SB-334867-A antagonises orexin mediated excitation in the locus coeruleus

The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

1998 • 3,711 citations

Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

1998 • 3,381 citations

Differential expression of orexin receptors 1 and 2 in the rat brain

2001 • 1,593 citations

Orexin A activates locus coeruleus cell firing and increases arousal in the rat

1999 • 1,182 citations

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

1999 • 1,028 citations

Distribution of orexin receptor mRNA in the rat brain

1998 • 982 citations

Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system

1999 • 587 citations

Presynaptic and Postsynaptic Actions and Modulation of Neuroendocrine Neurons by a New Hypothalamic Peptide, Hypocretin/Orexin

1998 • 562 citations

Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord

2001 • 457 citations

Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action1This study was presented in part at the 28th Annual Meeting of the Society for Neuroscience, Los Angeles, CA, in November 1998.1

1999 • 337 citations

A selective orexin-1 receptor antagonist reduces food consumption in male and female rats

2000 • 324 citations

SB‐334867‐A: the first selective orexin‐1 receptor antagonist

2001 • 311 citations

Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat

2001 • 267 citations

Orexin-A, an hypothalamic peptide with analgesic properties

2001 • 260 citations

SB‐334867, a selective orexin‐1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin‐A in rats

2001 • 230 citations

Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell‐line using FLIPR

1999 • 185 citations

Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons

2000 • 166 citations

Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats

2001 • 148 citations

Substance P opens cation channels and closes potassium channels in rat locus coeruleus neurons

1992 • 126 citations

Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity

2001 • 104 citations

Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX 1 ) receptors, with downstream 5-HT 2C receptor involvement

2001 • 93 citations

Efficacy in drug receptor theory: outdated concept or under-valued tool?

1999 • 52 citations