Internalization and intracellular processing of insulin and insulin receptors in adipocytes

Metabolism of Isolated Fat Cells

1964 • 4,431 citations

The Metabolism of Isolated Fat Cells: I. Effects of Hormones on Glucose Metabolism and Lipolysis

1964 • 1,401 citations

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

Methods for the determination of adipose cell size in man and animals

1968 • 896 citations

Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects.

1980 • 665 citations

The Significance of Basal Insulin Levels in the Evaluation of the Insulin Response to Glucose in Diabetic and Nondiabetic Subjects*

1967 • 664 citations

Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells

1978 • 647 citations

Monoiodoinsulin: Demonstration of its biological activity and binding to fat cells and liver membranes

1971 • 521 citations

Binding and degradation of 125I-insulin by rat hepatocytes.

1975 • 419 citations

Insulin-Receptor Interaction in the Obese-Hyperglycemic Mouse

1973 • 408 citations

The subunit structure of the high affinity insulin receptor. Evidence for a disulfide-linked receptor complex in fat cell and liver plasma membranes.

1980 • 388 citations

Binding and degradation of 125I-labelled insulin by isolated rat fat cells

1973 • 339 citations

Insulin receptor: covalent labeling and identification of subunits.

1979 • 243 citations

Binding and uptake of 125I-insulin into rat liver hepatocytes and endothelium. An in vivo radioautographic study.

1979 • 223 citations

Intracellular Translocation of Iodine-125-Labeled Insulin: Direct Demonstration in Isolated Hepatocytes

1978 • 220 citations

Insulin Binding in Diabetes: Relationships with Plasma Insulin Levels and Insulin Sensitivity

1977 • 202 citations

On the mechanism of ligand-induced down-regulation of insulin receptor level in the liver cell.

1981 • 198 citations

Photoaffinity labeling of insulin receptor proteins of liver plasma membrane preparations

1980 • 195 citations

Purification of the insulin receptor from human placenta by chromatography on immobilized wheat germ lectin and receptor antibody.

1980 • 187 citations

Effects of lysosomotropic agents on insulin interactions with adipocytes. Evidence for a lysosomal pathway for insulin processing and degradation.

1979 • 185 citations

Down Regulation of Insulin Receptors in Primary Cultures of Adult Rat Hepatocytes in Monolayer*

1978 • 178 citations

Effects of insulin incubation on insulin binding, glucose transport, and insulin degradation by isolated rat adipocytes. Evidence for hormone-induced desensitization at the receptor and postreceptor level.

1980 • 168 citations

Evidence for recycling of insulin receptors in isolated rat adipocytes.

1981 • 165 citations

Internalization and degradation of fat cell-bound insulin. Separation and partial characterization of subcellular vesicles associated with iodoinsulin.

1979 • 161 citations

Purification and properties of the human placental insulin receptor.

1981 • 161 citations

Insulin binding to liver plasm membranes in the obese hyperglycemic (ob/ob) mouse. Demonstration of a decreased number of functionally normal receptors.

1975 • 152 citations

Surface binding and rates of internalization of 125I-insulin in adipocytes and IM-9 lymphocytes.

1982 • 116 citations

Uptake of insulin by plasmalemma and Golgi subcellular fractions of rat liver.

1980 • 116 citations

Evidence for insulin-induced internalization and degradation of insulin receptors in rat adipocytes.

1982 • 105 citations

Photoreactive insulin analogues used to characterise the insulin receptor

1980 • 101 citations

Lysosomal Degradation of Receptor-bound 125I-labeled Insulin by Rat Adipocytes: Its Characterization and Dissociation from the Short-term Biologic Effects of Insulin

1980 • 96 citations

Stoichiometric binding and regulation of insulin receptors on human diploid fibroblasts using physiologic insulin levels.

1979 • 93 citations

Effect of experimental hyperinsulinemia on insulin binding and glucose transport in isolated rat adipocytes.

1978 • 93 citations

Insulin-dependent regulation of the insulin-sensitivity of adipocytes

1978 • 86 citations

Insulin Degradation by Hepatocytes in Primary Culture*

1981 • 78 citations

Insulin receptors of cultured human lymphocytes (IM-9). Lack of receptor-mediated degradation.

1980 • 67 citations

Interactions Between Insulin and Its Receptors After the Initial Binding Event: Functional Heterogeneity and Relationships to Insulin Degradation

1979 • 66 citations

The Endocytotic-Internalization Pathway of Insulin Metabolism: Relationship to Insulin Degradation and Activation of Glucose Transport*

1980 • 63 citations

Receptor‐mediated internalisation of insulin in intact rat liver

1979 • 57 citations

Insulin degradation by insulin target cells

1981 • 56 citations

Sequential Degradation of Insulin by Rat Liver Homogenates

1972 • 56 citations

Insulin Degradation by Liver Cell Membranes*

1979 • 53 citations

Characterization of Insulin-induced Receptor Loss and Evidence for Internalization of the Insulin Receptor

1981 • 52 citations

Photoaffinity Labeling of Insulin Receptors in Viable Cultured Human Lymphocytes: Demonstration of Receptor Shedding and Degradation

1982 • 47 citations

An Evaluation of the Importance of Lysosomal and Neutral Cytosol Proteases in Insulin Degradation by Adipocytes*

1981 • 42 citations

Insulin degradation: XVI. Evidence for the Sequential Degradative Pathway in Isolated Liver Cells

1976 • 34 citations

Tris(hydroxmethyl)aminomethane permits the expression of insulin-induced receptor loss in isolated rat adipocytes

1981 • 32 citations

Binding and Degradation of Semisynthetic Tritiated Insulin by IM-9 Cultured Human Lymphocytes

1980 • 31 citations

Insulin binding, internalization, and receptor regulation in cultured human fibroblasts

1981 • 31 citations

Rapid down regulation of insulin receptors in adipocytes artifact of the incubation buffer

1981 • 29 citations

[(125I]IodotyrosylB1]insulin. Semisynthesis, receptor binding, and cell-mediated degradation of a B chain-labeled insulin.

1981 • 27 citations

Insulin degradation by adipose tissue. Studies at several levels of cellular organization

1980 • 25 citations

Lysosomal degradation of receptor-bound 125I-labeled insulin by rat adipocytes: its characterization and dissociation from the short-term biologic effects of insulin

1980 • 23 citations

Regulation of Insulin Receptors in Cultured Human Fibroblasts*

1981 • 18 citations

Binding and degradation of semisynthetic tritiated insulin by IM-9 cultured human lymphocytes

1980 • 14 citations

Insulin degradation. XVI. Evidence for the sequential degradative pathway in isolated liver cells

1976 • 12 citations