Molecular Genetics of Na,K-ATPase

A catalogue of splice junction sequences

1982 • 3,861 citations

Why genes in pieces?

1978 • 2,256 citations

Nerve, Muscle and Synapse

1966 • 1,431 citations

Amino-acid sequence of a Ca2+ + Mg2+ -dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence

1985 • 1,126 citations

The Sodium Pump

1975 • 969 citations

Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

1988 • 877 citations

The sodium-potassium adenosine triphosphatase: pharmacological, physiological and biochemical aspects.

1975 • 868 citations

Electrogenic sodium pump in nerve and muscle cells.

1972 • 787 citations

Amino-acid sequence of the catalytic subunit of the (Na+ + K+)ATPase deduced from a complementary DNA

1985 • 762 citations

Burger's Medicinal chemistry

1980 • 709 citations

Kinetic Properties of the Plasma Membrane Na+ -H+ Exchanger

1985 • 670 citations

Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated.

1984 • 609 citations

Regulation of cellular volume.

1977 • 607 citations

Two molecular forms of (Na+ + K+)-stimulated ATPase in brain. Separation, and difference in affinity for strophanthidin.

1979 • 598 citations

The Kidney: Physiology and Pathophysiology

1985 • 508 citations

Mechanism of the Na+, K+ pump protein structure and conformations of the pure

1982 • 500 citations

Molecular cloning of the rat stomach (H+ + K+)-ATPase.

1986 • 463 citations

Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals.

1987 • 445 citations

Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts

1983 • 445 citations

Tissue-specific and developmental regulation of rat Na,K-ATPase catalytic alpha isoform and beta subunit mRNAs.

1988 • 443 citations

Transformation of rat cells by an altered polyoma virus genome expressing only the middle-T protein

1981 • 435 citations

The effect of catecholamines on Na—K transport and membrane potential in rat soleus muscle

1977 • 403 citations

Correlation of DNA exonic regions with protein structural units in haemoglobin

1981 • 394 citations

Molecular cloning of two isoforms of the plasma membrane Ca2+-transporting ATPase from rat brain. Structural and functional domains exhibit similarity to Na+,K+- and other cation transport ATPases.

1988 • 379 citations

Primary structure of the α-subunit of Torpedo californica (Na+ + K+)ATPase deduced from cDNA sequence

1985 • 375 citations

Heterogeneity and 5′-terminal structures of the late RNAs of simian virus 40

1978 • 372 citations

Genes-in-Pieces Revisited

1985 • 362 citations

Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments

1979 • 329 citations

A minimal intron length but no specific internal sequence is required for splicing the large rabbit β-globin intron

1984 • 328 citations

Ouabain-sensitive (Na+ + K+)-ATPase activity expressed in mouse L cells by transfection with DNA encoding the alpha-subunit of an avian sodium pump.

1988 • 320 citations

Serum stimulates the Na+,K+ pump in quiescent fibroblasts by increasing Na+ entry.

1978 • 319 citations

Mutation of aspartic acid-351, lysine-352, and lysine-515 alters the Ca2+ transport activity of the Ca2+-ATPase expressed in COS-1 cells.

1988 • 298 citations

Do genes-in-pieces imply proteins-in-pieces?

1978 • 287 citations

Alpha-skeletal muscle actin mRNA's accumulate in hypertrophied adult rat hearts.

1986 • 282 citations

Effects of insulin upon ion transport

1983 • 277 citations

Transepithelial transport by pulmonary alveolar type II cells in primary culture.

1982 • 269 citations

Splice Junctions: Association with Variation in Protein Structure

1983 • 261 citations

Amino-acid sequence of the β-subunit of the (Na+ + K+)ATPase deduced from a cDNA

1986 • 245 citations

Differential liquid and protein clearance from the alveoli of anesthetized sheep

1982 • 245 citations

Ion motive ATPases. II. Energy coupling and work output

1987 • 237 citations

Glial cell function: Active control of extracellular K+ concentration

1972 • 233 citations

Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications.

1987 • 231 citations

Mechanisms of ion transport across the choroid plexus

1972 • 230 citations

The amino acid sequence of a fluorescein-labeled peptide from the active site of (Na,K)-ATPase.

1984 • 212 citations

Development of acetylcholine sensitivity during myogenesis

1971 • 211 citations

Molecular considerations relevant to the mechanism of active transport

1981 • 210 citations

Pig kidney Na⁺,K⁺‐ATPase

1986 • 207 citations

Hormonal control of kidney functions at the cell level.

1986 • 206 citations

Secondary effect of aldosterone on Na-KATPase activity in the rabbit cortical collecting tubule.

1981 • 205 citations

BKV splice sequences based on analysis of preferred donor and acceptor sites

1979 • 198 citations

Control of protein synthesis in human fibroblasts by intracellular potassium*1

1977 • 194 citations

Sugar, Amino Acid, and NA+ Cotransport in the Proximal Tubule

1979 • 191 citations

Über die ursache der speciesunterschiede in der digitalisempfindlichkeit

1965 • 188 citations

Sodium-Calcium Exchange in Plasma Membrane Vesicles

1985 • 186 citations

Sodium-Calcium Exchange in the Heart

1982 • 186 citations

Effect of triiodothyronine on the synthesis and degradation of renal cortical (Na+ + k+)-adenosine triphosphatase

1976 • 184 citations

The Na,K-ATPase of nervous tissue

1986 • 174 citations

The (Na+ + K+)-ATPase of chick sensory neurons. Studies on biosynthesis and intracellular transport.

1986 • 169 citations

Insulin affects the sodium affinity of the rat adipocyte (Na+,K+)-ATPase.

1985 • 164 citations

Photoaffinity Labeling of the Ouabain-Binding Site on (Na ⁺ + K ⁺ ) Adenosinetriphosphatase

1974 • 160 citations

Dependence of renal (Na+ + k+)-adenosine triphosphatase activity on thyroid status

1976 • 160 citations

Increased (Na+,K+)-ATPase concentrations in various tissues of rats caused by thyroid hormone treatment.

1978 • 158 citations

Hormonal regulation of (Na+,K+)-ATPase biosynthesis in the toad bladder. Effect of aldosterone and 3,5,3'-triiodo-L-thyronine.

1982 • 158 citations

Molecular cloning and sequence analysis of human Na, K-ATPase β–subunit

1986 • 156 citations

Regulation by aldosterone of Na+,K+-ATPase mRNAs, protein synthesis, and sodium transport in cultured kidney cells.

1987 • 154 citations

Insulin stimulation of (Na+,K+)-adenosine triphosphatase-dependent 86Rb+ uptake in rat adipocytes.

1980 • 153 citations

Insulin and glucagon stimulation of (Na+-K+)-ATPase transport activity in isolated rat hepatocytes.

1981 • 150 citations

Two isozymes of the Na,K-ATPase have distinct antigenic determinants.

1985 • 150 citations

Intron–exon splice junctions map at protein surfaces

1982 • 148 citations

Isoform-Specific Modulation of Na ⁺ , K ⁺ -ATPase α-Subunit Gene Expression in Hypertension

1988 • 146 citations

Intron/exon structure of the chicken pyruvate kinase gene

1985 • 144 citations

Lung fluid balance in lambs before and after birth

1982 • 143 citations

High-affinity ouabain binding site and low-dose positive inotropic effect in rat myocardium

1982 • 143 citations

Regulation of the (Na+ + K+)-ATPase in cultured chick skeletal muscle. Modulation of expression by the demand for ion transport.

1986 • 140 citations

Rat-brain Na,K-ATPase beta-chain gene: primary structure, tissue-specific expression, and amplification in ouabain-resistant HeLa C+ cells.

1986 • 139 citations

Primary Structure of the α-Subunit of Human Na, K-ATPase Deduced from cDNA Sequence1

1986 • 136 citations

Multiple genes encode the human Na+,K+-ATPase catalytic subunit.

1987 • 135 citations

Structure of the rabbit fast-twitch skeletal muscle Ca2+-ATPase gene.

1988 • 134 citations

The active site structure of Na+/K+-transporting ATPase: location of the 5'-(p-fluorosulfonyl)benzoyladenosine binding site and soluble peptides released by trypsin.

1986 • 129 citations

Multiple mRNAs from rat kidney and brain encode a single Na+,K+-ATPase beta subunit protein.

1987 • 126 citations

Stoichiometry and molecular weight of the minimum asymmetric unit of canine renal sodium and potassium ion-activated adenosine triphosphatase.

1980 • 125 citations

Primary structure of the β‐subunit of Torpedo californica (Na⁺ + K⁺)‐ATPase deduced from the cDNA sequence

1986 • 125 citations

The mechanism of insulin stimulation of (Na+,K+)-ATPase transport activity in muscle.

1985 • 123 citations

Tryptic and chymotryptic cleavage sites in sequence of α-subunit of (Na+ + K+)-ATPase from outer medulla of mammalian kidney

1986 • 121 citations

Effect of Adrenal Steroids on a Na+- and K+-requiring Adenosine Triphosphatase from Rat Kidney

1966 • 120 citations

Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis)

1986 • 120 citations

Na entry and Na‐K pump activity in murine, hamster, and human cells ‐ effect of monensin, serum, platelet extract, and viral transformation

1980 • 119 citations

Correlation of the glycoside response, the force staircase, and the action potential configuration in the neonatal rat heart.

1975 • 116 citations

Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse.

1987 • 115 citations

Relationship between the total size of exons and introns in protein-coding genes of higher eukaryotes.

1982 • 114 citations

STUDIES ON SODIUM–POTASSIUM ADENOSINE TRIPHOSPHATASE OF THE NERVE ENDINGS AND APPEARANCE OF ELECTRICAL ACTIVITY IN DEVELOPING RAT BRAIN

1967 • 113 citations

Tissue specificity, localization in brain, and cell-free translation of mRNA encoding the A3 isoform of Na+,K+-ATPase.

1988 • 113 citations

Evidence for the genetic control of the sodium pump density in HeLa cells

1974 • 111 citations

A comparison of the ATPase activity of the glial cell fraction and the neuronal perikaryal fraction isolated in bulk from rat cerebral cortex¹

1971 • 107 citations

A heterogeneous ouabain-ATPase interaction in mouse brain

1978 • 105 citations

Effect of K+ ions on kinetic properties of the (Na+, K+)-ATPase (EC 3.6.1.3) of bulk isolated glial cells, perikarya and synaptosomes from rabbit brain cortex

1979 • 104 citations

The hormone-sensitive hepatic Na+-pump. Evidence for regulation by diacylglycerol and tumor promoters.

1986 • 102 citations

Rates of dissociation of enzyme-ouabain complexes and K0.5 values in (Na+ + K+) adenosine triphosphatase from different species

1972 • 99 citations

Ouabain binding sites and (Na+,K+)-ATPase activity in rat cardiac hypertrophy. Expression of the neonatal forms.

1986 • 96 citations

Specific inactivation of alpha (+) molecular form of (Na+ + K+)-ATPase by pyrithiamin.

1984 • 94 citations

Expression of hybrid (Na+ + K+)-ATPase molecules after transfection of mouse Ltk-cells with DNA encoding the beta-subunit of an avian brain sodium pump.

1987 • 93 citations

STRUCTURE OF THE Na, K PUMP: CRYSTALLIZATION OF PURE MEMBRANE‐BOUND Na, K‐ATPase AND IDENTIFICATION OF FUNCTIONAL DOMAINS OF THE α‐SUBUNIT

1982 • 89 citations

Evidence for the organization of the transmembrane segments of (Na,K)-ATPase based on labeling lipid-embedded and surface domains of the alpha-subunit.

1982 • 88 citations

Ouabain receptor interactions in (Na+ + K+)-ATPase preparations. II. Effect of cations and nucleotides on rate constants and dissociation constants

1973 • 85 citations

Ouabain Resistance Conferred by Expression of the cDNA for a Murine Na ⁺ , K ⁺ -ATPase α Subunit

1987 • 85 citations

ATPase and carbonic anhydrase activities of bulk-isolated neuron, glia and synaptosome fractions from rat brain

1978 • 84 citations

Effect of Thyroid Hormone on the Abundance of Na, K-Adenosine Triphosphatase α-Subunit Messenger Ribonucleic Acid*

1987 • 83 citations

Exons and the Evolution of Proteins

1985 • 83 citations

Developmental and thyroid hormone regulation of two molecular forms of Na+-K+-ATPase in brain.

1986 • 81 citations

Membrane insertion of alpha- and beta-subunits of Na+,K+-ATPase.

1985 • 81 citations

Ca2+-free perfusion of rat heart reveals a (Na+ + K+) ATPase form highly sensitive to ouabain

1982 • 80 citations

ACTIVE POTASSIUM TRANSPORT AND [Na⁺+ K⁺]ATPase ACTIVITY IN CULTURED GLIOMA AND NEUROBLASTOMA CELLS

1974 • 78 citations

Short-term effect of aldosterone on renal sodium transport and tubular Na?K-ATPase in the rat

1983 • 77 citations

Na⁺, K⁺‐ATPase in HeLa cells after prolonged growth in low K⁺ or ouabain

1981 • 77 citations

Site of Action of Aldosterone on the Bladder of the Toad

1963 • 77 citations

Two different Na,K-ATPases in the optic nerve: cells of origin and axonal transport.

1984 • 77 citations

Affinity modification of E₁‐form of Na⁺, K⁺ ‐ATPase revealed Asp‐710 in the catalytic site

1987 • 77 citations

Thyroid-induced alterations in myocardial sodium-potassium-activated adenosine triphosphatase, monovalent cation active transport, and cardiac glycoside binding.

1977 • 77 citations

The family of human Na⁺,K⁺‐ATPase genes No less than five genes and/or pseudogenes related to the α‐subunit

1987 • 76 citations

Chromosomal localization of human Na+,K+-ATPase α- and β-subunit genes

1988 • 76 citations

Molecular cloning of rat brain Na,K-ATPase alpha-subunit cDNA.

1985 • 75 citations

Sodium-independent in vitro induction of Na+,K+-ATPase by aldosterone in renal target cells: permissive effect of triiodothyronine.

1988 • 72 citations

A Cellular Model for Active Sodium Absorption by Mammalian Colon

1984 • 72 citations

Non-uniform populations of g-strophanthin binding sites of (Na+ + K+)-activated ATPase Apparent conversion to uniformity by K+

1976 • 71 citations

Studies on sodium-potassium-activated adenosine triphosphatase

1962 • 71 citations

Family of human Na⁺,K⁺‐ATPase genes Structure of the gene for the catalytic subunit (αIII‐form) and its relationship with structural features of the protein

1988 • 70 citations

Cation transport in lung epithelial cells derived from fetal, newborn, and adult rabbits

1986 • 70 citations

Vasopressin rapidly stimulates NA entry and NA‐K pump activity in quiescent cultures of mouse 3T3 cells

1980 • 69 citations

Differential expression of the Na,K-ATPase alpha 1 and alpha 2 subunit genes in a murine myogenic cell line. Induction of the alpha 2 isozyme during myocyte differentiation.

1988 • 66 citations

(Na+ + K+)-ATPase: On the number of the ATP sites of the functional unit

1987 • 64 citations

Effect of triiodothyronine on the synthesis and degradation of the small subunit of renal cortical (Na+ + K+)-adenosine triphosphatase.

1980 • 64 citations

Primary Structures of Two Types of Alpha-Subunit of Rat Brain Na+, K+-ATPase Deduced from cDNA Sequences1

1987 • 63 citations

Regulation of Na⁺, K⁺‐ATPase activity in MDCK kidney epithelial cell cultures: Role of growth state, cyclic AMP, and chemical inducers of dome formation and differentiation

1984 • 63 citations

Rat cardiac ventricle has two Na+,K+-ATPases with different affinities for ouabain: developmental changes in immunologically different catalytic subunits.

1987 • 62 citations

The role of aldosterone in the regulation of (Na+ + K+)-ATPase in rat kidney

1972 • 62 citations

Stimulation of Na,K-activated adenosine triphosphatase and active transport by low external K+ in a rat liver cell line.

1986 • 61 citations

Molecular cloning and sequence analysis of the (Na+ + K+)-ATPase β subunit from dog kidney

1987 • 59 citations

Effects of growth in low potassium medium or ouabain on membrane Na,K-ATPase, cation transport, and contractility in cultured chick heart cells.

1984 • 59 citations

Correlation between fluid reabsorption and proximal tubule ultrastructure during development of the rat kidney

1979 • 58 citations

Affinity labeling of the digitalis receptor with p-nitrophenyltriazene-ouabain, a highly specific alkylating agent.

1980 • 58 citations

Modulation of renal sodium-potassium-adenosine triphosphatase by aldosterone. Effect of high physiologic levels on enzyme activity in isolated rat and rabbit tubules.

1985 • 58 citations

Ouabain-binding-site photoaffinity probes that label both subunits of Na+,K+-ATPase.

1980 • 57 citations

MECHANISM OF ACTION OF ALDOSTERONE WITH PARTICULAR REFERENCE TO (N<scp>a</scp>+ K)‐ATP<scp>ase</scp>*

1974 • 53 citations

DEVELOPMENT OF (Na⁺‐K⁺)‐ATPase IN RAT CEREBRUM: CORRELATION WITH Na ⁺ ‐DEPENDENT PHOSPHORYLATION AND K ⁺‐para NITROPHENYLPHOSPHATASE¹

1978 • 50 citations

Expression of an ouabain-resistant Na,K-ATPase in CV-1 cells after transfection with a cDNA encoding the rat Na,K-ATPase alpha 1 subunit.

1988 • 49 citations

Rapid hyperpolarization of rat skeletal muscle induced by insulin

1981 • 49 citations

ELECTROCHEMICAL CHANGES ASSOCIATED WITH THE FORMATION OF THE AQUEOUS HUMOUR

1961 • 47 citations

Origin of differences of inhibitory potency of cardiac glycosides in Na+/K+-transporting ATPase from human cardiac muscle, human brain cortex and guinea-pig cardiac muscle

1986 • 47 citations

DYNAMICS OF PULMONARY WATER BEFORE AND AFTER BIRTH

1983 • 44 citations

Short term effect of low doses of tri-iodothyronine on proximal tubular membrane Na−K-ATPase and potassium permeability in thyroidectomized rats

1985 • 44 citations

Identification of two isoforms of the catalytic subunit of Na,K-ATPase in myocytes from adult rat heart.

1987 • 43 citations

Effects of adrenal steroids on Na transport in the lower intestine (Coprodeum) of the hen

1987 • 42 citations

Early Enhancement of Passive Potassium Efflux from Rat Liver by Thyroid Hormone: Relation to Induction of Na,K-ATPase*

1984 • 42 citations

Stimulation of Rb+ transport by glucagon in isolated rat hepatocytes.

1981 • 41 citations

Relationship between Na+-dependent respiration and Na+ + K+-adenosine triphosphatase activity in the action of thyroid hormone on rat jejunal mucosa

1979 • 39 citations

Steroids, intracellular sodium levels, and Na+/K+-ATPase regulation.

1985 • 39 citations

Two apparently different ouabain binding sites of (Na+−K+)-ATPase

1972 • 39 citations

Characterization of receptor-mediated catecholamine activation of rat brain corticl Na+-K+-ATPase

1980 • 38 citations

Cardiac glycoside receptors in cultured heart cells—II

1984 • 37 citations

Functional activity of oligosaccharide‐deficient (Na,K)ATPase expressed in Xenopus oocytes

1988 • 37 citations

Ontogeny of the (Na+,K+)-ATPase during chick skeletal myogenesis.

1982 • 35 citations

Age-dependent changes in the number of [3H]ouabain-binding sites in rat soleus muscle

1982 • 34 citations

Potassium effect on Na+, K+-ATPase activity of cultured newborn rat astroblasts during differentiation

1977 • 34 citations

Variation in sensitivity of the cardiac glycoside receptor characteristics of (Na+ + K+)-ATPase to lipolysis and temperature

1977 • 33 citations

The (Na,K)-ATPase of Friend erythroleukemia cells is phosphorylated near the ATP hydrolysis by an endogenous membrane-bound kinase.

1984 • 32 citations

Identification of N-[p-(2-benzimidazolyl)phenyl]maleimide-modified residue participating in dynamic fluorescence changes accompanying Na+,K+-dependent ATP hydrolysis.

1986 • 32 citations

The Transmembrane Segment of the Human Na, K-ATPase β-Subunit Acts as the Membrane Incorporation Signal1

1988 • 31 citations

Glial control of neuronal excitability in mammals: II. Enzymatic evidence : Two molecular forms of the (Na+,K+)-ATPase in brain

1980 • 31 citations

Biochemical basis for the low sensitivity of the rat heart to digitalis

1979 • 30 citations

Kinetic analysis of Na,K-activated adenosine triphosphatase induced by low external K+ in a rat liver cell line.

1988 • 29 citations

Na+,K+-ATPase: structure, function, and interactions with drugs.

1986 • 29 citations

Amplification of DNA sequences coding for the Na,K-ATPase alpha-subunit in ouabain-resistant C+ cells.

1986 • 29 citations

Electron microscopic visualization of the arrangement of the two protein components of (Na+ + K+)-ATPase

1977 • 29 citations

Labeling of intramembrane segments of the α-subunit and β-subunit of pure membrane-bound (Na+ + K+)-ATPase with 3-trifluoromethyl-3-(m-[125I]iodophenyl)diazirine

1983 • 27 citations

Serum stimulates na entry and the Na‐K pump in quiescent cultures of epithelial cells (MDCK)

1983 • 26 citations

High affinity and low affinity ouabain binding sites in the rat heart

1986 • 25 citations

Chromosome-mediated transfer of the murine Na,K-ATPase alpha subunit confers ouabain resistance.

1987 • 25 citations

Human placental Na+,K+-ATPase alpha subunit: cDNA cloning, tissue expression, DNA polymorphism, and chromosomal localization.

1987 • 23 citations

Structure of the extra‐membranous domain of the β‐subunit of (Na,K)‐ATPase revealed by the sequences of its tryptic peptides

1986 • 22 citations

Identification of the 5-Iodoacetamidofluorescein Reporter Site on the Na,K-ATPase

1989 • 22 citations

Development of sodium channels during differentiation of chick skeletal muscle in culture. II. 22Na+ uptake and electrophysiological studies

1983 • 21 citations

Interactions of cardiac glycosides with cardiac cells. III. Alterations in the sensitivity of (Na+ + K+)-ATPase to inhibition by ouabain in rat hearts

1982 • 21 citations

Stable gene amplification and overexpression of sodium- and potassium-activated ATPase in HeLa cells.

1986 • 20 citations

Nerve Growth Factor Induces Na⁺, K⁺‐ATPase in a Nerve Cell Line

1988 • 20 citations

Immunochemical comparison of cardiac glycoside-sensitive (lamb) and -insensitive (rat) kidney (Na+ + K+)-ATPase

1986 • 18 citations

Chapter 7 Biosynthesis of Na+, K+-ATPase in Amphibian Epithelial Cells

1984 • 18 citations

Tryptic digest of the α subunit of lamb kidney (Na+ + K+)-ATPase

1983 • 17 citations

Relationships between exons and the predicted structure of membrane-bound proteins

1985 • 14 citations

Studies on the ontogenesis of the different isoenzymes of Na+, K+-ATPase in rat brain in vivo and in vitro in relation to their regulation and cellular localisation

1987 • 13 citations

Detection and localization of a cytoplasmic domain on the beta-subunit of Na+,K+-ATPase. A monoclonal antibody study.

1987 • 8 citations