Dendritic cell activation by danger and antigen‐specific T‐cell signalling

Dendritic cells and the control of immunity

1998 • 14,345 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow

1999 • 2,950 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

A Theory of Self-Nonself Discrimination

1970 • 1,700 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response

1997 • 1,536 citations

The Molecular and Cellular Biology of Wound Repair

1988 • 1,508 citations

Consequences of Cell Death

2000 • 1,382 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

The immune system evolved to discriminate infectious nonself from noninfectious self

1992 • 1,324 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

2000 • 908 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor

1997 • 869 citations

Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures

1997 • 860 citations

A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides

1995 • 838 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Other Functions, Other Genes

1999 • 686 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 • 653 citations

T cell defined tumor antigens

1997 • 641 citations

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

1994 • 607 citations

Cutting Edge: Heat Shock Protein (HSP) 60 Activates the Innate Immune Response: CD14 Is an Essential Receptor for HSP60 Activation of Mononuclear Cells

2000 • 561 citations

In Vivo Detection of Dendritic Cell Antigen Presentation to CD4+ T Cells

1997 • 560 citations

A NEW ANALYSIS OF ALLOGENEIC INTERACTIONS

1975 • 551 citations

Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance.

1993 • 526 citations

Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1

1994 • 505 citations

Human 60-kDa Heat-Shock Protein: A Danger Signal to the Innate Immune System

1999 • 474 citations

Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo

1997 • 459 citations

Chemokines IL-8, GROα, MCP-1, IP-10, and Mig Are Sequentially and Differentially Expressed During Phase-Specific Infiltration of Leukocyte Subsets in Human Wound Healing

1998 • 425 citations

High-level IL-12 production by human dendritic cells requires two signals

1998 • 424 citations

Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70.

1994 • 411 citations

Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation.

1983 • 400 citations

Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.

1994 • 353 citations

Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion.

1996 • 330 citations

Dermal tumour necrosis factor-alpha induces dendritic cell migration to draining lymph nodes, and possibly provides one stimulus for Langerhans' cell migration.

1992 • 327 citations

Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.

1992 • 306 citations

Human Dendritic Cells Require Exogenous Interleukin-12–Inducing Factors to Direct the Development of Naive T-Helper Cells Toward the Th1 Phenotype

1997 • 302 citations

Is cancer dangerous to the immune system?

1996 • 296 citations

Control of immune pathology by regulatory T cells

1998 • 289 citations

Does T-cell tolerance require a dedicated antigen-presenting cell?

1989 • 288 citations

BONE MARROW-DERIVED DENDRITIC CELL PROGENITORS (NLDC 145+, MHC CLASS II+, B7-1dim, B7-2−) INDUCE ALLOANTIGEN-SPECIFIC HYPORESPONSIVENESS IN MURINE T LYMPHOCYTES1,2

1995 • 281 citations

TRANCE, a Tumor Necrosis Factor Family Member Critical for CD40 Ligand–independent T Helper Cell Activation

1999 • 262 citations

A peptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family.

1989 • 246 citations

The specific direct interaction of helper T cells and antigen-presenting B cells.

1986 • 246 citations

The two-signal model of lymphocyte activation twenty-one years later

1992 • 233 citations

The “injury response”: A concept linking nonspecific injury, acute rejection, and long-term transplant outcomes

1997 • 224 citations

Coordinated events during bacteria-induced DC maturation

1999 • 219 citations

Interleukin 1 enhances T-dependent immune responses by amplifying the function of dendritic cells.

1987 • 215 citations

A fail-safe mechanism for maintaining self-tolerance.

1992 • 213 citations

Antigenic Cancer Cells Grow Progressively in Immune Hosts without Evidence for T Cell Exhaustion or Systemic Anergy

1997 • 205 citations

CD11b+ macrophages that infiltrate human epidermis after in vivo ultraviolet exposure potently produce IL-10 and represent the major secretory source of epidermal IL-10 protein.

1994 • 197 citations

Dendritic cells from mouse bone marrow: In vitro differentiation using low doses of recombinant granulocyte-macrophage colony-stimulating factor

1992 • 179 citations

Connexins: a connection with the skin

2000 • 172 citations

Expression and function of B7 on human epidermal Langerhans cells.

1993 • 166 citations

T Lymphocyte Tolerance: From Thymic Deletion to Peripheral Control Mechanisms

1998 • 158 citations

T-cell specificity for H–2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells

1980 • 153 citations

Human dendritic cells activate T lymphocytes via a CD40: CD40 ligand‐dependent pathway

1996 • 149 citations

Depletion of epidermal langerhans cells and Ia immunogenicity from tape-stripped mouse skin.

1982 • 141 citations

Activation of human peripheral blood dendritic cells induces the CD86 co‐stimulatory molecule

1995 • 137 citations

Ligation of major histocompatibility complex class II molecules mediates apoptotic cell death in resting B lymphocytes.

1993 • 116 citations

Human Cutaneous Dendritic Cells Migrate Through Dermal Lymphatic Vessels in a Skin Organ Culture Model

1996 • 114 citations

Functional expression of CD40 antigen on human epidermal Langerhans cells.

1995 • 108 citations

Induction, regulation, and function of soluble TRAP (CD40 ligand) during interaction of primary CD4⁺ CD45RA⁺ T cells with dendritic cells

1996 • 87 citations

Immunological tolerance: Danger – pathogen on the premises!

1996 • 86 citations

Dual Function of Drosophila Cells as APCs for Naive CD8+ T Cells: Implications for Tumor Immunotherapy

1996 • 84 citations

Dermal Dendritic Cells Associated with T Lymphocytes in Normal Human Skin Display an Activated Phenotype

1998 • 80 citations

Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4+ T-cell help in CD8+ T-cell responses

1994 • 80 citations

CD40‐deficient dendritic cells producing interleukin‐10, but not interleukin‐12, induce T‐cell hyporesponsiveness in vitro and prevent acute allograft rejection

1999 • 69 citations

MHC class II and CD40 play opposing roles in dendritic cell survival

2000 • 65 citations

Induction of costimulatory molecule B7 in M12 B lymphomas by cAMP or MHC-restricted T cell interaction.

1993 • 65 citations

Adhesive and/or Signaling Functions of CD44 Isoforms in Human Dendritic Cells

1998 • 55 citations

CD40-Ligated Dendritic Cells Effectively Expand Melanoma-Specific CD8+ CTLs and CD4+ IFN-γ-Producing T Cells from Tumor-Infiltrating Lymphocytes

2000 • 52 citations

Functions of myeloid and lymphoid dendritic cells

2000 • 52 citations

Distribution of HLA class II molecules in epidermal Langerhans cells in situ

1995 • 42 citations

Differential susceptibility to CD95 (Apo-1/Fas) and MHC class II-induced apoptosis during murine dendritic cell development

2000 • 40 citations

Gap junctions: a novel route for direct cell–cell communication in the immune system?

1998 • 37 citations

T cell-dependent secretion of IL-1 beta by a dendritic cell line (XS52) derived from murine epidermis.

1995 • 34 citations

Altered CD40 ligand induction in tolerant T lymphocytes

1995 • 32 citations

Induction of dendritic cell costimulator molecule expression is suppressed by T cells in the absence of antigen‐specific signalling: role of cluster formation, CD40 and HLA‐class II for dendritic cell activation

1999 • 30 citations

Triggering HLA-DR Molecules on Human Peripheral Monocytes Induces Their Death

1999 • 29 citations

Dendritic cells need T cell help to prime cytotoxic T cell responses to strong antigens

1999 • 29 citations

Physical Interaction Between Langerhans Cells and T-Lymphocytes During Antigen Presentation In Vitro

1993 • 22 citations

Cutting edge: terra firma: a retreat from "danger".

1996 • 22 citations

Morphostasis: an evolving perspective

1997 • 21 citations

Constitutive expression of B7-1 (CD80) on mouse keratinocytes does not prevent development of chemically induced skin papillomas and carcinomas.

1996 • 20 citations

Reply from Ephraim Fuchs

1993 • 13 citations

Tumour Immunology: Alternative Perspectives

1997 • 8 citations

TNFα Interrupts Antigen-Presenting Function of Langerhans Cells by Two Mechanisms: Loss of Immunogenic Peptides and Impairment of Antigen-Independent T Cell Clustering

1995 • 7 citations

Cell interactions and cytokines in transplantation immunity.

1995 • 6 citations