Pathophysiology of Cardiopulmonary Bypass: Current Issues

Complement and the damaging effects of cardiopulmonary bypass

1983 • 1,360 citations

EFFECT OF APROTININ ON NEED FOR BLOOD TRANSFUSION AFTER REPEAT OPEN-HEART SURGERY

1987 • 696 citations

Effect of Heparin and Heparin Fractions on Platelet Aggregation

1980 • 607 citations

Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol)

1989 • 544 citations

Heparin-Associated Thrombocytopenia

1984 • 498 citations

Complement activation and neutropenia occurring during cardiopulmonary bypass

1981 • 324 citations

A new technique for hemodilution, preparation of autologous platelet-rich plasma and intraoperative blood salvage in cardiac surgery

1987 • 270 citations

HEPARIN-INDUCED THROMBOCYTOPENIA: ASSOCIATION OF THROMBOTIC COMPLICATIONS WITH HEPARIN-DEPENDENT IgG ANTIBODY THAT INDUCES THROMBOXANE SYNTHESIS AND PLATELET AGGREGATION

1982 • 251 citations

Effects of Protamine Administration after Cardiopulmonary Bypass on Complement, Blood Elements, and the Hemodynamic State

1986 • 247 citations

Induction of interleukin-1 production in patients undergoing cardiopulmonary bypass

1989 • 247 citations

Association of Protamine IgE and IgG Antibodies with Life-Threatening Reactions to Intravenous Protamine

1989 • 202 citations

Human neutrophil degranulation during extracorporeal circulation

1987 • 194 citations

Complement activation during cardiopulmonary bypass

1986 • 180 citations

The Effects of Complement Activation During Cardiopulmonary Bypass

1988 • 179 citations

Increased production of peroxidation products associated with cardiac operations

1986 • 175 citations

Autologous Blood Donations Prior to Elective Cardiac Surgery

1989 • 159 citations

Enhanced fibrinolytic activity during cardiopulmonary bypass in open-heart surgery in man is caused by extrinsic (tissue-type) plasminogen activator

1984 • 156 citations

Formation of C1s-C1-inhibitor, kallikrein-C1-inhibitor, and plasmin- alpha 2-plasmin-inhibitor complexes during cardiopulmonary bypass

1989 • 146 citations

Evidence for complement activation by protamine-heparin interaction after cardiopulmonary bypass.

1985 • 136 citations

Evaluation of patients at risk for protamine reactions

1989 • 127 citations

An Enzymatic System for Removing Heparin in Extracorporeal Therapy

1982 • 125 citations

RETINAL MICROEMBOLISM DURING CARDIOPULMONARY BYPASS DEMONSTRATED BY FLUORESCEIN ANGIOGRAPHY

1986 • 125 citations

Autologous Platelet-Rich Plasma in Cardiac Surgery: Effect on Intraoperative and Postoperative Transfusion Requirements

1988 • 117 citations

Reduction of Homologous Blood Requirement in Cardiac Surgery by Intraoperative Aprotinin Application - Clinical Experience in 152 Cardiac Surgical Patients

1989 • 104 citations

Prospective Evaluation of Risk of Protamine Reactions in Patients with NPH Insulin-Dependent Diabetes

1986 • 98 citations

Reduction of Blood Transfusion Requirement in Open Heart Surgery by Administration of High Doses of Aprotinin - Preliminary Results

1989 • 90 citations

Intraoperative management of patients with heparin-induced thrombocytopenia

1990 • 85 citations

Deferoxamine reduces neutrophil-mediated free radical production during cardiopulmonary bypass in man

1988 • 83 citations

Platelet Aggregation Following Heparin and Protamine Administration

1978 • 79 citations

Complement activation during cardiopulmonary bypass

1980 • 73 citations

The use of Doppler ultrasound in the assessment of microemboli during cardiac surgery

1989 • 69 citations

Complement Activation in Cardiopulmonary Bypass, with Special Reference to Anaphylatoxin Production in Membrane and Bubble Oxygenators

1988 • 64 citations

Determinants of homologous blood usage utilizing autologous platelet-rich plasma in cardiac operations

1989 • 59 citations

Retinal microembolism and neuropsychological deficit following clinical cardiopulmonary bypass: comparison of a membrane and a bubble oxygenator *1A preliminary communication

1989 • 57 citations

In vivo complement activation by polyanion-polycation complexes: Evidence that C5a is generated intravascularly during heparin-protamine interaction

1983 • 39 citations

Anaphylactic/anaphylactoid reactions during cardiac surgery

1989 • 33 citations

Anaphylactic Reactions in Anesthesia and Intensive Care

1986 • 31 citations

Interventions to reduce cerebral injury during cardiac surgery-the effect of arterial line filtration

1989 • 30 citations

Autologous Blood Transfusion: Current Issues

1989 • 28 citations

Extracorporeal enzymatic heparin removal: Use in a sheep dialysis model

1987 • 26 citations

Autologous blood donations prior to elective cardiac surgery. Safety and effect on subsequent blood use

1989 • 24 citations

Pathophysiology and Techniques of Cardiopulmonary Bypass

1984 • 23 citations

Bubble Oxygenation and Cardiotomy Suction Impair the Host Defense during Cardiopulmonary Bypass: A Study in Dogs

1987 • 22 citations

The incidence and nature of neurological morbidity following cardiac surgery: a review

1989 • 19 citations

Effects of protamine on histamine release from human lung

1989 • 17 citations

Prevention of major perioperative neurological dysfunction—a personal perspective

1986 • 15 citations

PROGNOSTIC VALUE OF PREOPERATIVE NONINVASIVE DOPPLER MEASUREMENTS OF CARDIAC INDEX, A PILOT STUDY

1987 • 12 citations

Ex vivo model of an immobilized-enzyme reactor.

1988 • 10 citations

Left Atrial Injection of Protamine Does Not Reliably Prevent Pulmonary Hypertension

1987 • 8 citations

Does Plasma Sequestration Reduce Post-Operative Bleeding?

1989 • 2 citations