β-Cell Death and Mass in Syngeneically Transplanted Islets Exposed to Short- and Long-Term Hyperglycemia

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

2000 • 5,125 citations

Apoptosis, oncosis, and necrosis. An overview of cell death.

1995 • 3,325 citations

Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol

2001 • 864 citations

Vulnerability of Islets in the Immediate Posttransplantation Period: Dynamic Changes in Structure and Function

1996 • 459 citations

Effect of Hypoxia on Insulin Secretion by Isolated Rat and Canine Islets of Langerhans

1993 • 418 citations

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

1999 • 401 citations

ISLET CELL DAMAGE ASSOCIATED WITH TACROLIMUS AND CYCLOSPORINE: MORPHOLOGICAL FEATURES IN PANCREAS ALLOGRAFT BIOPSIES AND CLINICAL CORRELATION1

1999 • 341 citations

Reducing sugars trigger oxidative modification and apoptosis in pancreatic β-cells by provoking oxidative stress through the glycation reaction

1996 • 254 citations

Glucose stimulates protein modification by O -linked GlcNAc in pancreatic β cells: Linkage of O -linked GlcNAc to β cell death

2000 • 240 citations

Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy.

2000 • 221 citations

Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas.

1995 • 209 citations

Structural and functional changes resulting from islet isolation lead to islet cell death

1999 • 201 citations

Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice.

1993 • 199 citations

Critical Mass of Purified Islets That Induce Normoglycemia After Implantation Into Dogs

1988 • 135 citations

Pancreatic islet cell survival following islet isolation: the role of cellular interactions in the pancreas

1999 • 134 citations

Islet Mass and Function in Diabetes and Transplantation

1990 • 124 citations

Beneficial Influence of Glycemic Control Upon the Growth and Function of Transplanted Islets

1994 • 111 citations

Long Term Effects of Aminoguanidine on Insulin Release and Biosynthesis: Evidence That the Formation of Advanced Glycosylation End Products Inhibits B Cell Function¹

1997 • 109 citations

The renal subcapsular site offers better growth conditions for transplanted mouse pancreatic islet cells than the liver or spleen

1986 • 105 citations

International islet transplant registry report

1996 • 95 citations

Hyperglycemia-induced B cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background.

1990 • 92 citations

ENDOTOXIN CONTAMINATION MAY BE RESPONSIBLE FOR THE UNEXPLAINED FAILURE OF HUMAN PANCREATIC ISLET TRANSPLANTATION1

1998 • 79 citations

Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis.

1995 • 72 citations

Effect of hypoxia on insulin secretion by isolated rat and canine islets of Langerhans

1993 • 72 citations

Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice.

1995 • 71 citations

Transplanted beta cell response to increased metabolic demand. Changes in beta cell replication and mass.

1994 • 62 citations

Blood flow measurements in autotransplanted pancreatic islets of the rat. Impairment of the blood perfusion of the graft during hyperglycemia.

1987 • 50 citations

The effect of prednisone on pancreatic islet autografts in dogs.

1993 • 41 citations

Islet mass and function in diabetes and transplantation

1990 • 40 citations

Critical mass of purified islets that induce normoglycemia after implantation into dogs

1988 • 39 citations

Improved outcome of islet transplantation in insulin-treated diabetic mice: effects on beta-cell mass and function

1997 • 37 citations

Insulin Secretory Function in Relation to Transplanted Islet Mass in STZ-Induced Diabetic Rats

1993 • 32 citations

Effect of donor islet mass on metabolic normalization in streptozotocin-diabetic rats

1992 • 32 citations

Optimal Insulin Treatment in Syngeneic Islet Transplantation

2000 • 32 citations

Beneficial influence of glycemic control upon the growth and function of transplanted islets

1994 • 30 citations

Protection of mouse islet isografts from nonspecific inflammatory damage by recipient treatment with nicotinamide and 15-deoxyspergualin

1996 • 29 citations

Normoglycemia Restores β-Cell Replicative Response to Glucose in Transplanted Islets Exposed to Chronic Hyperglycemia

1998 • 28 citations

Mechanisms of Defective Glucose-Induced Insulin Release in Human Pancreatic Islets Transplanted to Diabetic Nude Mice¹

1997 • 27 citations

PREVENTION OF PRIMARY ISLET ISOGRAFT NONFUNCTION IN MICE WITH PRAVASTATIN1

1998 • 26 citations

Influence of Hyperglycemia on Blood Perfusion of Autotransplanted Pancreatic Islets in Diabetic Rats

1989 • 20 citations

Protection of Mouse Islet Isografts from Nonspecific Inflammatory Damage by Recipient Treatment with Nicotinamide and 15-Deoxyspergualin

1996 • 20 citations

Mechanisms of Defective Glucose-Induced Insulin Release in Human Pancreatic Islets Transplanted to Diabetic Nude Mice

1997 • 18 citations

ON THE VARIABILITY OF OUTCOME AFTER ISLET ALLOTRANSPLANTATION

1988 • 15 citations

THE AMELIORATION OF HYPERGLYCEMIA IN STREPTOZOTOCIN-INDUCED DIABETIC RATS AFTER THE INTRAPORTAL TRANSPLANTATION OF AN INSUFFICIENT NUMBER OF ISLETS BY NICOTINAMIDE TREATMENT

1995 • 13 citations

Insulin secretory function in relation to transplanted islet mass in STZ-induced diabetic rats

1993 • 9 citations

Normoglycemia restores beta-cell replicative response to glucose in transplanted islets exposed to chronic hyperglycemia

1998 • 5 citations

Preserved beta cell function with insulin treatment in islet transplantation: effect on insulin gene expression

1999 • 4 citations