Myocardial ischemia, reperfusion and free radical injury

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Inflammation. Basic principles and clinical correlates

1989 • 2,424 citations

The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs.

1977 • 1,927 citations

Identification of an inducible endothelial-leukocyte adhesion molecule.

1987 • 1,639 citations

Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog.

1983 • 1,168 citations

Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

1984 • 915 citations

Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion.

1988 • 650 citations

Recognition of an endothelial determinant for CD 18-dependent human neutrophil adherence and transendothelial migration.

1988 • 626 citations

Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.

1988 • 610 citations

Warner-Lambert/Parke-Davis award lecture. Cytokine-mediated activation of vascular endothelium. Physiology and pathology.

1988 • 597 citations

Molecular oxygen: Friend and foe*The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury

1984 • 543 citations

A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo

1987 • 525 citations

Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs.

1984 • 468 citations

THE PHLOGISTIC ROLE OF C3 LEUKOTACTIC FRAGMENTS IN MYOCARDIAL INFARCTS OF RATS

1971 • 388 citations

Free Radicals in Medicine. II. Involvement in Human Disease

1988 • 344 citations

Enhancement of recovery of myocardial function by oxygen free-radical scavengers after reversible regional ischemia.

1985 • 324 citations

Leukocytes and Ischemia-Induced Myocardial Injury

1986 • 321 citations

Mechanism of neutrophil activation by NAF, a novel monocyte‐derived peptide agonist

1988 • 320 citations

Factors involved in salvaging ischemic myocardium: effect of reperfusion of arterial blood.

1983 • 318 citations

Inflammation: Basic Principles and Clinical Correlates

1988 • 275 citations

Does captopril attenuate reperfusion-induced myocardial dysfunction by scavenging free radicals?

1988 • 229 citations

EXPERIMENTAL ACUTE MYOCARDIAL INFARCTION; HISTOLOGIC AND HISTOCHEMICAL STUDIES OF EARLY MYOCARDIAL INFARCTS INDUCED BY TEMPORARY OR PERMANENT OCCLUSION OF A CORONARY ARTERY.

1964 • 223 citations

Ultrastructural damage associated with reoxygenation of the anoxic myocardium

1975 • 202 citations

The effect of ibuprofen on accumulation of indium-111-labeled platelets and leukocytes in experimental myocardial infarction.

1982 • 199 citations

Failure of superoxide dismutase to limit size of myocardial infarction after 40 minutes of ischemia and 4 days of reperfusion in dogs.

1987 • 199 citations

Iloprost inhibits neutrophil function in vitro and in vivo and limits experimental infarct size in canine heart.

1987 • 197 citations

Reduction of the size of infarction by allopurinol in the ischemic-reperfused canine heart.

1986 • 193 citations

Failure of the xanthine oxidase inhibitor allopurinol to limit infarct size after ischemia and reperfusion in dogs.

1985 • 180 citations

Complement and neutrophil activation in the pathogenesis of ischemic myocardial injury.

1988 • 171 citations

Relative contribution of the leukocyte molecules MO1, LFA‐1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue‐ and stimulus‐specific

1988 • 162 citations

Prostacyclin protects ischemic reperfused myocardium in the dog by inhibition of neutrophil activation

1987 • 159 citations

Mechanism of complement activation after coronary artery occlusion: evidence that myocardial ischemia in dogs causes release of constituents of myocardial subcellular origin that complex with human C1q in vivo.

1988 • 154 citations

Superoxide dismutase conjugated to polyethylene glycol provides sustained protection against myocardial ischemia/reperfusion injury in canine heart.

1988 • 126 citations

Effect of indomethacin on collateral blood flow and infarct size in the conscious dog.

1979 • 118 citations

N-2-Mercaptopropionylglycine improves recovery of myocardial function after reversible regional ischemia

1986 • 115 citations

C3 LEUKOTACTIC FACTORS PRODUCED BY A TISSUE PROTEASE

1969 • 114 citations

Monokine-induced gene expression of a human endothelial cell-derived neutrophil chemotactic factor

1988 • 112 citations

Salvage of ischemic myocardium by ibuprofen during infarction in the conscious dog

1980 • 112 citations

Identification of a time window for therapy to reduce experimental canine myocardial injury: suppression of neutrophil activation during 72 hours of reperfusion.

1988 • 107 citations

Canine myocardial reperfusion injury: protection by a free radical scavenger, N-2-mercaptopropionyl glycine.

1986 • 95 citations

Prevention of pulmonary injury in isolated perfused rat lungs by activated human neutrophils preincubated with anti-Mo1 monoclonal antibody.

1987 • 93 citations

Physiology and Pathology

1978 • 88 citations

Leukocytes, oxygen radicals, and myocardial injury due to ischemia and reperfusion

1988 • 84 citations

Canine Myocardial Reperfusion Injury

1986 • 78 citations

Ibuprofen inhibits granulocyte responses to inflammatory mediators

1984 • 71 citations

Reduction of experimental canine myocardial infarct size with prostaglandin E1: inhibition of neutrophil migration and activation.

1988 • 64 citations

On the Specificity of Allopurinol and Oxypurinol as Inhibitors of Xanthine Oxidase. A Pulse Radiolysis Determination of Rate Constants for Reaction of Allopurinol and Oxypurinol with Hydroxyl Radicals

1988 • 59 citations

Myocardial ischemia and reperfusion: The role of oxygen radicals in tissue injury

1989 • 57 citations

A nonflow basis for the vulnerability of the subendocardium

1987 • 28 citations

Effects ofd-penicillamine on a model of oxygen-derived free radical mediated tissue damage

1984 • 22 citations

Advances in Thrombolytic Therapy for Acute Myocardial Infarction

1987 • 17 citations

Chemical radiation protection by alpha-mercaptopropionylglycine.

1983 • 16 citations