A Phase I/II Evaluation of Oral L‐2‐Oxothiazolidine‐4‐Carboxylic Acid in Asymptomatic Patients Infected with Human Immunodeficiency Virus

GLUTATHIONE

1983 • 5,487 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

SYSTEMIC GLUTATHIONE DEFICIENCY IN SYMPTOM-FREE HIV-SEROPOSITIVE INDIVIDUALS

1989 • 725 citations

The Regulation of Hepatic Glutathione

1985 • 615 citations

Critical evaluation of the potential error in pharmacokinetic studies of using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve

1978 • 613 citations

Glutathione metabolism and its role in hepatotoxicity

1991 • 495 citations

Analysis of biological thiols: Derivatization with monobromobimane and separation by reverse-phase high-performance liquid chromatography

1981 • 451 citations

Low Concentrations of Acid-Soluble Thiol (Cysteine) in the Blood Plasma of HIV-1-Infected Patients

1989 • 349 citations

Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesis.

1982 • 286 citations

Membrane Expression of HIV Envelope Glycoproteins Triggers Apoptosis in CD4 Cells

1993 • 210 citations

Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxo-L-prolinase substrate.

1981 • 199 citations

Analysis of biological thiols: Quantitative determination of thiols at the picomole level based upon derivatization with monobromobimanes and separation by cation-exchange chromatography

1981 • 198 citations

Intracellular cysteine and glutathione delivery systems.

1986 • 195 citations

Intracellular Glutathione Levels in T Cell Subsets Decrease in HIV-Infected Individuals

1992 • 161 citations

Adverse reactions to co-trimoxazole in HIV infection

1991 • 155 citations

CD4 and CD8 T cells with high intracellular glutathione levels are selectively lost as the HIV infection progresses

1991 • 145 citations

Increased Production of Malondialdehyde in Patients with HIV Infection

1988 • 123 citations

Enhancement of intracellular glutathione promotes lymphocyte activation by mitogen

1986 • 76 citations

L-2-oxothiazolidine-4-carboxylic acid, a cysteine prodrug: pharmacokinetics and effects on thiols in plasma and lymphocytes in human.

1991 • 74 citations

Increased Phagocytosis and Generation of Reactive Oxygen Products by Neutrophils and Monocytes of Men with Stage 1 Human Immunodeficiency Virus Infection

1993 • 68 citations

Renal and hepatic output of glutathione in plasma and whole blood

1992 • 55 citations

Transport accounts for glutathione turnover in human erythrocytes

1979 • 55 citations

Glutathione and γ-glutamylcysteine in whole blood, plasma and erythrocytes

1978 • 54 citations

A phase I/II trial of intravenous L-2-oxothiazolidine-4-carboxylic acid (procysteine) in asymptomatic HIV-infected subjects.

1994 • 29 citations

Glutathione and Immunophenotypes of T and B Lymphocytes in HIV‐Infected Individuals^a

1992 • 24 citations

Toxicity evaluations of l-cysteine and Procysteine™, a cysteine prodrug, given once intravenously to neonatal rats

1993 • 17 citations

Simultaneous measurement of neutrophil, lymphocyte, and monocyte glutathione by flow cytometry

1990 • 17 citations

Protection by L-2-oxothiazolidine-4-carboxylate, a cysteine prodrug, against 1,1-dichloroethylene hepatotoxicity in rats is associated with decreases in toxin metabolism and cytochrome P-450.

1989 • 15 citations

The effect of changes in thiol subcompartments on T-cell colony formation and cell cycle progression: Relevance to AIDS

1992 • 14 citations

In Vivo Regulation of Hepatic Glutathione Synthesis: Effects of Food Deprivation or Glutathione Depletion by Electrophilic Compounds

1982 • 10 citations

Determination of l-2-oxothiazolidine-4-carboxylic acid (Procysteine®) in human plasma by high-performance liquid chromatography

1994 • 2 citations