Cotranslocation and Colocalization of hsp40 (DnaJ) with hsp70 (DnaK) in Mammalian Cells.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

Protein folding in the cell

1992 • 4,138 citations

Speculations on the functions of the major heat shock and glucose-regulated proteins

1986 • 1,574 citations

A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides

1988 • 1,504 citations

Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

1990 • 1,293 citations

70K heat shock related proteins stimulate protein translocation into microsomes

1988 • 1,276 citations

Heat shock, from bacteria to man

1982 • 1,260 citations

Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease

1992 • 1,201 citations

Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding

1992 • 965 citations

Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK.

1991 • 835 citations

Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones

1994 • 651 citations

DnaK, DnaJ and GrpE form a cellular chaperone machinery capable of repairing heat-induced protein damage.

1993 • 593 citations

Nuclear and nucleolar localization of the 72,000-dalton heat shock protein in heat-shocked mammalian cells.

1984 • 522 citations

DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70

1994 • 473 citations

Hsp70 accelerates the recovery of nucleolar morphology after heat shock.

1984 • 456 citations

Morphological study of the mammalian stress response: characterization of changes in cytoplasmic organelles, cytoskeleton, and nucleoli, and appearance of intranuclear actin filaments in rat fibroblasts after heat-shock treatment.

1985 • 428 citations

The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner

1990 • 407 citations

Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins

1989 • 358 citations

1 Progress and Perspectives on the Biology of Heat Shock Proteins and Molecular Chaperones

1994 • 342 citations

Interaction of hsp70 with unfolded proteins: effects of temperature and nucleotides on the kinetics of binding.

1991 • 332 citations

A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome.

1993 • 290 citations

YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism

1992 • 280 citations

Regulation of Hsp70 function by a eukaryotic DnaJ homolog.

1992 • 262 citations

The emergence of the chaperone machines

1992 • 249 citations

The Escherichia coli DnaK chaperone, the 70-kDa heat shock protein eukaryotic equivalent, changes conformation upon ATP hydrolysis, thus triggering its dissociation from a bound target protein

1991 • 245 citations

Eukaryotic DnaJ homologs and the specificity of Hsp70 activity

1993 • 228 citations

Eukaryotic homologues of Escherichia coli dnaJ: a diverse protein family that functions with hsp70 stress proteins.

1993 • 225 citations

Cooperation of GroEL/GroES and DnaK/DnaJ heat shock proteins in preventing protein misfolding in Escherichia coli.

1992 • 214 citations

Mutational analysis of the human HSP70 protein: distinct domains for nucleolar localization and adenosine triphosphate binding.

1989 • 175 citations

Control of folding and membrane translocation by binding of the chaperone DnaJ to nascent polypeptides.

1993 • 163 citations

9 Properties of the Heat Shock Proteins of Escherichia coli and the Autoregulation of the Heat Shock Response

1994 • 137 citations

Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of DnaK and DnaJ in the endoplasmic reticulum.

1993 • 135 citations

Both the Escherichia coli chaperone systems, GroEL/GroES and DnaK/DnaJ/GrpE, can reactivate heat-treated RNA polymerase. Different mechanisms for the same activity.

1993 • 132 citations

Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons

1992 • 127 citations

A stress-inducible 40 kDa protein (hsp40): purification by modified two-dimensional gel electrophoresis and co-localization with hsc70(p73) in heat-shocked HeLa cells

1993 • 102 citations

Cloning of a cDNA for Heat-Shock Protein hsp40, a Human Homolog of Bacterial DnaJ

1993 • 95 citations

Heat shock induction of intranuclear actin rods in cultured mammalian cells

1986 • 93 citations

Disruption of the Three Cytoskeletal Networks in Mammalian Cells Does Not Affect Transcription, Translation, or Protein Translocation Changes Induced by Heat Shock

1985 • 75 citations

Regulation of 70‐kDa Heat‐Shock‐Protein ATPase Activity and Substrate Binding by Human DnaJ‐Like Proteins, HSJ1a and HSJ1b

1994 • 75 citations

Intracellular Localization and Partial Amino Acid Sequence of a Stress-Inducible 40-kDa Protein in HeLa Cells.

1992 • 72 citations

Activity of the Hsp70 chaperone complex--DnaK, DnaJ, and GrpE--in initiating phage lambda DNA replication by sequestering and releasing lambda P protein.

1992 • 69 citations

Interaction between hsp70 and hsp40, eukaryotic homologues of DnaK and DnaJ, in human cells expressing mutant‐type p53

1995 • 68 citations

Intracellular distribution of 73 000 and 72 000 dalton heat shock proteins in HeLa cells

1986 • 67 citations

The relationship between hsp 70 localization and heat resistance

1992 • 63 citations

A novel 40-kDa protein induced by heat shock and other stresses in mammalian and avian cells

1990 • 54 citations

2 Cytosolic hsp70s of Saccharomyces cerevisiae : Roles in Protein Synthesis, Protein Translocation, Proteolysis, and Regulation

1994 • 54 citations

Disruption of the three cytoskeletal networks in mammalian cells does not affect transcription, translation, or protein translocation changes induced by heat shock.

1985 • 50 citations

Possible cytoskeletal association of 69,000- and 68,000-dalton heat shock proteins and structural relations among heat shock proteins in murine mastocytoma cells.

1986 • 46 citations

Translocation of hsp-70 and Protein Synthesis during Continuous Heating at Mild Temperatures in HeLa Cells

1991 • 39 citations

Initial characterization of heat‐induced excess nuclear proteins in HeLa cells

1992 • 39 citations

Possible Cytoskeletal Association of 69,000- and 68,000-Dalton Heat Shock Proteins and Structural Relations among Heat Shock Proteins in Murine Mastocytoma Cells

1986 • 31 citations

Effect of ATP on the Release of hsp 70 and hsp 40 from the Nucleus in Heat-Shocked HeLa Cells

1993 • 25 citations

Development of thermotolerance in hsp70 induction-defective mutant of NRK cells

1992 • 15 citations

Signal transduction cascade shared by epidermal growth factor and platelet-derived growth factor is a major pathway for oncogenic transformation in NRK cells.

1992 • 11 citations

Effects of Continuous Heating at Mild Temperatures on the Translocation of Hsp70 and Protein Synthesis in NRK Cells.

1992 • 11 citations