MIF regulates innate immune responses through modulation of Toll-like receptor 4

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

1999 • 3,364 citations

MECHANISMS OF PHAGOCYTOSIS IN MACROPHAGES

1999 • 2,766 citations

Phylogenetic Perspectives in Innate Immunity

1999 • 2,478 citations

MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

1999 • 2,188 citations

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

2000 • 2,023 citations

Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction

1999 • 1,905 citations

Proinflammatory Cytokines

2000 • 1,857 citations

Structure and Function of Lipopolysaccharide Binding Protein

1990 • 1,689 citations

Mechanism of a Reaction in Vitro Associated with Delayed-Type Hypersensitivity

1966 • 1,604 citations

Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.

1966 • 1,274 citations

MIF as a glucocorticoid-induced modulator of cytokine production

1995 • 1,143 citations

MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia

1993 • 995 citations

The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor.

1994 • 990 citations

Protection from septic shock by neutralization of macrophage migration inhibitory factor

2000 • 728 citations

An essential regulatory role for macrophage migration inhibitory factor in T-cell activation.

1996 • 670 citations

Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1

2000 • 567 citations

Targeted Disruption of Migration Inhibitory Factor Gene Reveals Its Critical Role in Sepsis

1999 • 545 citations

Cutting Edge: Cell Surface Expression and Lipopolysaccharide Signaling Via the Toll-Like Receptor 4-MD-2 Complex on Mouse Peritoneal Macrophages

2000 • 473 citations

Migration inhibitory factor expression in experimentally induced endotoxemia.

1997 • 288 citations

PU.1 and Interferon Consensus Sequence-binding Protein Regulate the Myeloid Expression of the Human Toll-like Receptor 4 Gene

2000 • 244 citations

Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria

1998 • 237 citations

Cutting Edge: Cells That Carry A Null Allele for Toll-Like Receptor 2 Are Capable of Responding to Endotoxin

1999 • 236 citations

Insulin secretion is regulated by the glucose-dependent production of islet β cell macrophage migration inhibitory factor

1997 • 208 citations

Monoclonal Antibodies to Murine Lipopolysaccharide (LPS)-Binding Protein (LBP) Protect Mice from Lethal Endotoxemia by Blocking Either the Binding of LPS to LBP or the Presentation of LPS/LBP Complexes to CD14

1999 • 91 citations

Biologic significance of GATA-1 activities in Ras-mediated megakaryocytic differentiation of hematopoietic cell lines

2000 • 53 citations

Inhibition by a CD14 monoclonal antibody of lipopolysaccharide binding to murine macrophages

1999 • 22 citations