Advances in Thrombolytic Therapy for Acute Myocardial Infarction

The thrombolysis in myocardial infarction (TIMI) trial. Phase I findings

1985 • 3,610 citations

The Thrombolysis in Myocardial Infarction (TIMI) Trial

1985 • 3,078 citations

Prevalence of Total Coronary Occlusion during the Early Hours of Transmural Myocardial Infarction

1980 • 2,722 citations

EFFECTIVENESS OF INTRAVENOUS THROMBOLYTIC TREATMENT IN ACUTE MYOCARDIAL INFARCTION

1986 • 2,315 citations

Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge.

1987 • 2,245 citations

A Randomized Trial of Immediate versus Delayed Elective Angioplasty after Intravenous Tissue Plasminogen Activator in Acute Myocardial Infarction

1987 • 964 citations

CLINICAL FEATURES OF SUDDEN OBSTRUCTION OF THE CORONARY ARTERIES

1912 • 893 citations

Selective intracoronary thrombolysis in acute myocardial infarction and unstable angina pectoris.

1981 • 811 citations

Western Washington Randomized Trial of Intracoronary Streptokinase in Acute Myocardial Infarction

1983 • 805 citations

RANDOMISED TRIAL OF INTRAVENOUS RECOMBINANT TISSUE-TYPE PLASMINOGEN ACTIVATOR VERSUS INTRAVENOUS STREPTOKINASE IN ACUTE MYOCARDIAL INFARCTION

1985 • 756 citations

Thrombolysis inMyocardial Infarction (TIMI) Trial, Phase I:acomparison between intravenous tissue plasminogen activator andintravenous streptokinase*

1987 • 751 citations

A Prospective Trial of Intravenous Streptokinase in Acute Myocardial Infarction (I.S.A.M.)

1986 • 705 citations

THE FIBRINOLYTIC ACTIVITY OF HEMOLYTIC STREPTOCOCCI

1933 • 617 citations

Intracoronary thrombolysis in evolving myocardial infarction

1981 • 594 citations

Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: Overview of results on mortality, reinfarction and side-effects from 33 randomized controlled trials

1985 • 578 citations

A Randomized Trial of Intracoronary Streptokinase in the Treatment of Acute Myocardial Infarction

1983 • 536 citations

A Prospective Randomized Clinical Trial of Intracoronary Streptokinase versus Coronary Angioplasty for Acute Myocardial Infarction

1986 • 510 citations

Selective intracoronary thrombolysis in acute myocardial infarction and unstable angina pectoris.

1981 • 459 citations

IMPROVED SURVIVAL AFTER EARLY THROMBOLYSIS IN ACUTE MYOCARDIAL INFARCTION

1985 • 450 citations

Coronary thrombolysis with recombinant human tissue-type plasminogen activator: a prospective, randomized, placebo-controlled trial.

1984 • 387 citations

Intracoronary Fibrinolytic Therapy in Acute Myocardial Infarction

1983 • 385 citations

THE EFFECT IN PATIENTS OF STREPTOCOCCAL FIBRINOLYSIN (STREPTOKINASE) AND STREPTOCOCCAL DESOXYRIBONUCLEASE ON FIBRINOUS, PURULENT, AND SANGUINOUS PLEURAL EXUDATIONS 1

1949 • 377 citations

Intravenous short-term infusion of streptokinase in acute myocardial infarction.

1983 • 368 citations

A Randomized Trial of Intravenous Tissue Plasminogen Activator for Acute Myocardial Infarction with Subsequent Randomization to Elective Coronary Angioplasty

1987 • 362 citations

Preservation of global and regional left ventricular function after early thrombolysis in acute myocardial infarction

1986 • 328 citations

Acute coronary reocclusion after thrombolysis with recombinant human tissue-type plasminogen activator: prevention by a maintenance infusion.

1986 • 302 citations

Streptokinase in Acute Myocardial Infarction

1979 • 296 citations

Free radicals and myocardial injury: pharmacologic implications.

1986 • 294 citations

Intravenous recombinant tissue-type plasminogen activator in patients with acute myocardial infarction: a report from the NHLBI thrombolysis in myocardial infarction trial.

1986 • 291 citations

Effects of Intracoronary Streptokinase and Intracoronary Nitroglycerin Infusion on Coronary Angiographic Patterns and Mortality in Patients with Acute Myocardial Infarction

1984 • 288 citations

DOUBLE-BLIND RANDOMISED TRIAL OF INTRAVENOUS TISSUE-TYPE PLASMINOGEN ACTIVATOR VERSUS PLACEBO IN ACUTE MYOCARDIAL INFARCTION

1985 • 242 citations

Effect of Intravenous Streptokinase on Acute Myocardial Infarction

1982 • 206 citations

Randomized trial of intravenous recombinant tissue-type plasminogen activator versus intravenous streptokinase in acute myocardial infarction

1985 • 202 citations

Failure of superoxide dismutase to limit size of myocardial infarction after 40 minutes of ischemia and 4 days of reperfusion in dogs.

1987 • 199 citations

[Intracoronary administration of fibrinolysin in acute myocardial infarct].

1976 • 189 citations

Intravenous urokinase in acute myocardial infarction

1985 • 186 citations

A multicenter, randomized, placebo-controlled trial of a new form of intravenous recombinant tissue-type plasminogen activator (activase) in acute myocardial infarction

1987 • 186 citations

A randomized, angiographically controlled trial of intracoronary streptokinase in acute myocardial infarction

1984 • 183 citations

Initial experience with transluminal recanalization of the recently occluded infarct‐related coronary artery in acute myocardial infarction — Comparison with conventionally treated patients

1979 • 179 citations

Time from onset of symptoms to thrombolytic therapy: A major determinant of myocardial salvage in patients with acute transmural infarction

1985 • 167 citations

Thrombolytic therapy in patients with acute myocardial infarction.

1985 • 160 citations

Acute myocardial infarction treated with intracoronary streptokinase: A report of the society for cardiac angiography

1985 • 160 citations

Tissue-Type Plasminogen Activator

1989 • 159 citations

Coronary thrombolysis by intravenous streptokinase in acute myocardial infarction: Acute and follow-up studies

1984 • 155 citations

Analysis of coagulation and fibrinolysis during intravenous infusion of recombinant human tissue-type plasminogen activator in patients with acute myocardial infarction.

1986 • 154 citations

Efforts to Limit the Size of Myocardial Infarcts

1981 • 152 citations

The treatment of patients suffering from early myocardial infarction with massive and prolonged streptokinase therapy.

1958 • 152 citations

Multicenter reperfusion trial of intravenous anisoylated plasminogen streptokinase activator complex (APSAC) in acute myocardial infarction: Controlled comparison with intracoronary streptokinase

1988 • 145 citations

Coronary thrombolysis with recombinant single-chain urokinase-type plasminogen activator in patients with acute myocardial infarction.

1986 • 126 citations

Synergism of thrombolytic agents in vivo.

1986 • 116 citations

Prevention of Myocardial Infarction by Very Early Treatment with Intracoronary Streptokinase

1984 • 112 citations

Comparative properties of two clinical preparations of recombinant human tissue-type plasminogen activator in patients with acute myocardial infarction

1987 • 109 citations

Coronary Thrombolysis with Human Single-Chain, Urokinase-Type Plasminogen Activator (Pro-Urokinase) in Patients with Acute Myocardial Infarction

1986 • 108 citations

Coronary Thrombolysis with Recombinant Tissue-Type Plasminogen Activator

1985 • 96 citations

Thrombolysis, clot selectivity, and kinetics.

1984 • 92 citations

Rapid Lysis of Coronary Artery Thrombi with Anisoylated Plasminogen: Streptokinase Activator Complex

1986 • 91 citations

Coronary thrombolysis in patients with acute myocardial infarction by intravenous infusion of synergic thrombolytic agents

1986 • 90 citations

Intracoronary thrombolytic therapy in acute myocardial infarction: A prospective, randomized, controlled trial

1985 • 86 citations

Clinical effects and kinetic properties of intravenous APSAC — anisoylated plasminogen-streptokinase activator complex (BRL 26921) in acute myocardial infarction

1986 • 81 citations

Coronary anatomy and left ventricular function in the first 12 hours of acute myocardial infarction: the Western Washington Randomized Intracoronary Streptokinase Trial.

1985 • 71 citations

Hemorrheologic changes following acute myocardial infarction

1982 • 66 citations

Recombinant tissue plasminogen activator (rt-PA): Is it the thrombolytic agent of choice for an evolving acute myocardial infarction?

1987 • 61 citations

Intracoronary thrombolysis with an acylated streptokinase-plasminogen activator (BRL 26921) in patients with acute myocardial infarction

1984 • 61 citations

High dose intravenous streptokinase for acute myocardial infarction: preliminary results of a multicenter trial

1985 • 58 citations

Relation of effectiveness of intracoronary thrombolysis in acute myocardial infarction to systemic thrombolytic state

1985 • 55 citations

Relationship of the lytic state to successful reperfusion with standard- and low-dose intracoronary streptokinase.

1985 • 54 citations

Tissue Plasminogen Activator (t-PA)

1985 • 53 citations

Thrombolysis by a fibrin-specific antibody fab′-urokinase conjugate

1987 • 46 citations

Acylated Streptokinase – Plasminogen Complex in Patients with Acute Myocardial Infarction

1984 • 42 citations

Intracoronary fibrinolytic therapy in acute myocardial infarction — report of a prospective randomized trial

1984 • 33 citations

Beneficial effects of tissue-type plasminogen activator in acute myocardial ischemia in cats

1986 • 32 citations

A randomized trial of intravenous tissue plasminogen activator for acute myocardial infarction with subsequent randomization to elective coronary angioplasty

1988 • 22 citations

Beneficial Effects of Streptokinase on Left Ventricular Function After Myocardial Reoxygenation and Reperfusion Following Global Ischemia in the Isolated Rabbit Heart

1984 • 12 citations

Improved left ventricular function and early survival with intravenous streptokinase a double blind trial

1986 • 6 citations

Acute Coronary Intervention

1988 • 5 citations

FDA Puts New Heart Drug on Hold

1987 • 5 citations