Systemic and Nasal Delivery of Orexin-A (Hypocretin-1) Reduces the Effects of Sleep Deprivation on Cognitive Performance in Nonhuman Primates

Applied Linear Statistical Models

1992 • 10,206 citations

THE [¹⁴C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT¹

1977 • 5,986 citations

Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

1998 • 3,381 citations

Narcolepsy in orexin Knockout Mice

1999 • 3,014 citations

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

1999 • 2,583 citations

Tomographic measurement of local cerebral glucose metabolic rate in humans with (F‐18)2‐fluoro‐2‐deoxy‐D‐glucose: Validation of method

1979 • 2,396 citations

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

2000 • 2,065 citations

Reduced Number of Hypocretin Neurons in Human Narcolepsy

2000 • 2,004 citations

MRI-PET Registration with Automated Algorithm

1993 • 1,654 citations

Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

2001 • 1,387 citations

Orexin A activates locus coeruleus cell firing and increases arousal in the rat

1999 • 1,182 citations

CELL BIOLOGY OF ANTIGEN PROCESSING IN VITRO AND IN VIVO

2005 • 1,108 citations

Distribution of orexin neurons in the adult rat brain

1999 • 1,052 citations

Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity

2000 • 1,022 citations

Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle

2005 • 840 citations

Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons

2005 • 830 citations

Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation

1993 • 655 citations

Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system

1999 • 587 citations

Presynaptic and Postsynaptic Actions and Modulation of Neuroendocrine Neurons by a New Hypothalamic Peptide, Hypocretin/Orexin

1998 • 562 citations

Promotion of sleep by targeting the orexin system in rats, dogs and humans

2007 • 557 citations

Hypocretin (orexin) cell loss in Parkinson's disease

2007 • 524 citations

Hypothalamic Hypocretin (Orexin): Robust Innervation of the Spinal Cord

1999 • 522 citations

Hypocretin-1 Modulates Rapid Eye Movement Sleep through Activation of Locus Coeruleus Neurons

2000 • 506 citations

Anatomical substrates of orexin–dopamine interactions: lateral hypothalamic projections to the ventral tegmental area

2002 • 499 citations

The hypocretin/orexin ligand–receptor system: implications for sleep and sleep disorders

2000 • 451 citations

Fluctuation of extracellular hypocretin‐1 (orexin A) levels in the rat in relation to the light–dark cycle and sleep–wake activities

2001 • 441 citations

Hypocretin (orexin) loss in Parkinson's disease

2007 • 433 citations

Our Reviewers

2004 • 359 citations

The novel brain neuropeptide, orexin‐A, modulates the sleep–wake cycle of rats

2000 • 338 citations

Release of Hypocretin (Orexin) during Waking and Sleep States

2002 • 335 citations

Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

2004 • 334 citations

Orexin A but not orexin B rapidly enters brain from blood by simple diffusion.

1999 • 312 citations

SB‐334867‐A: the first selective orexin‐1 receptor antagonist

2001 • 311 citations

The Effects of Total Sleep Deprivation on Cerebral Responses to Cognitive Performance

2001 • 302 citations

Hypocretin-2-Saporin Lesions of the Lateral Hypothalamus Produce Narcoleptic-Like Sleep Behavior in the Rat

2001 • 273 citations

Circadian and Homeostatic Regulation of Hypocretin in a Primate Model: Implications for the Consolidation of Wakefulness

2003 • 270 citations

Local cerebral glucose utilization in the normal conscious macaque monkey

1978 • 246 citations

Noninvasive quantitative fluorodeoxyglucose PET studies with an estimated input function derived from a population-based arterial blood curve.

1993 • 198 citations

Hypocretin/Orexin Selectively Increases Dopamine Efflux within the Prefrontal Cortex: Involvement of the Ventral Tegmental Area

2005 • 180 citations

Diurnal variation in orexin A immunoreactivity and prepro-orexin mRNA in the rat central nervous system

2000 • 172 citations

The neurotransmitters of sleep.

2004 • 159 citations

Facilitation of Task Performance and Removal of the Effects of Sleep Deprivation by an Ampakine (CX717) in Nonhuman Primates

2005 • 154 citations

Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement

2002 • 146 citations

Peptides crossing the blood–brain barrier: some unusual observations

1999 • 140 citations

Hypocretin and Nicotine Excite the Same Thalamocortical Synapses in Prefrontal Cortex: Correlation with Improved Attention in Rat

2005 • 128 citations

Functional inactivation of orexin 1 receptors in CA1 region impairs acquisition, consolidation and retrieval in Morris water maze task

2006 • 118 citations

Increased and Decreased Muscle Tone With Orexin (Hypocretin) Microinjections in the Locus Coeruleus and Pontine Inhibitory Area

2001 • 114 citations

Categorization in the monkey hippocampus: A possible mechanism for encoding information into memory

2004 • 112 citations

Binding interactions between peptides and proteins of the class II Major Histocompatibility Complex

2002 • 110 citations

Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs.

2000 • 107 citations

Excitatory Effects of Hypocretin-1 (Orexin-A) in the Trigeminal Motor Nucleus Are Reversed by NMDA Antagonism

2003 • 99 citations

SB-334867-A antagonises orexin mediated excitation in the locus coeruleus

2002 • 86 citations

Template Images for Nonhuman Primate Neuroimaging: 2. Macaque

2001 • 56 citations

The Orexin-1 Receptor Antagonist SB-334867 Blocks the Effects of Antipsychotics on the Activity of A9 and A10 Dopamine Neurons: Implications for Antipsychotic Therapy

2006 • 54 citations

Intravenously administered hypocretin-1 alters brain amino acid release: an in vivo microdialysis study in rats

2003 • 47 citations