Implication of proteasome in estrogen receptor degradation

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue

1986 • 1,942 citations

Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor

1987 • 1,920 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

How Proteolysis Drives the Cell Cycle

1996 • 1,277 citations

Calcium-activated neutral protease (calpain) system: structure, function, and regulation.

1991 • 841 citations

Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptor.

1978 • 797 citations

Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination

1992 • 780 citations

Mitosis in transition

1994 • 745 citations

Peptide sequences that target cytosolic proteins for lysosomal proteolysis

1990 • 674 citations

In vivo ubiquitination and proteasome-mediated degradation of p53(1).

1996 • 643 citations

THE UBIQUITIN-CONJUGATION SYSTEM

1992 • 561 citations

Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins

1995 • 492 citations

The multicatalytic proteinase complex, a major extralysosomal proteolytic system

1990 • 464 citations

Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens.

1987 • 413 citations

Proteasomes: multicatalytic proteinase complexes

1993 • 395 citations

ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.

1989 • 370 citations

The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins.

1990 • 327 citations

An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.

1996 • 274 citations

Calmodulin-binding proteins as calpain substrates

1989 • 274 citations

Breast Cancer

1992 • 249 citations

Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2.

1994 • 235 citations

Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown.

1984 • 232 citations

Degradation of transcription factors, c‐Jun and c‐Fos, by calpain

1991 • 163 citations

Construction of Cell Lines that Express High Levels of the Human Estrogen Receptor and Are Killed by Estrogens

1990 • 152 citations

Estradiol-induced Down-regulation of estrogen receptor. Effect of various modulators of protein synthesis and expression

1994 • 120 citations

Specific cleavage of transcription factors by the thiol protease, m-calpain

1993 • 99 citations

Isolation and characterization of an enkephalin-degrading aminopeptidase from rat brain

1979 • 95 citations

Dynamics of Estrogen Receptor Turnover in Uterine Cellsin Vitroand in Uteriin Vivo*

1986 • 83 citations

Cellular Proteolysis An Overview

1992 • 75 citations

Specific Inhibitors of Vacuolar H+-ATPase Trigger Apoptotic Cell Death of Osteoclasts

1997 • 70 citations

An assessment of the role of domain F and pest sequences in estrogen receptor half-life and bioactivity

1993 • 52 citations

Estrogenic and antiestrogenic regulation of the half-life of covalently labeled estrogen receptor in MCF-7 breast cancer cells

1996 • 51 citations

Characterization of a functional domain of human calpastatin

1990 • 49 citations

Oxidation-induced lymphocyte transformation

1976 • 48 citations

Inhibition of basal protein degradation in rat embryo fibroblasts by cycloheximide: Correlation with activities of lysosomal proteases

1978 • 43 citations

The Estrogen Receptor in MCF-7 Cells: Evidence from Dense Amino Acid Labeling for Rapid Turnover and a Dimeric Model of Activated Nuclear Receptor

1984 • 37 citations

Estrogenic and anti-estrogenic regulation of estrogen receptor in MCF-7 breast-cancer cells: Comparison of immunocytochemical data with biochemical measurements

1998 • 36 citations

Proteasome location

1993 • 33 citations

Ca2+-dependent neutral protease (Calpain) activity in breast cancer tissue and estrogen receptor status

1996 • 32 citations

Extracellular factors, signalling pathways and differentiation of adipose precursor cells

1990 • 32 citations

Action of Calpain on the Basic Estrogen Receptor Molecule of Porcine Uterus1

1984 • 30 citations

Eukaryotic protein degradation

1990 • 30 citations

Lactacystin, an Inhibitor of the Proteasome, Blocks the Degradation of a Mutant Precursor of Glycosylphosphatidylinositol-Linked Protein in a Pre-Golgi Compartment

1996 • 30 citations

Significant Amount of Multicatalytic Proteinase Identified on Membrane from Human Erythrocyte1

1990 • 25 citations

Protein synthesis is not implicated in the ligand-dependent activation of the estrogen receptor in MCF-7 cells

1997 • 22 citations

220 Reproductive factors and the natural history of cervical cancer

1983 • 3 citations