Intracellular sorting and processing of a yeast vacuolar hydrolase: proteinase A propeptide contains vacuolar targeting information.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Experiments in molecular genetics

1972 • 28,260 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

[12] One-step gene disruption in yeast

1983 • 3,302 citations

A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments

1982 • 3,041 citations

Analysis of gene control signals by DNA fusion and cloning in Escherichia coli

1980 • 2,499 citations

Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway

1980 • 1,808 citations

The trans Golgi Network: Sorting at the Exit Site of the Golgi Complex

1986 • 1,175 citations

Pathways of Protein Secretion in Eukaryotes

1985 • 1,050 citations

Methods in yeast genetics, laboratory manual

1987 • 733 citations

The Molecular Biology of the Yeast Saccharomyces (Metabolism and Gene Expression)

1985 • 712 citations

Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole

1982 • 579 citations

The rate of bulk flow from the endoplasmic reticulum to the cell surface

1987 • 542 citations

A Critical Evaluation of the Nitrogen Assimilation Tests Commonly Used in the Classification of Yeasts

1946 • 530 citations

Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae

1979 • 518 citations

[76] β-d-Fructofuranoside fructohydrolase from yeast

1975 • 455 citations

Protein sorting in yeast: Mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway

1986 • 429 citations

A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum.

1987 • 418 citations

PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors.

1986 • 400 citations

Isolation of yeast mutants defective in protein targeting to the vacuole.

1986 • 394 citations

The Phosphomannosyl Recognition System for Intracellular and Intercellular Transport of Lysosomal Enzymes

1982 • 379 citations

Nuclear location signals in polyoma virus large-T

1986 • 351 citations

Protein sorting in yeast: The localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide

1987 • 329 citations

Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protease

1987 • 312 citations

Molecular structure of an aspartic proteinase zymogen, porcine pepsinogen, at 1.8 Å resolution

1986 • 295 citations

The PEP4 Gene Encodes an Aspartyl Protease Implicated in the Posttranslational Regulation of Saccharomyces cerevisiae Vacuolar Hydrolases

1986 • 292 citations

Tunicamycin — An inhibitor of yeast glycoprotein synthesis

1974 • 289 citations

Endocytosis in yeast: Several of the yeast secretory mutants are defective in endocytosis

1985 • 280 citations

Multiple methods of visualizing the yeast vacuole permit evaluation of its morphology and inheritance during the cell cycle.

1987 • 224 citations

Gene dosage-dependent secretion of yeast vacuolar carboxypeptidase Y.

1986 • 217 citations

Vacuoles: The sole compartments of digestive enzymes in yeast (Saccharomyces cerevisiae)?

1979 • 202 citations

The purification and properties of an α-glucoside of Saccharomyces italicus Y1225

1958 • 202 citations

Mutant defective in processing of an enzyme located in the lysosome-like vacuole of Saccharomyces cerevisiae.

1981 • 199 citations

An MF alpha 1-SUC2 (alpha-factor-invertase) gene fusion for study of protein localization and gene expression in yeast.

1983 • 187 citations

Molecular consequences of specific intron mutations on yeast mRNA splicing in vivo and in vitro

1985 • 172 citations

Biosynthesis of the Vacuolar Yeast Glycoprotein Carboxypeptidase Y

1978 • 164 citations

Overproduction-induced mislocalization of a yeast vacuolar protein allows isolation of its structural gene.

1986 • 151 citations

Carbohydrate Moiety of Carboxypeptidase Y and Perturbation of Its Biosynthesis

1978 • 148 citations

[6] Preparation of Fab fragments from IgGs of different animal species

1980 • 146 citations

GlycoProtein biosynthesis in yeast. protein conformation affects processing of high mannose oligosaccharides on carboxypeptidase Y and invertase.

1983 • 142 citations

The subnuclear localization of tRNA ligase in yeast.

1987 • 133 citations

Activities and cellular localization of yeast proteases and their inhibitors

1974 • 132 citations

Homeo Domain of the Yeast Repressor α2 Is a Sequence-Specific DNA-Binding Domain But Is Not Sufficient for Repression

1987 • 121 citations

Yeast Cell Wall and Cell Surface

1982 • 100 citations

α-d-mannosidase of Saccharomyces cerevisiae Characterization and modulation of activity

1978 • 96 citations

Glycoprotein nature of yeast alkaline phosphatase. Formation of active enzyme in the presence of tunicamycin.

1979 • 96 citations

Studies on the Microsomal Electron-transport System of Anaerobically Grown Yeast

1974 • 93 citations

Studies on the Microsomal Electron-transport System of Anaerobically Grown Yeast

1977 • 92 citations

In vivo biosynthesis of the vacuolar proteinases A and B in the yeast Saccharomyces cerevisiae.

1982 • 92 citations

Protease B of Saccharomyces cerevisiae: Isolation and Regulation of the PRB1 Structural Gene

1987 • 90 citations

The use of endo-β-N-acetylglucosaminidase H in characterizing the structure and function of glycoproteins

1977 • 89 citations

Carbohydrate-free carboxypeptidase Y is transferred into the lysosome-like yeast vacuole

1982 • 89 citations

Maturation of vacuolar (lysosomal) enzymes in yeast: proteinase yscA and proteinase yscB are catalysts of the processing and activation event of carboxypeptidase yscY.

1987 • 85 citations

Secretion-Defective Mutations in the Signal Sequence for Saccharomyces cerevisiae Invertase

1986 • 85 citations

Mutations in PEP4 locus of Saccharomyces cerevisiae block final step in maturation of two vacuolar hydrolases.

1983 • 84 citations

Yeast carboxypeptidase Y can be translocated and glycosylated without its amino-terminal signal sequence.

1987 • 80 citations

Apparent endocytosis of fluorescein isothiocyanate-conjugated dextran by Saccharomyces cerevisiae reflects uptake of low molecular weight impurities, not dextran.

1987 • 79 citations

Some observations on the form and location of invertase in the yeast cell

1961 • 69 citations

The yeast F1-ATPase beta subunit precursor contains functionally redundant mitochondrial protein import information.

1987 • 69 citations

Interorganelle transfer and glycosylation of yeast invertase in vitro.

1986 • 52 citations

Transcriptional and post-transcriptional control of PHO8 expression by PHO regulatory genes in Saccharomyces cerevisiae.

1985 • 47 citations

Invivo biosynthesis of vacuolar proteinases in proteinase mutants of Saccharomycescerevisiae

1982 • 42 citations

Asparagine-linked carbohydrate does not determine the cellular location of yeast vacuolar nonspecific alkaline phosphatase

1982 • 40 citations

Mutations affecting the signal sequence alter synthesis and secretion of yeast invertase.

1986 • 30 citations

Biosynthesis of carboxypeptidase Y in yeast. Evidence for a precursor form of the glycoprotein

1976 • 26 citations