Insertion of new sequences into the catalytic domain of an enzyme

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

THE INHIBITION OF CHOLINESTERASE BY PHYSOSTIGMINE AND PROSTIGMINE

1942 • 616 citations

AMINOACYL tRNA SYNTHETASES: GENERAL SCHEME OF STRUCTURE-FUNCTION RELATIONSHIPS IN THE POLYPEPTIDES AND RECOGNITION OF TRANSFER RNAS

1987 • 535 citations

Loops in Globular Proteins: A Novel Category of Secondary Structure

1986 • 533 citations

Non-Inverted Versus Inverted Plots in Enzyme Kinetics

1959 • 463 citations

High mutation frequency in DNA transfected into mammalian cells.

1983 • 338 citations

Combinatorial Cassette Mutagenesis as a Probe of the Informational Content of Protein Sequences

1988 • 326 citations

Active site titration and aminoacyl adenylate binding stoichiometry of aminoacyl-tRNA synthetases

1975 • 226 citations

Modification of Methionyl‐tRNA Synthetase by Proteolytic Cleavage and Properties of the Trypsin‐Modified Enzyme

1971 • 223 citations

Structural plasticity broadens the specificity of an engineered protease

1989 • 165 citations

Evidence for Dispensable Sequences Inserted into a Nucleotide Fold

1987 • 157 citations

Single-stranded hexameric linkers: a system for in-phase insertion mutagenesis and protein engineering

1985 • 151 citations

Tyrosyl-tRNA synthetase forms a mononucleotide-binding fold

1982 • 149 citations

Crystal structure of Escherichia coli methionyl-tRNA synthetase at 2.5 Å resolution

1982 • 136 citations

Two-codon insertion mutagenesis of plasmid genes by using single-stranded hexameric oligonucleotides.

1985 • 126 citations

Identification of functional regions in the transforming protein of Fujinami sarcoma virus by in-phase insertion mutagenesis

1984 • 113 citations

Molecular cloning and primary structure of the Escherichia coli methionyl-tRNA synthetase gene

1984 • 94 citations

Methionyl-tRNA synthetase from Escherichia coli. Primary structure of the active crystallised tryptic fragment.

1982 • 89 citations

A covalent adduct between the uracil ring and the active site of an aminoacyl tRNA synthetase

1982 • 82 citations

One and two codon insertion mutants of bacteriophage f1

1981 • 80 citations

Primary structure of the Saccharomyces cerevisiae gene for methionyl-tRNA synthetase.

1983 • 77 citations

Structural homology in the amino-terminal domains of two aminoacyl-tRNA synthetases

1983 • 68 citations

Methionyl-tRNA synthetase shows the nucleotide binding fold observed in dehydrogenases

1981 • 66 citations

Structure-activity relationships of methionyl-tRNA synthetase: graphics modelling and genetic engineering

1987 • 52 citations

Internal structural features of E. coli glycyl-tRNA synthetase examined by subunit polypeptide chain fusions.

1986 • 45 citations

A genetic system for isolation and characterization of TaqI restriction endonuclease mutants

1987 • 42 citations

Codon insertion mutants of the adenovirus terminal protein.

1986 • 41 citations

Glycogen phosphorylase b — the molecular anatomy of a large regulatory enzyme

1985 • 7 citations