The discriminant-function test: a marker of Th1/Th2 cell cytokine secretion and breast tumour oestrogen synthesis

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1960 • 10,428 citations

Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood

1984 • 1,345 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative.

1993 • 577 citations

Increase of plasma IL-6 concentration with age in healthy subjects

1992 • 393 citations

Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function.

1990 • 349 citations

A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription.

1993 • 337 citations

Molecular Properties of Corticosteroid Binding Globulin and the Sex-Steroid Binding Proteins*

1990 • 312 citations

Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance

1994 • 286 citations

The importance of local synthesis of estrogen within the breast

1987 • 280 citations

Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women

1993 • 212 citations

THE RELATIONSHIP BETWEEN 17β‐HYDROXYSTEROID DEHYDROGENASE ACTIVITY AND OESTROGEN CONCENTRATIONS IN HUMAN BREAST TUMOURS AND IN NORMAL BREAST TISSUE

1983 • 188 citations

A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription [published erratum appears in J Clin Endocrinol Metab 1994 Feb;78(2):494]

1993 • 172 citations

SELECTION OF BREAST-CANCER PATIENTS FOR ADRENALECTOMY OR HYPOPHYSECTOMY BY DETERMINATION OF URINARY 17-HYDROXYCORTICOSTEROIDS AND ÆTIOCHOLANOLONE

1960 • 165 citations

Macrophages in human breast disease: a quantitative immunohistochemical study

1988 • 160 citations

in situ oestrone synthesis in normal breast and breast tumour tissues: Effect of treatment with 4‐hydroxyandrostenedione

1989 • 157 citations

ABNORMAL URINARY STEROID EXCRETION AND SUBSEQUENT BREAST CANCER

1967 • 118 citations

Plasma levels of estrone, estrone sulfate, and estradiol and the percentage of unbound estradiol in postmenopausal women with and without breast disease.

1983 • 117 citations

Control of aromatase activity in breast cancer cells: The role of cytokines and growth factors

1993 • 113 citations

11β-Hydroxysteroid dehydrogenase and the short-chain alcohol dehydrogenase (SCAD) superfamily

1992 • 100 citations

INTERLEUKIN-1 AND INTERLEUKIN-6 IN BREAST CYST FLUID: THEIR ROLE IN REGULATING AROMATASE ACTIVITY IN BREAST CANCER CELLS

1992 • 96 citations

Interleukin 6 is secreted by breast fibroblasts and stimulates 17β‐oestradiol oxidoreductase activity of MCF‐7 cells: Possible paracrine regulation of breast 17β‐oestradiol levels

1991 • 77 citations

Prevention by dehydroepiandrosterone of the development of mammary carcinoma induced by 7,12-dimethylbenz(a)anthracene (DMBA) in the rat

1994 • 72 citations

The interaction of cytokines in regulating oestradiol 17β-hydroxysteroid dehydrogenase activity in MCF-7 cells

1994 • 64 citations

Aromatization of steroids in peripheral tissues

1983 • 59 citations

The conversion of androstenedione to oestrone and production of oestrone in women with endometrial cancer

1979 • 45 citations

Factors influencing aromatase activity in the breast

1993 • 40 citations

Identification of breast cancer transcortin and its inhibitory role in cell-mediated immunity

1976 • 30 citations

The relationship between 17β hydroxysteroid dehydrogenase and breast tumour site and size

1985 • 29 citations

The Effect of Glucocorticoids on theIn VivoConversion of Androstenedione to Oestrone

1986 • 20 citations

Conversion of estrone to estradiol and estradiol to estrone in postmenopausal women.

1985 • 12 citations