Low frequency ofp16/CDKN2 gene mutations in esophageal carcinomas

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

1994 • 1,142 citations

Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.

1993 • 367 citations

Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma.

1994 • 345 citations

p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma.

1994 • 324 citations

Genetic alterations in esophageal cancer and their relevance to etiology and pathogenesis: A review

1996 • 299 citations

Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck.

1994 • 237 citations

Rarity of somatic and germline mutations of the cyclin-dependent kinase 4 inhibitor gene, CDK4I, in melanoma.

1994 • 176 citations

Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers.

1995 • 158 citations

The MTS1 gene is frequently mutated in primary human esophageal tumors.

1994 • 112 citations

Mutational analysis of CDKN2 (MTS1/p16ink4) in human breast carcinomas.

1994 • 107 citations

MTS1/CDKN2 gene mutations are rare in primary human astrocytomas with allelic loss of chromosome 9p

1994 • 95 citations

Mutation frequency of the p16/CDKN2 gene in primary cancers in the upper digestive tract.

1995 • 81 citations

Frequent loss of heterozygosity on chromosome 9 in adenocarcinoma and squamous cell carcinoma of the esophagus.

1994 • 68 citations

Highly Frequent Homozygous Deletion of the p16 Gene in Esophageal Cancer Cell Lines

1994 • 67 citations

Frequent loss of heterozygosity on chromosome 9, and low incidence of mutations of cyclin-dependent kinase inhibitors p15 (MTS2) and p16 (MTS1) genes in gliomas.

1995 • 53 citations

Correlation of p53 mutations with epidermal growth factor receptor overexpression and absence of mdm2 amplification in human esophageal carcinomas

1993 • 40 citations

p16 INK4 Mutations and Altered Expression in Human Tumors and Cell Lines

1994 • 32 citations