Cytokine and complement levels in patients undergoing cardiopulmonary bypass

THE PHENOMENON OF THE ACUTE PHASE RESPONSE*

1982 • 1,498 citations

Complement and the damaging effects of cardiopulmonary bypass

1983 • 1,360 citations

Complement Activation during Cardiopulmonary Bypass

1981 • 1,163 citations

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

1987 • 690 citations

Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes.

1978 • 512 citations

Recombinant human interleukin‐6 (IL‐6/BSF‐2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes

1988 • 458 citations

Induction of rat acute‐phase proteins by interleukin 6 in vivo

1988 • 412 citations

Interleukin-6 as a new indicator of inflammatory status: detection of serum levels of interleukin-6 and C-reactive protein after surgery.

1992 • 336 citations

Complement activation and neutropenia occurring during cardiopulmonary bypass

1981 • 324 citations

IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo.

1989 • 307 citations

Reduced complement activation with heparin-coated oxygenator and tubings in coronary bypass operations

1992 • 255 citations

Effects of Protamine Administration after Cardiopulmonary Bypass on Complement, Blood Elements, and the Hemodynamic State

1986 • 247 citations

Induction of interleukin-1 production in patients undergoing cardiopulmonary bypass

1989 • 247 citations

Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: translational signal provided by lipopolysaccharide or IL-1 itself

1990 • 232 citations

Distinct sets of acute phase plasma proteins are stimulated by separate human hepatocyte-stimulating factors and monokines in rat hepatoma cells.

1987 • 228 citations

Recombinant interleukin 6 regulates the transcriptional activation of a set of human acute phase genes.

1988 • 215 citations

Inhibition by dexamethasone of the reperfusion phenomena in cardiopulmonary bypass

1991 • 210 citations

HEPATOCYTE‐STIMULATING FACTOR: A MONOCYTE‐DERIVED ACUTE‐PHASE REGULATORY PROTEIN

1983 • 207 citations

C5a induction of human interleukin 1. Synergistic effect with endotoxin or interferon-gamma.

1987 • 195 citations

Recombinant C5a enhances interleukin 1 and tumor necrosis factor release by lipopolysaccharide‐stimulated monocytes and macrophages

1990 • 189 citations

Interleukin-6 is the Major Regulator of Acute Phase Protein Synthesis in Rat and Man

1989 • 182 citations

The Effects of Complement Activation During Cardiopulmonary Bypass

1988 • 179 citations

Deposition of Terminal C5b–9 Complement Complexes on Erythrocytes and Leukocytes during Cardiopulmonary Bypass

1988 • 155 citations

Cytokine responses to cardiopulmonary bypass with membrane and bubble oxygenation

1992 • 152 citations

C5a-mediated release of interleukin 6 by human monocytes

1990 • 147 citations

Radioimmunoassay for anaphylatoxins: A sensitive method for determining complement activation products in biological fluids

1984 • 142 citations

Evidence for complement activation by protamine-heparin interaction after cardiopulmonary bypass.

1985 • 136 citations

IL-6 functions as an exocrine hormone in inflammation. Hepatocytes undergoing acute phase responses require exogenous IL-6.

1990 • 127 citations

Interleukin‐6

1989 • 127 citations

IFN beta 2/BSF2/IL-6 is the monocyte-derived HSF that regulates receptor-specific acute phase gene regulation in hepatocytes.

1989 • 101 citations

Complement activation and lung permeability during cardiopulmonary bypass

1990 • 100 citations

IFNβ2/BSF2/IL‐6 Is the Monocyte‐derived HSF That Regulates Receptor‐specific Acute Phase Gene Regulation in Hepatocytes^a

1989 • 94 citations

Complement Activation in Cardiopulmonary Bypass, with Special Reference to Anaphylatoxin Production in Membrane and Bubble Oxygenators

1988 • 64 citations

Limited effects of recombinant human and murine interleukin 1 and tumour necrosis factor on production of acute phase proteins by cultured rat hepatocytes.

1987 • 58 citations

Different oxygenators for cardiopulmonary bypass lead to varying degrees of human complement activation in vitro

1989 • 40 citations

Reduction of complement activation during bypass by prime manipulation

1990 • 38 citations

Absence of complement-mediated events after protamine reversal of heparin anticoagulation

1991 • 4 citations