Analgesic Effect of Antidepressant Drugs

Behavioral despair in mice: a primary screening test for antidepressants.

1977 • 3,241 citations

Behavioural despair in rats: A new model sensitive to antidepressant treatments

1978 • 3,035 citations

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry

1984 • 2,580 citations

Peripheral and spinal mechanisms of nociception.

1987 • 1,025 citations

Antidepressant-induced analgesia in chronic non-malignant pain: a meta-analysis of 39 placebo-controlled studies

1992 • 562 citations

Spinal serotonin terminal system mediates antinociception

1981 • 504 citations

Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception.

1995 • 362 citations

Behavioural despair in mice : A primary screening test for antidepressants

1977 • 333 citations

Spinal noradrenergic terminal system mediates antinociception

1980 • 317 citations

Frontiers in Biochemical and Pharmacological Research in Depression

1984 • 278 citations

TREATMENT OF CHRONIC TENSION HEADACHE

1964 • 271 citations

Pain relief by antidepressants: Possible modes of action

1985 • 242 citations

Role of the serotonergic system in the forced swimming test

1995 • 241 citations

Amitriptyline potentiates morphine analgesia by a direct action on the central nervous system

1983 • 190 citations

Analgesic activity of tricyclic antidepressants

1983 • 166 citations

Noradrenaline regulation of pain-transmission in the spinal cord mediated by α-adrenoceptors

1979 • 158 citations

Antinociceptive effects of acute and ‘chronic’ injections of tricyclic antidepressant drugs in a new model of mononeuropathy in rats

1992 • 149 citations

Antidepressants in Chronic Pain

1983 • 143 citations

Interaction of tricyclic antidepressants with opiate receptors

1980 • 139 citations

The analgesic effect of tricyclic antidepressants

1990 • 109 citations

Antidepressant drugs as adjuvant analgesics

1994 • 102 citations

Imipramine reduces experimental pain

1986 • 92 citations

Participation of opioid and monoaminergic mechanisms on the antinociceptive effect induced by tricyclic antidepressants in two behavioural pain tests in mice

1994 • 91 citations

Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis

1985 • 88 citations

Influence of naloxone and methysergide on the analgesic effect of clomipramine in rats

1981 • 88 citations

Possible involvement of opiate receptors in the pharmacological profiles of antidepressant compounds

1984 • 80 citations

The hypoalgesic effect of imipramine in different human experimental pain models

1995 • 73 citations

Hypoalgesia induced by antidepressants in mice: A case for opioids and serotonin

1986 • 65 citations

Central analgesic effects of desipramine, fluvoxamine, and moclobemide after single oral dosing: A study in healthy volunteers

1993 • 57 citations

Interaction of opioids with antidepressant-induced antinociception

1995 • 51 citations

Influence of naloxone on the antinociceptive effects of some antidepressant drugs.

1985 • 50 citations

Tricyclic antidepressants in treatment of depression and chronic pain: analysis of the supporting evidence.

1984 • 48 citations

Comparative effects of different uptake inhibitor antidepressants in two pain tests in mice

1992 • 48 citations

Comparison of Desipramine, Amitriptyline, Zimeldine and Alaproclate in Six Animal Models Used to Investigate Antidepressant Drugs

1988 • 43 citations

Pharmacokinetic patterns of repeated administration of antidepressants in animals. I. Implications for antinociceptive action of clomipramine in mice.

1988 • 40 citations

Involvement of bulbospinal pathways in the antinociceptive effect of clomipramine in the rat

1995 • 40 citations

Chlomipramine differently affects inflammatory edema and pain in the rat

1994 • 36 citations

Activities of five antidepressants in a behavioral pain test in rats

1983 • 36 citations

Noradrenergic and opioidergic influences on the antinociceptive effect of clomipramine in the formalin test in rats

1989 • 35 citations

Effect of p‐Chlorophenylalanine and α‐Methyltyrosine on the Antinociceptive Effect of Antidepressant Drugs

1995 • 35 citations

Evidence for a central but not a peripheral analgesic effect of clomipramine in rats

1991 • 34 citations

Clinical pharmacology of antidepressant drugs: pharmacogenetics.

1984 • 33 citations

Why Are Antidepressants Effective As Pain Relief?

1994 • 33 citations

ANTIDEPRESSANT DRUGS AND EXPERIMENTAL INFLAMMATION

1996 • 28 citations

Similar Effects of Acetylsalicylic Acid and Morphine on Immediate Responses to Acute Noxious Stimulation

1987 • 26 citations

Pharmacology of Antidepressants

1987 • 26 citations

Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants

1987 • 25 citations

Site- and test-dependent antinociceptive efficacy of amitriptyline in rats

1994 • 23 citations

Serotonin and depression: Old problems and new data

1989 • 21 citations

Acute and chronic treatment with selective serotonin uptake inhibitors in mice: effects on nociceptive sensitivity and response to 5-methoxy- N, N -dimethyltryptamine

1988 • 19 citations

Enhancement of propoxyphene-induced analgesia by doxepin

1977 • 12 citations

Effects of Desipramine and Chlorimipramine on Buprenorphine Analgesia in Mice

1986 • 11 citations

Antinociceptive activity of metapramine in mice. Relationship with its pharmacokinetic properties

1992 • 8 citations

Studies on the potentiation of the antinociceptive effect of oxotremorine by tetrabenazine in mice

1974 • 5 citations