Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man

1994 • 2,443 citations

Central nervous system control of food intake and body weight

2006 • 2,374 citations

The Emergence of the Metabolic Syndrome with Menopause

2003 • 1,350 citations

Increased adipose tissue in male and female estrogen receptor-α knockout mice

2000 • 1,226 citations

Transcriptional Control of Brown Fat Determination by PRDM16

2007 • 1,085 citations

Regulation of Kiss1 Gene Expression in the Brain of the Female Mouse

2005 • 1,038 citations

Leptin Directly Activates SF1 Neurons in the VMH, and This Action by Leptin Is Required for Normal Body-Weight Homeostasis

2006 • 747 citations

Definition of Estrogen Receptor Pathway Critical for Estrogen Positive Feedback to Gonadotropin-Releasing Hormone Neurons and Fertility

2006 • 561 citations

Gonadal Hormones Determine Sensitivity to Central Leptin and Insulin

2006 • 533 citations

Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurones

1983 • 526 citations

Silencing of estrogen receptor α in the ventromedial nucleus of hypothalamus leads to metabolic syndrome

2007 • 481 citations

The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight

2006 • 479 citations

Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals

2006 • 399 citations

The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus.

1995 • 393 citations

Reduced Energy Expenditure and Increased Inflammation Are Early Events in the Development of Ovariectomy-Induced Obesity

2009 • 387 citations

Characterization of Kiss1 neurons using transgenic mouse models

2010 • 333 citations

Characterization of the Hypothalamic-Pituitary-Gonadal Axis in Estrogen Receptor (ER) Null Mice Reveals Hypergonadism and Endocrine Sex Reversal in Females Lacking ERα But Not ERβ

2003 • 298 citations

Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system

2004 • 291 citations

SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity

2010 • 226 citations

The Role of Kisspeptin–GPR54 Signaling in the Tonic Regulation and Surge Release of Gonadotropin-Releasing Hormone/Luteinizing Hormone

2007 • 221 citations

Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function

2001 • 216 citations

The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus

1995 • 214 citations

Estradiol-17 beta and mu-opioid peptides rapidly hyperpolarize GnRH neurons: a cellular mechanism of negative feedback?

1995 • 196 citations

Identification and characterization of estrogen receptor ?-containing neurons projecting to the vicinity of the gonadotropin-releasing hormone perikarya in the rostral preoptic area of the rat

1999 • 178 citations

Identification of Body Fat Mass as a Major Determinant of Metabolic Rate in Mice

2010 • 162 citations

Association of polymorphisms in the estrogen receptor α gene with body fat distribution

2003 • 151 citations

Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice

2011 • 149 citations

Enhanced Leptin-Stimulated Pi3k Activation in the CNS Promotes White Adipose Tissue Transdifferentiation

2007 • 132 citations

Impact of visceral adipose tissue on liver metabolism

2008 • 130 citations

Leptin receptors in estrogen receptor-containing neurons of the female rat hypothalamus

1998 • 108 citations

PI3K Signaling in the Ventromedial Hypothalamic Nucleus Is Required for Normal Energy Homeostasis

2010 • 107 citations

The potency of mu-opioid hyperpolarization of hypothalamic arcuate neurons is rapidly attenuated by 17 beta-estradiol

1994 • 104 citations

Estradiol Enhances Cholecystokinin-Dependent Lipid-Induced Satiation and Activates Estrogen Receptor-α-Expressing Cells in the Nucleus Tractus Solitarius of Ovariectomized Rats

2007 • 99 citations

Impaired Estrogen Feedback and Infertility in Female Mice with Pituitary-Specific Deletion of Estrogen Receptor Alpha (ESR1)1

2009 • 92 citations

PI3K signaling effects in hypothalamic neurons mediated by estrogen

2007 • 82 citations

Obesity and the Neuroendocrine Control of Energy Homeostasis: The Role of Spontaneous Locomotor Activity

2005 • 68 citations

Hormone Replacement Therapy and Stroke

2008 • 58 citations

Melanocortins Mimic the Effects of Leptin to Restore Reproductive Function in Lean Hypogonadotropic Ewes

2009 • 57 citations

The benefits of oestrogen following menopause: why hormone replacement therapy should be offered to postmenopausal women

2009 • 43 citations

Leptin receptor 5′untranslated regions in the rat: relative abundance, genomic organization and relation to putative response elements

2001 • 42 citations

CNS-Specific Ablation of Steroidogenic Factor 1 Results in Impaired Female Reproductive Function

2010 • 40 citations

Ventromedial hypothalamic stimulation accelerates norepinephrine turnover in brown adipose tissue of rats

1987 • 40 citations