Oxidation and Aging: Impact on Vision

Antioxidant defenses and lipid peroxidation in human blood plasma.

1988 • 1,253 citations

Free radical tissue damage: protective role of antioxidant nutrients ¹

1987 • 1,210 citations

Ageing and degeneration in the macular region: a clinico-pathological study.

1976 • 868 citations

THE FRAMINGHAM EYE STUDY

1977 • 772 citations

Effect of Ultraviolet Radiation on Cataract Formation

1988 • 730 citations

Age-related macular degeneration

1988 • 668 citations

New Concepts in the Biology and Biochemistry of Ascorbic Acid

1986 • 650 citations

SENILE MACULAR DEGENERATION: A CASE-CONTROL STUDY

1983 • 599 citations

The Lens Opacities Case-Control Study

1991 • 594 citations

Pathophysiology of age-related macular degeneration

1987 • 586 citations

Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells.

1984 • 556 citations

Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes.

1986 • 547 citations

The macular pigment. II. Spatial distribution in primate retinas.

1984 • 530 citations

Analysis of the macular pigment by HPLC: retinal distribution and age study.

1988 • 522 citations

Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration.

1989 • 482 citations

Laser Photocoagulation of Subfoveal Neovascular Lesions in Age-Related Macular Degeneration

1991 • 475 citations

Molecular and Cellular Biology of the Eye Lens.

1981 • 447 citations

Antioxidant activity of β‐carotene‐related carotenoids in solution

1989 • 429 citations

Aging changes in Bruch's membrane. A histochemical and morphologic study.

1990 • 404 citations

Argon Laser Photocoagulation for Neovascular Maculopathy

1991 • 402 citations

The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E

1988 • 397 citations

Solar radiation and age-related macular degeneration

1988 • 394 citations

Argon Laser Photocoagulation for Senile Macular Degeneration

1982 • 390 citations

FACTORS ASSOCIATED WITH AGE-RELATED MACULAR DEGENERATION

1988 • 387 citations

The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium.

1978 • 384 citations

Carotenoids in the human macula and whole retina.

1988 • 344 citations

The influence of smoking on vitamin C status in adults.

1989 • 343 citations

India-US Case-Control Study of Age-Related Cataracts

1989 • 319 citations

Oxidative stress on lens and cataract formation: role of light and oxygen

1984 • 305 citations

Interaction of Oxygen and Oxy-radicals With Carotenoids<xref ref-type="fn" rid="FN1">1</xref>

1982 • 300 citations

Aging Changes in Bruch's Membrane

1990 • 294 citations

Retinal Pigment Epithelial Abnormalities in Fundus Flavimmaculatus

1980 • 284 citations

Cataracts and Macular Degeneration in Older Americans

1982 • 278 citations

Exposure to Sunlight and Other Risk Factors for Age-Related Macular Degeneration

1989 • 266 citations

Epidemiologic evidence of a role for the antioxidant vitamins and carotenoids in cataract prevention

1991 • 265 citations

Glutathione and its function in the lens—An overview

1990 • 246 citations

DRUSEN AND THEIR RELATIONSHIP TO SENILE MACULAR DEGENERATION

1980 • 223 citations

THE INTRA-OCULAR COLOUR-FILTERS OF VERTEBRATES

1933 • 214 citations

The protective effect of ascorbate in retinal light damage of rats.

1985 • 212 citations

Age-Related Changes in the Ultrastructure of Bruch's Membrane

1985 • 208 citations

Antioxidant Status in Persons With and Without Senile Cataract

1988 • 204 citations

Protein oxidation and loss of protease activity may lead to cataract formation in the aged lens

1987 • 196 citations

Ultraviolet Light Exposure and Risk of Posterior Subcapsular Cataracts

1989 • 189 citations

Relationship of Senile Macular Degeneration to Ocular Pigmentation

1985 • 179 citations

Antioxidant Enzymes in the Aging Human Retinal Pigment Epithelium

1991 • 177 citations

Retinal degeneration in monkeys induced by deficiencies of vitamin E or A.

1974 • 170 citations

Histopathologic Findings in Best's Vitelliform Macular Dystrophy

1988 • 170 citations

THE EPIDEMIOLOGY OF SENILE CATARACTS: A REVIEW

1983 • 166 citations

Cigarette Smoking and Risk of Nuclear Cataracts

1989 • 166 citations

Nutritional Factors in Cataract

1990 • 162 citations

The role of antioxidants in the retina and retinal pigment epithelium and the nature of prooxidant-induced damage

1986 • 159 citations

Vitamin E Intake and Risk of Cataracts in Humans^a

1989 • 156 citations

Effect of light history on retinal antioxidants and light damage susceptibility in the rat

1987 • 155 citations

ASSOCIATIONS AMONG CATARACT PREVALENCE, SUNLIGHT HOURS, AND ALTITUDE IN THE HIMALAYAS1

1983 • 152 citations

Influence of early photoreceptor degeneration on lipofuscin in the retinal pigment epithelium

1986 • 146 citations

Epidemiology of eye disease in the elderly

1987 • 141 citations

Cataract and Abnormalities of the Lens

1975 • 133 citations

Fluorescent pigment accumulation in retinal pigment epithelium of antioxidant-deficient rats.

1978 • 128 citations

Micronutrients in health and in disease prevention

1991 • 127 citations

Relationship in humans between ascorbic acid consumption and levels of total and reduced ascorbic acid in lens, aqueous humor, and plasma

1991 • 122 citations

Deficiencies of vitamins E and A in the rat. Retinal damage and lipofuscin accumulation.

1980 • 121 citations

CAROTENOID CHROMOPHORE LENGTH AND PROTECTION AGAINST PHOTOSENSITIZATION

1974 • 119 citations

Senile macular degeneration and risk factors: a case-control study.

1979 • 117 citations

The role of ocular pigmentation in protecting against retinal light damage

1980 • 112 citations

Biochemistry of the Eye

1991 • 108 citations

Short-wavelength-sensitive-cone sensitivity loss with aging: a protective role for macular pigment?

1988 • 108 citations

THE RELATIONSHIP OF PLASMA CAROTENOIDS TO HEALTH AND BIOCHEMICAL FACTORS IN MIDDLE-AGED MEN1

1985 • 103 citations

Prevention of selenite cataract by vitamin C

1991 • 103 citations

Central Sparing in Annular Macular Degeneration

1988 • 102 citations

Singlet oxygen as a possible factor in human senile nuclear cataract development

1984 • 94 citations

Cataracts and cigarette smoking: The City Eye Study

1989 • 88 citations

Relationship between Dietary Intake and Tissue Levels of Reduced and Total Vitamin C in the Nonscorbutic Guinea Pig

1989 • 85 citations

Prevention of Sugar-Induced Cataractogenesis in Rats by Butylated Hydroxytoluene

1988 • 85 citations

The Dimensions of the Problem of Eye Disease Among the Elderly

1987 • 79 citations

The role of sunlight in human cataract formation

1983 • 79 citations

Delay of uv-induced eye lens protein damage in guinea pigs by dietary ascorbate

1986 • 79 citations

Nutrition in the elderly : the Boston nutritional status survey

1992 • 79 citations

Modelling cortical cataractogenesis VII: Effects of vitamin E treatment on galactose-induced cataracts

1985 • 78 citations

Development of lipofuscin-like fluorescence in the retinal pigment epithelium in response to protease inhibitor treatment

1989 • 78 citations

Vitamin C status and nutrient interactions in a healthy elderly population.

1988 • 78 citations

PHOTODAMAGE TO THE EYE

1987 • 77 citations

Growth of cultured RPE and endothelial cells is inhibited by blue light but not green or red light

1990 • 72 citations

The autofluorescent products of lipid peroxidation may not be lipofuscin-like

1989 • 68 citations

Exposure of rabbit lens to hyperbaric oxygen in vitro: regional effects on GSH level.

1988 • 68 citations

Retinal light damage reduces autofluorescent pigment deposition in the retinal pigment epithelium.

1989 • 65 citations

Effect of oral glutathione on hepatic glutathione levels in rats and mice

1989 • 65 citations

Aging and cellular maturation cause changes in ubiquitin-eye lens protein conjugates

1990 • 64 citations

The protective effect of ascorbic acid in retinal light damage of rats exposed to intermittent light.

1990 • 63 citations

Ubiquitin and ubiquitin conjugates in human lens

1992 • 62 citations

Associations between Nutrition and Cataract

2009 • 59 citations

Effect of vitamin E on glutathione content in red blood cells, aqueous humor and lens of humans and other species

1986 • 59 citations

There are Different Kinds of Retinal Light Damage in the Rat

1980 • 56 citations

Epidemiology and risk factors for cataract

1987 • 55 citations

Eclipse blindness. Report of an epidemic in the military population of Hawaii.

1966 • 54 citations

The diurnal susceptibility of rat retinal photoreceptors to light-induced damage

1985 • 53 citations

Pathologic Findings of Photic Retinopathy in the Human Eye

1991 • 49 citations

Ceroid-lipofuscinosis (Batten's Disease)

1984 • 49 citations

Measures of leucine aminopeptidase can be used to anticipate UV-induced age-related damage to lens proteins: Ascorbate can delay this damage

1987 • 48 citations

Retinal Phototoxicity from the Operating Microscope

1988 • 48 citations

Eclipse Blindnessast

1966 • 45 citations

The alteration of lipid peroxide in glucocorticoid-induced cataract of developing chick embryos and the effect of ascorbic acid

1986 • 45 citations

Eye Pigmentation and Constant Light Damage in the Rat Retina

1980 • 45 citations

Protection from light damage by ocular pigmentation: Analysis using experimental chimeras and translocation mice

1987 • 42 citations

Bovine lens epithelial cells have a ubiquitin-dependent proteolysis system

1993 • 41 citations

Use of Guinea Pigs as Model to Study Galactose-Induced Cataract Formation

1978 • 39 citations

Reduced and total ascorbate in guinea pig eye tissues in response to dietary intake

1988 • 38 citations

Protease activities in cultured beef lens epithelial cells peak and then decline upon progressive passage

1988 • 34 citations

Evidence for ATP and ubiquitin dependent degradation of proteins in cultured bovine lens epithelial cells

1991 • 27 citations

Glutathione synthesis and glutathione redox pathways in naphthalene cataract of the rat

1990 • 27 citations

Photobiology of Carotenoid Protection

1982 • 22 citations

Über das Vitamin C in der Linse und dem Kammerwasser der menschlichen Katarakte

1935 • 22 citations

The Association of iris Color with Eye Disease in Diabetes

1987 • 21 citations

Vitamin E in human neural retina and retinal pigment epithelium: Effect of age

1987 • 20 citations

Prevalence of age-related cataract in Ganzi and Shanghai. The Epidemiological Study Group.

1990 • 17 citations

Intracellular protein degradation in cultured bovine lens epithelial cells

1988 • 17 citations

BIOCHEMISTRY OF THE LENS

1936 • 17 citations

Aging alterations of retina and choroid of Japanese: light microscopic study of macular region of 176 eyes.

1984 • 17 citations

Aging in the eye lens: Roles for proteolysis and nutrition in formation of cataract

1991 • 13 citations

Age-related Macular Degeneration

1986 • 12 citations

Retinal Damage from Intense Visible Light

1989 • 8 citations

Nutritional Ophthalmology

1981 • 5 citations