The influence of age and gender on serum dehydroepiandrosterone sulphate (DHEA-S), IL-6, IL-6 soluble receptor (IL-6 sR) and transforming growth factor beta 1 (TGF-β1) levels in normal healthy blood donors

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

Bone Marrow, Cytokines, and Bone Remodeling — Emerging Insights into the Pathophysiology of Osteoporosis

1995 • 1,661 citations

Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood

1984 • 1,345 citations

Marked Decline in Serum Concentrations of Adrenal C19 Sex Steroid Precursors and Conjugated Androgen Metabolites During Aging

1997 • 688 citations

Increased cytokine production in mononuclear cells of healthy elderly people

1993 • 648 citations

Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative.

1993 • 577 citations

The Association of Plasma IL-6 Levels With Functional Disability in Community-Dwelling Elderly

1997 • 476 citations

Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans.

1981 • 473 citations

Interleukin‐6: A Cytokine for Gerontolgists

1993 • 457 citations

Increase of plasma IL-6 concentration with age in healthy subjects

1992 • 393 citations

Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men.

1992 • 391 citations

Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men.

1994 • 387 citations

Serum Dehydroepiandrosterone (DHEA) and DHEA Sulfate Are Negatively Correlated with Serum Interleukin-6 (IL-6), and DHEA Inhibits IL-6 Secretion from Mononuclear Cells in Manin Vitro: Possible Link between Endocrinosenescence and Immunosenescence

1998 • 328 citations

Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction.

1993 • 322 citations

Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects

1997 • 320 citations

Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated ‘acute phase response’ in the brain?

1991 • 267 citations

Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1β or IL-1RA but increases in the associated acute phase proteins IL-6, α2-macroglobulin and C-reactive protein

1993 • 243 citations

Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men

1994 • 240 citations

Replacement of DHEA in Aging Men and Women

1995 • 239 citations

Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women

1993 • 212 citations

Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men

1992 • 207 citations

Marked Decline in Serum Concentrations of Adrenal C19 Sex Steroid Precursors and Conjugated Androgen Metabolites During Aging

1997 • 181 citations

Dysregulation between TH1 and TH2 T cell subpopulations in the elderly

1996 • 178 citations

Interleukin-6 and selected plasma proteins in healthy persons of different ages

1994 • 176 citations

Soluble IL-6 Receptor Potentiates the Antagonistic Activity of Soluble gp130 on IL-6 Responses

1998 • 163 citations

Activation of Immune Function by Dehydroepiandrosterone (DHEA) in Age-Advanced Men

1997 • 161 citations

Cytokine production pathway in the elderly

1996 • 138 citations

Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis.

1992 • 133 citations

Immunosenescence: ageing of the immune system

1995 • 113 citations

Increase of interleukin 6 and decrease of interleukin 2 production during the ageing process are influenced by the health status

1998 • 108 citations

Serum Dehydroepiandrosterone (DHEA) and DHEA Sulfate Are Negatively Correlated with Serum Interleukin-6 (IL-6), and DHEA Inhibits IL-6 Secretion from Mononuclear Cells in Man in Vitro: Possible Link between Endocrinosenescence and Immunosenescence

1998 • 105 citations

Dehydroepiandrosterone metabolism.

1996 • 104 citations

Dehydroepiandrosterone and Diseases of Aging

1996 • 102 citations

Interleukin 6 gene transcripts are expressed in atherosclerotic lesions of genetically hyperlipidemic rabbits

1992 • 92 citations

Dysregulation of IL-10 production with aging: Possible linkage to the age-associated decline in DHEA and its sulfated derivative

1996 • 87 citations

THE METABOLISM OF CORTISOL-4-C¹⁴IN YOUNG AND ELDERLY MEN. I. SECRETION RATE OF CORTISOL AND DAILY EXCRETION OF TETRAHYDROCORTISOL, ALLOTETRAHYDROCORTISOL, TETRAHYDROCORTISONE AND CORTOLONE (20α AND 20β)*

1961 • 83 citations

The IMMULITE assay tube: a new approach to heterogeneous ligand assay

1991 • 80 citations

Immunodeficiency of Aging

1997 • 80 citations

γ-Interferon, Interleukin-4 and Interleukin-6 In Vitro Production in Old Subjects

1993 • 64 citations

Metabolism and Interconversion of Dehydroisoandrosterone and Dehydroisoandrosterone Sulfate

1972 • 55 citations

Sex Difference in the Metabolism of Dehydroisoandrosterone Sulfate*

1980 • 53 citations

IL-6, DHEA and the ageing process

1997 • 47 citations

DHEA

1996 • 36 citations

The discriminant-function test: a marker of Th1/Th2 cell cytokine secretion and breast tumour oestrogen synthesis

1995 • 20 citations

Dehydroepiandrosterone induces the transforming growth factor-beta production by murine macrophages.

1997 • 17 citations