

Induction of Nitric Oxide Synthase Activity by Cytokines in Ventricular Myocytes Is Necessary but Not Sufficient to Decrease Contractile Responsiveness to β-Adrenergic Agonists

1995 • 128 citations

Completely heparinized cardiopulmonary bypass and reduced systemic heparin: Clinical and hemostatic effects

1995 • 127 citations

Heparin-coated circuits reduce activation of granulocytes during cardiopulmonary bypass

1992 • 126 citations

Heparin bonding of bypass circuits reduces cytokine release during cardiopulmonary bypass

1995 • 123 citations

Reduction and elimination of systemic heparinization during cardiopulmonary bypass

1992 • 120 citations

Reduced complement activation and improved postoperative performance after cardiopulmonary bypass with heparin-coated circuits

1995 • 120 citations

Complement activation during major operations with or without cardiopulmonary bypass

1987 • 117 citations

Risk and benefit of low systemic heparinization during open heart operations

1994 • 116 citations

Interleukin-8 Production in Patients Undergoing Cardiopulmonary Bypass: The Influence of Pretreatment with Methylprednisolone

1993 • 116 citations

Neutrophil adhesion molecule expression during cardiopulmonary bypass with bubble and membrane oxygenators

1993 • 115 citations

Oxygen free radical generation during cardiopulmonary bypass: correlation with complement activation.

1986 • 114 citations

Heparin-coated bypass circuits reduce pulmonary injury

1993 • 112 citations

Interleukin-6 administration has no acute hemodynamic or hematologic effect in the dog

1991 • 108 citations

The role of different types of corticosteroids on the inflammatory mediators in cardiopulmonary bypass

1991 • 107 citations

Inhibition of neutrophil adhesion during cardiopulmonary bypass

1994 • 106 citations

Gut mucosal ischemia during normothermic cardiopulmonary bypass results from blood flow redistribution and increased oxygen demand

1995 • 105 citations

Antibody against leukocyte integrin (CD18) prevents reperfusion-induced lung vascular injury

1990 • 104 citations

Heat shock. A new approach for myocardial preservation in cardiac surgery.

1992 • 104 citations

Endotoxemia and enhanced generation of oxygen radicals by neutrophils from patients undergoing cardiopulmonary bypass

1989 • 104 citations

Increased oxygen free radical activity in patients on cardiopulmonary bypass undergoing aortocoronary bypass surgery

1992 • 103 citations

Complement activation and lung permeability during cardiopulmonary bypass

1990 • 100 citations

Pretreatment with antioxidants and allopurinol diminishes cardiac onset events in coronary artery bypass grafting

1995 • 98 citations

Effect of polymorphonuclear leukocyte-derived oxygen free radicals and hypochlorous acid on cardiac function and some biochemical parameters

1990 • 98 citations

Interleukin-1 alpha preconditioning reduces myocardial ischemia reperfusion injury.

1993 • 97 citations

Low output syndrome

1969 • 94 citations

Effect of methylprednisolone on endotoxemia and complement activation during cardiac surgery

1989 • 93 citations

Evidence of organ damage after cardiopulmonary bypass. The role of elastase and vasoactive mediators.

1992 • 93 citations

Elevated levels of plasma endothelin-1 in young patients with pulmonary hypertension caused by congenital heart disease are decreased after successful surgical repair

1995 • 89 citations

Complete prevention of myocardial stunning, contracture, low-reflow, and edema after heart transplantation by blocking neutrophil adhesion molecules during reperfusion

1992 • 88 citations

Lower cardiac troponin T levels in patients undergoing cardiopulmonary bypass and receiving high-dose aprotinin therapy indicate reduction of perioperative myocardial damage

1995 • 88 citations

Myocardial free-radical injury after cardioplegia.

1989 • 87 citations

Nitric oxide synthesis in cardiac myocytes and fibroblasts by inflammatory cytokines

1995 • 86 citations

Endotoxins in cardiopulmonary bypass

1990 • 86 citations

l-Arginine reduces endothelial inflammation and myocardial stunning during ischemia/reperfusion

1995 • 86 citations

Formation of C5a during cardiopulmonary bypass: Inhibition by precoating with heparin

1991 • 84 citations

Complement activation during cardiopulmonary bypass: Effects of immobilized heparin

1994 • 84 citations

Complement and neutrophil activation during cardiopulmonary bypass: A study in the complement-deficient dog

1994 • 83 citations

Influence of Temperature on Neutrophil Trafficking During Clinical Cardiopulmonary Bypass

1995 • 83 citations

Evaluation of leukocyte-depleted terminal blood cardioplegic solution in patients undergoing elective and emergency coronary artery bypass grafting

1994 • 82 citations

Use of Corticosteroids During Cardiopulmonary Bypass: Possible Lysosome Stabilization

1966 • 82 citations

Molecular evidence for induction of intracellular adhesion molecule-1 in the viable border zone associated with ischemia-reperfusion injury of the dog heart.

1994 • 82 citations

Assessment of myocardial oxidative stress in patients after myocardial revascularization

1988 • 82 citations

Heparin coating of an extracorporeal circuit partly improves hemostasis after cardiopulmonary bypass

1994 • 82 citations

Influence of Duraflo II heparin-treated extracorporeal circuits on the systemic inflammatory response in patients having coronary bypass

1995 • 80 citations

The influence of leukocyte filtration during cardiopulmonary bypass on postoperative lung function: A clinical study

1995 • 79 citations

Hypothermia During Cardiopulmonary Bypass Delays but Does Not Prevent Neutrophil– Endothelial Cell Adhesion

1995 • 78 citations

Studies of controlled reperfusion after ischemia. XXI. Reperfusate composition: superiority of blood cardioplegia over crystalloid cardioplegia in limiting reperfusion damage--importance of endogenous oxygen free radical scavengers in red blood cells.

1991 • 78 citations

Hepatic release of interleukin-10 during cardiopulmonary bypass in steroid-pretreated patients

1997 • 78 citations

Complement and granulocyte activation in two different types of heparinized extracorporeal circuits

1995 • 76 citations

Methylprednisolone inhibits increase of interleukin 8 and 6 during open heart surgery

1995 • 76 citations

A clinical study on the effects of pulsatile cardiopulmonary bypass on the blood endotoxin levels

1994 • 76 citations

Deferoxamine cardioplegia reduces superoxide radical production in human myocardium

1995 • 74 citations

Endothelium, coronary vasodilation, and organic nitrates

1995 • 73 citations

Effects on Coagulation and Fibrinolysis With Reduced Versus Full Systemic Heparinization and Heparin-Coated Cardiopulmonary Bypass

1995 • 73 citations

Pathophysiology of Cardiopulmonary Bypass: Current Issues

1990 • 73 citations

Regulatory effects of interleukin-10 on lung ischemia-reperfusion injury

1996 • 73 citations

Depletion of plasma vitamin C but not of vitamin E in response to cardiac operations

1994 • 72 citations

Leukocyte activation with increased expression of CR3 receptors during cardiopulmonary bypass

1992 • 72 citations

Neutrophil Sequestration and Pulmonary Dysfunction in a Canine Model of Open Heart Surgery With Cardiopulmonary Bypass

1995 • 72 citations

Leukocyte depletion results in excellent heart-lung function after 12 hours of storage

1990 • 72 citations

Myocardial performance in elderly patients after cardiopulmonary bypass is suppressed by tumor necrosis factor

1995 • 71 citations

Glucocorticoid reduction of bronchial epithelial inflammation during cardiopulmonary bypass.

1995 • 70 citations

Drug-Induced Heat-Shock Preconditioning Improves Postischemic Ventricular Recovery After Cardiopulmonary Bypass

1995 • 70 citations

Neutrophils are not necessary for ischemia-reperfusion lung injury

1992 • 69 citations

Evidence of organ damage after cardiopulmonary bypass

1992 • 69 citations

Global myocardial ischemia and reperfusion impair endothelium-dependent relaxations to aggregating platelets in the canine coronary artery

1992 • 68 citations

Myocardial free-radical injury after cardioplegia.

1989 • 67 citations

Effects of Glucocorticosteriods in Patients Undergoing Coronary Artery Bypass Surgery

1979 • 67 citations

High and low heparin dose with heparin-coated cardiopulmonary bypass: Activation of complement and granulocytes

1995 • 66 citations

Does Cardiopulmonary Bypass Alone Elicit Myoprotective Preconditioning?

1995 • 65 citations

Cardiopulmonary bypass without systemic heparinization Performance of heparin-coated oxygenators in comparison with classic membrane and bubble oxygenators

1989 • 65 citations

Studies of controlled reperfusion after ischemia

1991 • 65 citations

Beneficial effects of duraflo II heparin-coated circuits on postperfusion lung dysfunction

1996 • 64 citations

Systemic pattern of free radical generation during coronary bypass surgery.

1990 • 63 citations

Specific complement inhibition with heparin-coated extracorporeal circuits

1996 • 62 citations

Preconditioning with potassium channel openers:

1995 • 62 citations

Myocardial reperfusion injury

1991 • 62 citations

Biocompatibility of heparin-coated extracorporeal bypass circuits: A randomized, masked clinical trial

1996 • 61 citations

Thromboxane A2 mediates pulmonary hypertension after cardiopulmonary bypass in the rabbit

1993 • 61 citations

Neutrophil activation and adhesion molecule expression in a canine model of open heart surgery with cardiopulmonary bypass.

1995 • 60 citations

Increased oxygen consumption after cardiac surgery is associated with the inflammatory response to endotoxemia

1996 • 59 citations

Steroid administration in heart and heart—lung transplantation: Is the timing adequate?

1996 • 59 citations

Leukocyte and platelet depletion with a blood cell separator: Effects on lung injury after cardiac surgery with cardiopulmonary bypass

1996 • 58 citations

Coenzyme Q10 protects coronary endothelial function from ischemia reperfusion injury via an antioxidant effect

1996 • 58 citations

The effects of methylprednisolone on complement-mediated neutrophil activation during cardiopulmonary bypass.

1986 • 57 citations

Free radical reaction products and antioxidant capacity in arterial plasma during coronary artery bypass grafting

1994 • 57 citations

Prostaglandin E1 infusion for right ventricular failure after cardiac transplantation

1992 • 56 citations

Time-course of free radical activity during coronary artery operations with cardiopulmonary bypass.

1993 • 55 citations

Temporary leukocyte depletion reduces ventricular dysfunction during prolonged postischemic reperfusion

1993 • 54 citations

Influence of low-dose aprotinin on the inflammatory reaction due to cardiopulmonary bypass in children

1996 • 53 citations

Vitamin E for coronary bypass operations. A prospective, double-blind, randomized trial.

1994 • 53 citations

Effects of l-Arginine and l-nitro-arginine methyl ester on recovery of neonatal lamb hearts after cold ischemia

1995 • 53 citations

Complement, leukocytes, and leukocyte elastase in full-term neonates undergoing cardiac operation

1994 • 53 citations

Time-course of free radical activity during coronary artery operations with cardiopulmonary bypass

1993 • 51 citations

Does normothermia during cardiopulmonary bypass increase neutrophil-endothelium interactions?

1994 • 51 citations

Vitamin E for coronary bypass operations

1994 • 51 citations

Effects of inflammatory cytokines on vascular tone

1995 • 50 citations

Oxygen radical-mediated vascular injury selectively inhibits receptor-dependent release of nitric oxide from canine coronary arteries.

1994 • 50 citations

Platelet activating factor inhibition reduces lung injury after cardiopulmonary bypass

1995 • 49 citations

The effects of carmeda bioactive surface on human blood components during simulated extracorporeal circulation

1996 • 48 citations

Free radical—mediated vascular injury in lungs preserved at moderate hypothermia

1995 • 47 citations

Endotoxemia, complement, and white blood cell activation in cardiac surgery: A randomized trial of laxatives and pulsatile perfusion

1994 • 47 citations

Plasma antioxidant depletion after cardiopulmonary bypass in operations for congenital heart disease

1995 • 46 citations

Heparin-coated circuits and aprotinin prime for coronary artery bypass grafting

1996 • 45 citations

Perfusion-related factors of endotoxin release during cardiopulmonary bypass

1994 • 45 citations

Oxygen radical—mediated vascular injury selectively inhibits receptor-dependent release of nitric oxide from canine coronary arteries

1994 • 44 citations

Nitric oxide synthesis in cardiac myocytes and fibroblasts by inflammatory cytokines

1995 • 44 citations

Impaired endothelium-dependent relaxation after coronary reperfusion injury: Evidence for G-protein dysfunction

1994 • 43 citations

Defining the Role of Aprotinin in Heart Transplantation

1996 • 43 citations

Endothelin-1–Induced Release of Thromboxane A ₂ Increases the Vasoconstrictor Effect of Endothelin-1 in Postischemic Reperfused Rat Hearts

1996 • 42 citations

Disparity in blood activation by two different heparin-coated cardiopulmonary bypass systems

1995 • 42 citations

Circulating endothelin in patients undergoing coronary artery bypass grafting

1995 • 42 citations

The use of methylprednisolone during cardiopulmonary bypass

1975 • 41 citations

Reduction in surgical ischemic-reperfusion injury with adenosine and nitric oxide therapy

1995 • 40 citations

Heparin and protamine stimulate the production of nitric oxide.

1996 • 40 citations

Aprotinin modulation of platelet activation in patients undergoing cardiopulmonary bypass operations

1996 • 40 citations

Circulating endothelin in cardiac operations: influence of blood pressure and endotoxin

1996 • 39 citations

Does aprotinin increase the myocardial damage in the setting of ischemia and preconditioning?

1995 • 38 citations

Aprotinin improves myocardial recovery after ischemia and reperfusion:

1994 • 38 citations

Clinical experience with heparin-coated cardiopulmonary bypass circuits

1991 • 38 citations

Adenosine and PAF dependent mechanisms lead to myocardial reperfusion injury by neutrophils after brief ischaemia

1995 • 37 citations

Prostacyclin in cardiopulmonary bypass operations

1982 • 37 citations

NITRIC OXIDE DONORS IMPROVE GUT FUNCTION AFTER PROLONGED HYPOTHERMIC ISCHEMIA

1995 • 36 citations

Platelet-activating factor plays an important role in reperfusion injury in myocardium

1994 • 35 citations

Effect of heparin anticoagulation on neutrophil adhesion molecules and release of IL8: C3 is not essential

1995 • 35 citations

Biocompatibility of Heparin‐Coated Membrane Oxygenator During Cardiopulmonary Bypass

1994 • 35 citations

Neutrophil leukotriene generation increases after cardiopulmonary bypass

1994 • 35 citations

RETRACTED: Circulating adhesion molecules in cardiac operations: Influence of high-dose aprotinin

1995 • 34 citations

Effect of methylprednisolone on myocardial preservation during coronary artery surgery

1976 • 33 citations

Aprotinin improves myocardial recovery after ischemia and reperfusion. Effects of the drug on isolated rat hearts.

1994 • 33 citations

Studies of controlled reperfusion after ischemia. XXII. Reperfusate composition: effects of leukocyte depletion of blood and blood cardioplegic reperfusates after acute coronary occlusion.

1991 • 32 citations

Evidence of cardiac inflammation after open heart operations

1994 • 31 citations

Ultrafiltration after cardiopulmonary bypass in children: effects on hemodynamics, cytokines and complement

1996 • 30 citations

Plasma endothelin levels and surgically correctable pulmonary hypertension

1993 • 29 citations

Increased levels of endothelin-1 in bronchoalveolar lavage fluid of patients with lung allografts

1996 • 29 citations

Endothelin-1 focally constricts pulmonary veins in rats

1995 • 29 citations

Neutrophil activation and adhesion molecule expression in a canine model of open heart surgery with cardiopulmonary bypass

1995 • 29 citations

Role of leukocyte depletion during cardiopulmonary bypass and cardioplegic arrest

1995 • 28 citations

Leukocyte depletion in a neonatal model of cardiac surgery

1993 • 28 citations

Pulmonary injury after total or partial cardiopulmonary bypass with thromboxane synthesis inhibition

1995 • 28 citations

Ca(2+)-independent nitric oxide synthase activity in human lung after cardiopulmonary bypass.

1995 • 27 citations

Clinical cardiopulmonary bypass without systemic anticoagulation

1993 • 25 citations

Regional generation of free oxygen radicals during cardiopulmonary bypass in children

1995 • 25 citations

Studies of controlled reperfusion after ischemia

1991 • 25 citations

A Heparin‐Coated Circuit Reduces Complement Activation and the Release of Leukocyte Inflammatory Mediators During Extracorporeal Circulation in a Rabbit

1992 • 25 citations

Coronary vasoconstriction mediated by endothelin-1 in neonates: Reversal by nitroglycerin

1995 • 24 citations

Acute endothelial reperfusion injury after coronary artery bypass grafting

1994 • 22 citations

Pulmonary failure and the production of leukotrienes.

1994 • 22 citations

Regulation of pulmonary vascular resistance by endogenous and exogenous nitric oxide

1994 • 21 citations

Mechanisms of brain injury with deep hypothermic circulatory arrest and protective effects of coenzyme Q10

1994 • 21 citations

Treatment of acute pulmonary hypertension with inhaled nitric oxide

1994 • 20 citations

Aprotinin improves hemostasis after cardiopulmonary bypass better than single-donor platelet concentrate

1995 • 20 citations

Cardiac-derived thromboxane A2

1993 • 20 citations

Prevention of complement-induced pulmonary hypertension and improvement of right ventricular function by selective thromboxane receptor antagonism

1994 • 20 citations

Cardiopulmonary bypass, myocardial management, and support techniques Changes in autonomic response of the cerebral circulation after normothermic extracorporeal circulation

1996 • 20 citations

The dynamic change of plasma endothelin-1 during the perioperative period in patients with rheumatic valvular disease and secondary Pulmonary hypertension

1994 • 19 citations

Effects of inflammatory cytokines on vascular tone

1995 • 19 citations

Accelerated recovery of postischemic stunned myocardium after induced expression of myocardial heat-shock protein (HSP70)

1995 • 18 citations

Efficacy of leukocyte filters in the bypass circuit for infants undergoing cardiac operations

1995 • 18 citations

Complement activation during prolonged extracorporeal membrane oxygenation.

1991 • 18 citations

Steroids and myocardial preservation

1977 • 18 citations

Influence of temporary faecal diversion on long-term survival after curative surgery for colorectal cancer

1995 • 18 citations

Myocardial protective effect and its mechanism of leukocyte-depleted reperfusion in neonatal rabbit hearts

1994 • 17 citations

Plasma endothelin and early coronary endothelial dysfunction in recipients of a cardiac transplant

1995 • 16 citations

Biocompatibility of a heparin-bonded membrane oxygenator (Carmeda MAXIMA) during the first 90 minutes of cardiopulmonary bypass: clinical comparison with the conventional system.

1994 • 16 citations

Effects of endothelin-1 and l-arginine after cold ischemia in lamb hearts

1996 • 16 citations

Improved recovery of heart transplants by combined use of oxygen-derived free radical scavengers and energy enhancement

1992 • 15 citations

Clinical application of heparin-coated perfusion equipment with special emphasis on patients refusing homologous transfusions

1991 • 15 citations

Safe use of heparin-coated bypass circuits incorporating a pump-oxygenator

1994 • 15 citations

Adenosine and PAF dependent mechanisms lead to myocardial reperfusion injury by neutrophils after brief ischaemia

1995 • 14 citations

Thromboxane A2 receptor-specific antagonism in hypothermic cardiopulmonary bypass

1994 • 13 citations

Ultrafiltration after cardiopulmonary bypass in children: effects on hemodynamics, cytokines and complement

1996 • 13 citations

Is the heart a source for elevated circulating endothelin levels during aorta—coronary artery bypass grafting surgery in human beings?

1996 • 12 citations

Failure of methylprednisolone to protect myocardial function or prevent myocardial edema following ischemic cardiac arrest

1978 • 10 citations

Perioperative alteration of neutrophil functions after open heart and other major surgeries. A comparative study.

1989 • 9 citations

Prostaglandin E1 (PGE1) reduces cardiac-derived TXA2 release in ischaemic arrest in isolated working rat heart

1996 • 8 citations

Prostacyclin and thromboxane levels in pleural space fluid during cardiopulmonary bypass

1995 • 8 citations

Complement activation during prolonged extracorporeal membrane oxygenation

1992 • 7 citations

Absence of complement-mediated events after protamine reversal of heparin anticoagulation

1991 • 4 citations

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