The Human Estrogen Receptor-α Is a Ubiquitinated Protein Whose Stability Is Affected Differentially by Agonists, Antagonists, and Selective Estrogen Receptor Modulators

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

1998 • 2,622 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Recognition of the polyubiquitin proteolytic signal

2000 • 1,651 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

A Multiubiquitin Chain Is Confined to Specific Lysine in a Targeted Short-Lived Protein

1989 • 1,463 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

Nuclear receptor coactivators and corepressors.

1996 • 917 citations

Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages.

1981 • 736 citations

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

1997 • 696 citations

Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes

1998 • 667 citations

Coactivator and Corepressor Regulation of the Agonist/Antagonist Activity of the Mixed Antiestrogen, 4-Hydroxytamoxifen

1997 • 640 citations

Proteasome-dependent degradation of the human estrogen receptor

1999 • 573 citations

The 26S Proteasome Is Required for Estrogen Receptor-α and Coactivator Turnover and for Efficient Estrogen Receptor-α Transactivation

2000 • 561 citations

The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling

1993 • 524 citations

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.

1995 • 502 citations

Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex

1990 • 486 citations

Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover.

1992 • 468 citations

The Partial Agonist Activity of Antagonist-Occupied Steroid Receptors Is Controlled by a Novel Hinge Domain-Binding Coactivator L7/SPA and the Corepressors N-CoR or SMRT

1997 • 468 citations

Interaction of thyroid-hormone receptor with a conserved transcriptional mediator

1995 • 429 citations

Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances.

1981 • 424 citations

Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration.

1988 • 417 citations

Estrogen receptor (ER) modulators each induce distinct conformational changes in ER α and ER β

1999 • 405 citations

Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm.

1994 • 395 citations

Peptide Antagonists of the Human Estrogen Receptor

1999 • 372 citations

Dissection of the LXXLL Nuclear Receptor-Coactivator Interaction Motif Using Combinatorial Peptide Libraries: Discovery of Peptide Antagonists of Estrogen Receptors α and β

1999 • 362 citations

Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer

1995 • 351 citations

Proteasome-Mediated Proteolysis of Estrogen Receptor: A Novel Component in Autologous Down-Regulation

1999 • 285 citations

Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).

1988 • 284 citations

Dynamics of proteasome distribution in living cells

1997 • 269 citations

Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis

2000 • 261 citations

Direct Visualization of the Human Estrogen Receptor α Reveals a Role for Ligand in the Nuclear Distribution of the Receptor

1999 • 258 citations

Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain.

1993 • 249 citations

Comparative Analyses of Mechanistic Differences Among Antiestrogens1

1999 • 245 citations

Identification of a New Subclass of Alu DNA Repeats Which Can Function as Estrogen Receptor-dependent Transcriptional Enhancers

1995 • 226 citations

Proteasomal regulation of nuclear receptor corepressor-mediated repression

1998 • 225 citations

A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line.

1994 • 225 citations

Proteasome-mediated degradation of transcriptional activators correlates with activation domain potency in vivo

1999 • 190 citations

Ubc9 Interacts with the Androgen Receptor and Activates Receptor-dependent Transcription

1999 • 181 citations

Molecular Determinants of the Estrogen Receptor-Coactivator Interface

1999 • 167 citations

Yeast RSP5 and Its Human Homolog hRPF1 Potentiate Hormone-Dependent Activation of Transcription by Human Progesterone and Glucocorticoid Receptors

1996 • 160 citations

Estradiol increases and anti-estrogens antagonize the growth factor-induced activator protein-1 activity in MCF7 breast cancer cells without affecting c-fos and c-jun synthesis

1993 • 159 citations

Estrogen Receptor Synthesis and Turnover in MCF-7 Breast Cancer Cells Measured by a Density Shift Technique*

1984 • 142 citations

Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity.

1996 • 139 citations

Implication of proteasome in estrogen receptor degradation

1999 • 137 citations

A uniform isopeptide-linked multiubiquitin chain is sufficient to target substrate for degradation in ubiquitin-mediated proteolysis.

1990 • 136 citations

Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor.

2001 • 130 citations

Antiestrogens: Mechanisms and actions in target cells

1995 • 110 citations

Enhancement of Estrogen Receptor Transcriptional Activity by the Coactivator GRIP-1 Highlights the Role of Activation Function 2 in Determining Estrogen Receptor Pharmacology

1998 • 99 citations

Characterization of the Estrogen Receptor and Its Dynamics in MCF-7 Human Breast Cancer Cells Using a Covalently Attaching Antiestrogen*

1984 • 98 citations

Novel estrogen response elements identified by genetic selection in yeast are differentially responsive to estrogens and antiestrogens in mammalian cells.

1994 • 92 citations

Dynamics of Estrogen Receptor Turnover in Uterine Cellsin Vitroand in Uteriin Vivo*

1986 • 83 citations

Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity [published erratum appears in Mol Endocrinol 1997 Mar;11(3):341]

1996 • 60 citations

The Estrogen Receptor in MCF-7 Cells: Evidence from Dense Amino Acid Labeling for Rapid Turnover and a Dimeric Model of Activated Nuclear Receptor

1984 • 37 citations