Understanding structural relationships proteins of unsolved three‐dimensional structure

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

PROTEIN-DNA RECOGNITION

1984 • 1,649 citations

4 Lactate Dehydrogenase

1975 • 1,272 citations

Potential Metal-Binding Domains in Nucleic Acid Binding Proteins

1986 • 1,096 citations

Simple method for identification of plasmid-coded proteins

1979 • 1,054 citations

Hydrogen bonding and biological specificity analysed by protein engineering

1985 • 1,050 citations

Comparison of super-secondary structures in proteins

1973 • 885 citations

Similar Amino Acid Sequences: Chance or Common Ancestry?

1981 • 855 citations

Zinc fingers: Gilt by association

1988 • 799 citations

AMINOACYL tRNA SYNTHETASES: GENERAL SCHEME OF STRUCTURE-FUNCTION RELATIONSHIPS IN THE POLYPEPTIDES AND RECOGNITION OF TRANSFER RNAS

1987 • 535 citations

Determinants of a protein fold

1987 • 498 citations

Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor

1987 • 434 citations

On the use of sequence homologies to predict protein structure: identical pentapeptides can have completely different conformations.

1984 • 386 citations

Combinatorial Cassette Mutagenesis as a Probe of the Informational Content of Protein Sequences

1988 • 326 citations

A protein required for splicing group I introns in Neurospora mitochondria is mitochondrial tyrosyl-tRNA synthetase or a derivative thereof

1987 • 265 citations

Specific Sequence Homology and Three-Dimensional Structure of an Aminoacyl Transfer RNA Synthetase

1984 • 264 citations

Modification of Methionyl‐tRNA Synthetase by Proteolytic Cleavage and Properties of the Trypsin‐Modified Enzyme

1971 • 223 citations

The NAM2 proteins from S. cerevisiae and S. douglasii are mitochondrial leucyl-tRNA synthetases, and are involved in mRNA splicing.

1988 • 196 citations

Relation between structure and function of α/β–protejns

1980 • 194 citations

Structural plasticity broadens the specificity of an engineered protease

1989 • 165 citations

Biological Macromolecules and Assemblies

1985 • 163 citations

A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor

1986 • 160 citations

Evidence for Dispensable Sequences Inserted into a Nucleotide Fold

1987 • 157 citations

Tyrosyl-tRNA synthetase forms a mononucleotide-binding fold

1982 • 149 citations

Deletion of an essential gene in Escherichia coli by site-specific recombination with linear DNA fragments

1984 • 148 citations

Crystal structure of Escherichia coli methionyl-tRNA synthetase at 2.5 Å resolution

1982 • 136 citations

Crystal structure of a deletion mutant of a tyrosyl-tRNA synthetase complexed with tyrosine

1987 • 117 citations

A model of synthetase/transfer RNA interaction as deduced by protein engineering

1986 • 117 citations

The Amino Acid Sequence of the Tyrosy1-tRNA Synthetase from Bacillus stearothermophilus

1983 • 112 citations

Escherichia coli glutaminyl-tRNA synthetase. II. Characterization of the glnS gene product.

1982 • 97 citations

Molecular cloning and primary structure of the Escherichia coli methionyl-tRNA synthetase gene

1984 • 94 citations

Gene for yeast glutamine tRNA synthetase encodes a large amino-terminal extension and provides a strong confirmation of the signature sequence for a group of the aminoacyl-tRNA synthetases.

1987 • 94 citations

Methionyl-tRNA synthetase from Escherichia coli: primary structure at the binding site for the 3'-end of tRNAfMet

1985 • 85 citations

Glutamyl-tRNA synthetase of Escherichia coli. Isolation and primary structure of the gltX gene and homology with other aminoacyl-tRNA synthetases.

1986 • 84 citations

Deletion mutagenesis using an ‘M13 splint’: the N-terminal structural domain of tyrosyl-tRNA synthetase (B. stearothermophilus) catalyses the formation of tyrosyl adenylate.

1983 • 82 citations

Primary structure of the Saccharomyces cerevisiae gene for methionyl-tRNA synthetase.

1983 • 77 citations

MSW, a yeast gene coding for mitochondrial tryptophanyl-tRNA synthetase.

1985 • 73 citations

The tyrosyl‐tRNA synthetase from Escherichia coli

1982 • 69 citations

The nucleotide sequence of the structural gene for Escherichia coli tryptophanyl-tRNA synthetase.

1982 • 68 citations

Structural homology in the amino-terminal domains of two aminoacyl-tRNA synthetases

1983 • 68 citations

Methionyl-tRNA synthetase shows the nucleotide binding fold observed in dehydrogenases

1981 • 66 citations

Valyl-tRNA synthetase gene of Escherichia coli K12. Primary structure and homology within a family of aminoacyl-TRNA synthetases.

1988 • 64 citations

Dispensable pieces of an aminoacyl tRNA synthetase which activate the catalytic site

1984 • 62 citations

Natural variation of tyrosyl-tRNA synthetase and comparison with engineered mutants

1986 • 60 citations

Active Human-Yeast Chimeric Phosphoglycerate Kinases Engineered by Domain Interchange

1986 • 57 citations

Structure of the yeast valyl-tRNA synthetase gene (VASI) and the homology of its translated amino acid sequence with Escherichia coli isoleucyl-tRNA synthetase.

1987 • 57 citations

The amino acid sequence of tryptophanyl tRNA Synthetase from Bacillus stearothermophilus

1977 • 52 citations

Structure-activity relationships of methionyl-tRNA synthetase: graphics modelling and genetic engineering

1987 • 52 citations

Molecular cloning and micleotide sequence of the gene forEscherichia colileucyl-tRNA synthetase

1987 • 51 citations

Isolation and characterization of the gene coding for Escherichia coli arginyl-tRNA synthetase

1989 • 46 citations

Internal structural features of E. coli glycyl-tRNA synthetase examined by subunit polypeptide chain fusions.

1986 • 45 citations

Prediction of a common structural domain in aminoacyl-tRNA synthetases through use of a new pattern-directed inference system

1987 • 43 citations

Characterization of MSM1, the structural gene for yeast mitochondrial methionyl‐tRNA synthetase

1989 • 38 citations

Evidence from Cassette Mutagenesis for a Structure-Function Motif in a Protein of Unknown Structure

1988 • 38 citations

Insertion of new sequences into the catalytic domain of an enzyme

1989 • 38 citations

Structure of the Yeast Isoleucyl-tRNA Synthetase Gene (ILS1). DNA-Sequence, Amino-Acid Sequence of Proteolytic Peptides of the Enzyme and Comparison of the Structure to those of other Known Aminoacyl-tRNA Synthetases

1987 • 36 citations

The valyl-tRNA synthetase from Bacillus stearothermophilus has considerable sequence homology with the isoleucyl-tRNA synthetase from Escherichia coli

1987 • 36 citations

Aminoacyl-tRNA synthetase families and their significance to the origin of the genetic code

1978 • 35 citations

A modified Chou and Fasman protein structure algorithm

1987 • 33 citations

Identification of peptide sequences at the tRNA binding site of Escherichia coli methionyl-tRNA synthetase

1986 • 32 citations

Reconstruction of an enzyme by domain substitution effectively switches substrate specificity

1989 • 31 citations

THE CRYSTAL STRUCTURE OF LACTIC DEHYDROGENASE

1967 • 29 citations

The core region of human glutaminyl-tRNA synthetase homologies with theEscherichia cotiand yeast enzymes

1988 • 25 citations

Cytoplasmic leucyl-tRNA synthetase of Neurospora crassa is not specified by the leu-5 locus.

1988 • 14 citations

Modification of l-Isoleucyl-tRNA Synthetase with l-Isoleucyl-Bromomethyl Ketone. The Effect on the Catalytic Steps

1977 • 13 citations

Peptides at the tRNA binding site of the crystallizable monomeric form ofE.colimethionyl-tRNA synthetase

1987 • 7 citations

Construction of Intra-Domain Chimeras of Aminoacyl-tRNA Synthetases

1989 • 5 citations