IL-27 regulates IL-12 responsiveness of naïve CD4 ⁺ T cells through Stat1-dependent and -independent mechanisms

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

The lineage decisions of helper T cells

2002 • 1,678 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells

2002 • 1,401 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

Cytokine Signaling in 2002

2002 • 1,089 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

2002 • 985 citations

Role of T-bet in Commitment of T _H 1 Cells Before IL-12-Dependent Selection

2001 • 813 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

1997 • 783 citations

T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells

2001 • 743 citations

The Stat family in cytokine signaling

2001 • 723 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene

1997 • 666 citations

Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment

2003 • 534 citations

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.

1996 • 529 citations

WSX-1 Is Required for the Initiation of Th1 Responses and Resistance to L. major Infection

2001 • 409 citations

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

2000 • 394 citations

The biology of Stat4 and Stat6

2000 • 310 citations

GATA-3 Suppresses Th1 Development by Downregulation of Stat4 and Not through Effects on IL-12Rβ2 Chain or T-bet

2003 • 266 citations

IL-21 Up-Regulates the Expression of Genes Associated with Innate Immunity and Th1 Response

2002 • 248 citations

Cloning and Characterization of a Novel Class I Cytokine Receptor

1998 • 140 citations