Dendritic cells need T cell help to prime cytotoxic T cell responses to strong antigens

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Introduction of soluble protein into the class I pathway of antigen processing and presentation

1988 • 1,105 citations

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

1995 • 1,097 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.

1996 • 849 citations

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.

1996 • 746 citations

Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

1997 • 729 citations

The JAM test A simple assay for DNA fragmentation and cell death

1991 • 632 citations

Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells.

1996 • 515 citations

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

1982 • 511 citations

Targeted disruption of the MHC class II Aa gene in C57BL/6 mice

1993 • 377 citations

Bone marrow-generated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes.

1995 • 372 citations

Constitutive macropinocytosis allows TAP‐dependent major histocompatibility compex class I presentation of exogenous soluble antigen by bone marrow‐derived dendritic cells

1997 • 351 citations

The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus

1989 • 318 citations

Induction of cytotoxic T-cell responses in vivo in the absence of CD4 helper cells

1987 • 304 citations

CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge

1996 • 287 citations

Genetics of histocompatibility in mice

1975 • 217 citations

Responsiveness to HY Antigen Ir Gene Complementation and Target Cell Specificity

1977 • 215 citations

A fail-safe mechanism for maintaining self-tolerance.

1992 • 213 citations

T4+ T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses

1988 • 205 citations

Dendritic Cells Efficiently Induce Protective Antiviral Immunity

1998 • 189 citations

Three‐cell‐type clusters of T cells with antigen‐presenting cells best explain the epitope linkage and noncognate requirements of the in vivo cytolytic response

1987 • 141 citations

Induction of CD8⁺ cytotoxic T lymphocytes by immunization with syngeneic irradiated HIV-1 envelope derived peptide-pulsed dendritic cells

1993 • 138 citations

Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen.

1979 • 122 citations

Characteristics of the influenza virus-specific CD8+ T cell response in mice homozygous for disruption of the H-2lAb gene.

1995 • 118 citations

Analysis of the role of MHC class II presentation in the stimulation of cytotoxic T lymphocytes by antigens targeted into the exogenous antigen-MHC class I presentation pathway.

1996 • 92 citations

Immunodominance in the T-Cell response to multiple non-H-2 histocompatibility antigens

1986 • 65 citations

Host response to Sendai virus in mice lacking class II major histocompatibility complex glycoproteins

1995 • 65 citations

In vivo induction of antigen-specific transplantation tolerance to Qa1a by exposure to alloantigen in the absence of T-cell help.

1990 • 63 citations

Immunodominance in the immune response to ?multiple? histocompatibility antigens

1982 • 58 citations

ESTIMATES OF THE NUMBER OF LOCI CONTRIBUTING TO THE HISTOINCOMPATIBILITY BETWEEN C57BL/6 AND BALB/c STRAINS OF MICE

1969 • 57 citations

Environmental modulation of the autonomy of cytotoxic T lymphocytes

1993 • 49 citations

Stimulation with dendritic cells decreases or obviates the CD4+ helper cell requirement in cytotoxic T lymphocyte responses

1988 • 46 citations

Ir¹ Genes, Peripheral Cross‐Tolerance and Immunodominance in MHC Class I‐Restricted T‐Cell Responses: An Old Quagmire Revisited

1993 • 15 citations