Identification of an Overlapping Binding Domain on Cdc20 for Mad2 and Anaphase-Promoting Complex: Model for Spindle Checkpoint Regulation

Feedback control of mitosis in budding yeast

1991 • 1,167 citations

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

1991 • 1,125 citations

A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

1995 • 964 citations

Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1

1999 • 929 citations

CDC20 and CDH1 : A Family of Substrate-Specific Activators of APC-Dependent Proteolysis

1997 • 809 citations

Association of Spindle Assembly Checkpoint Component XMAD2 with Unattached Kinetochores

1996 • 785 citations

Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

1992 • 784 citations

Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.

1996 • 777 citations

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

1995 • 745 citations

How Cells Get the Right Chromosomes

1997 • 625 citations

Identification of a Human Mitotic Checkpoint Gene: hsMAD2

1996 • 609 citations

An ESP1/PDS1 Complex Regulates Loss of Sister Chromatid Cohesion at the Metaphase to Anaphase Transition in Yeast

1998 • 594 citations

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

1998 • 590 citations

Budding Yeast Cdc20: A Target of the Spindle Checkpoint

1998 • 561 citations

Kinetochore Localization of Murine Bub1 Is Required for Normal Mitotic Timing and Checkpoint Response to Spindle Damage

1997 • 543 citations

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

1998 • 528 citations

Chromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2

2000 • 523 citations

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

1998 • 488 citations

Yeast Hct1 Is a Regulator of Clb2 Cyclin Proteolysis

1997 • 479 citations

The Human Homologue of Bub3 Is Required for Kinetochore Localization of Bub1 and a Mad3/Bub1-related Protein Kinase

1998 • 460 citations

Splitting the Chromosome: Cutting the Ties That Bind Sister Chromatids

2000 • 429 citations

The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint.

1996 • 422 citations

The spindle checkpoint

1999 • 408 citations

Fission Yeast Slp1: An Effector of the Mad2-Dependent Spindle Checkpoint

1998 • 381 citations

Human Bubr1 Is a Mitotic Checkpoint Kinase That Monitors Cenp-E Functions at Kinetochores and Binds the Cyclosome/APC

1999 • 379 citations

The spindle assembly checkpoint

1996 • 364 citations

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).

1996 • 357 citations

APCCdc20 promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5

1999 • 346 citations

Activation of the Budding Yeast Spindle Assembly Checkpoint Without Mitotic Spindle Disruption

1996 • 341 citations

Spindle Checkpoint Protein Xmad1 Recruits Xmad2 to Unattached Kinetochores

1998 • 307 citations

Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20.

2000 • 199 citations

Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage

1999 • 184 citations

The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae.

1995 • 180 citations

The Spindle Checkpoint of Budding Yeast Depends on a Tight Complex between the Mad1 and Mad2 Proteins

1999 • 175 citations

Budding Yeast Bub2 Is Localized at Spindle Pole Bodies and Activates the Mitotic Checkpoint via a Different Pathway from Mad2

1999 • 155 citations

Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome

1999 • 144 citations

Mad2 transiently associates with an APC/p55Cdc complex during mitosis

1998 • 125 citations

Proteolytic ratchets that control progression through mitosis

1998 • 122 citations

A Bub2p-dependent spindle checkpoint pathway regulates the Dbf2p kinase in budding yeast

1999 • 115 citations

p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase

2000 • 59 citations

p21Waf1/cip1 acts in synergy with bcl-2 to confer multidrug resistance in a camptothecin-selected human lung-cancer cell line

1999 • 43 citations