Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis

A method for measurement of analgesic activity on inflamed tissue.

1957 • 1,558 citations

CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT

1963 • 523 citations

Effects of capsaicin on inflammation and on the substance P content of nervous tissues in rats with adjuvant arthritis

1983 • 216 citations

Amitriptyline potentiates morphine analgesia by a direct action on the central nervous system

1983 • 190 citations

Progress in Tryptophan and Serotonin Research

1984 • 184 citations

Morphine analgesia in the tail-flick and Formalin pain tests is mediated by different neural systems

1982 • 169 citations

Further evidence validating adjuvant arthritis as an experimental model of chronic pain in the rat

1982 • 158 citations

Electrophysiological characteristics of dorsal horn cells in rats with cutaneous inflammation resulting from chronic arthritis

1982 • 156 citations

The analgesic effects of morphine, but not those of the enkephalinase inhibitor thiorphan, are enhanced in arthritic rats

1983 • 155 citations

A new method for the evaluation of analgesic activity using adjuvant-induced arthritis in the rat

1975 • 150 citations

Dose-dependent analgesic and hyperalgesic effects of systemic naloxone in arthritic rats

1981 • 149 citations

Chronic antidepressant treatment and central 5-HT synapses

1983 • 142 citations

Met-enkephalin levels and opiate receptors in the spinal cord of chronic suffering rats

1980 • 131 citations

Reaction thresholds to pressure in edematous hindpaws of rats and responses to analgesic drugs.

1965 • 126 citations

A controlled study of amitriptyline in the treatment of chronic pain

1982 • 124 citations

Substance P in sensory nerve fibres contributes to the development of oedema in the rat hind paw after thermal injury

1984 • 121 citations

The formalin test: A tonic pain model in the primate

1984 • 97 citations

Can chronic pain be suppressed despite purported tolerance to narcotic analgesia?

1979 • 97 citations

Influence of naloxone and methysergide on the analgesic effect of clomipramine in rats

1981 • 88 citations

Illness behavior and depression compared in pain center and private practice patients

1979 • 86 citations

Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia

1980 • 74 citations

Somatic responses of ventrobasal thalamic neurones in polyarthritic rats

1982 • 72 citations

Use of Freund's adjuvant arthritis test in anti-flammatory drug screening in the rat: value of animal selection and preparation at the breeding center.

1976 • 72 citations

The relief of pain with an antidepressant in arthritis.

1969 • 69 citations

A clinical trial of Tofranil in rheumatic pain in general practice.

1976 • 67 citations

Altered properties and laminar distribution of neuronal responses to peripheral stimulation in the Sml cortex of the arthritic rat

1983 • 63 citations

Serotonin and the regulation of pituitary hormone secretion and of neuroendocrine rhythms.

1981 • 58 citations

Role of the Raphe Nuclei in Stimulation Producing Analgesia

1981 • 51 citations

Inhibition of prostaglandin synthetase by psychotropic drugs

1975 • 46 citations

Spinal 5‐HT or NA Uptake Inhibition Potentiates Supraspinal Morphine Antinociception in Rats

1984 • 45 citations

A STUDY OF THE INFLUENCE OF VARIOUS ANTIRHEUMATIC DRUG REGIMENS ON SERUM ACUTE-PHASE PROTEINS, PLASMA TRYPTOPHAN, AND ERYTHROCYTE SEDIMENTATION RATE IN RHEUMATOID ARTHRITIS

1975 • 41 citations

Effects of doxepin on perception of laboratory-induced pain in man

1978 • 39 citations

Activities of five antidepressants in a behavioral pain test in rats

1983 • 36 citations

An appraisal of the interrelationships between prostaglandins and cyclic nucleotides in inflammation.

1976 • 32 citations

Total and free serum tryptophan levels and brain 5-hydroxytryptamine metabolism in arthritic rats

1980 • 22 citations

Pharmacological evidence of a possible tryptaminergic regulation of opiate receptors by using indalpine, a selective 5-HT uptake inhibitor

1980 • 17 citations

A Possible involvement of the central endorphin system in the autoanalgesia induced by chronic administration of freundʼs adjuvant solution in rats

1983 • 17 citations

Effect of tricyclic antidepressants on analgesic activity in laboratory animals.

1980 • 16 citations

Recent Advances in the Management of Pain

1985 • 12 citations

Relief of Intractable Pain

1975 • 11 citations

Some aspects of the interrelationship between central 5-hydroxytryptamine neurons and hormones.

1974 • 11 citations

Cholinergic receptors of rat lymphocytes during adjuvant polyarthritis

1982 • 11 citations

[Analgesic properties and plasma concentrations of clomipramine in chronic pain].

1983 • 7 citations

Is there any relationship between antinociception, doses and plasma levels of clomipramine during subchronic treatment in rats?

1984 • 7 citations

Imipramine in the Treatment of Rheumatic Patients

1962 • 6 citations

Changes in total and free tryptophan levels in serum following acute morphine administration in arthritic rats

1981 • 6 citations

The pharmacological consequences of the binding of anti-rheumatic drugs to plasma proteins in the treatment of rheumatoid arthritis

1979 • 5 citations

Variations in levels of cyclic AMP and GMP in the thymus, spleen and mesenteric lymph node of rats after the induction of adjuvant arthritis

1980 • 4 citations

The mechanism of action of antirheumatic agents.

1979 • 4 citations

Effect of tricyclic antidepressants (acute and chronic) on morphine analgesia in rats with adjuvant-induced arthritis

1984 • 2 citations

[Endomorphins and experimental analgesic action of amitriptyline].

1983 • 2 citations