Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs.

Narcolepsy in orexin Knockout Mice

1999 • 3,014 citations

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

1999 • 2,583 citations

Orexin A activates locus coeruleus cell firing and increases arousal in the rat

1999 • 1,182 citations

Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system

1999 • 587 citations

Medullary regions mediating atonia

1988 • 362 citations

Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action1This study was presented in part at the 28th Annual Meeting of the Society for Neuroscience, Los Angeles, CA, in November 1998.1

1999 • 337 citations

Orexin Synthesis and Response in the Gut

1999 • 329 citations

Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats

1999 • 320 citations

Orexin A but not orexin B rapidly enters brain from blood by simple diffusion.

1999 • 312 citations

Narcolepsy

1999 • 239 citations

Locus coeruleus neurons: cessation of activity during cataplexy

1999 • 225 citations

Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight

1999 • 215 citations

Stimulation of Gastric Acid Secretion by Centrally Administered Orexin-A in Conscious Rats

1999 • 199 citations

Neuronal Activity in Narcolepsy: Identification of Cataplexy-Related Cells in the Medial Medulla

1991 • 162 citations

Diagnostic aspects of narcolepsy

1998 • 88 citations

Sleep studies on canine narcolepsy: Pattern and cycle comparisons between affected and normal dogs

1977 • 82 citations

Sleep cycle organization in narcoleptic and normal dogs

1979 • 41 citations

Narcolepsy.

1992 • 16 citations