The two intervening sequences of human beta- and gamma-globin pre-mRNAs are excised in a preferred temporal order in vitro.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

Mapping of RNA by a modification of the Berk-Sharp procedure: the 5′ termini of 15 S β-globin mRNA precursor and mature 10 S β-globin mRNA have identical map coordinates

1979 • 1,286 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

Specific transcription and RNA splicing defects in five cloned β-thalassaemia genes

1983 • 627 citations

Human β-globin pre-mRNA synthesized in vitro is accurately spliced in xenopus oocyte nuclei

1983 • 500 citations

Lariat RNA's as Intermediates and Products in the Splicing of Messenger RNA precursors

1984 • 474 citations

A single-base change at a splice site in a β0-thalassemic gene causes abnormal RNA splicing

1982 • 372 citations

Abnormal RNA processing due to the exon mutation of βE-globin gene

1982 • 309 citations

β+ Thalassemia: Aberrant splicing results from a single point mutation in an intron

1981 • 235 citations

In vivo splicing products of the rabbit β-globin pre-mRNA

1984 • 209 citations

beta-Thalassemia in American Blacks: novel mutations in the "TATA" box and an acceptor splice site.

1984 • 197 citations

beta-Thalassemia in Chinese: use of in vivo RNA analysis and oligonucleotide hybridization in systematic characterization of molecular defects.

1984 • 172 citations

Splicing of adenovirus RNA in a cell-free transcription system.

1983 • 159 citations

RNA Splice Site Selection: Evidence for a 5′ → 3′ Scanning Model

1983 • 92 citations

"Silent" nucleotide substitution in a beta+-thalassemia globin gene activates splice site in coding sequence RNA.

1983 • 90 citations

Processing of the mouse β-globin mRNA precursor: at least two cleavage-ligation reactions are necessary to excise the larger intervening sequence

1979 • 84 citations

Abnormal splice in a mutant human beta-globin gene not at the site of a mutation.

1983 • 80 citations

Processing of high molecular weight ovalbumin and ovomucoid precursor RNAs to messenger RNA

1980 • 79 citations

The orderly splicing of the first three leaders of the adenovirus-2 major late transcript

1982 • 57 citations

Splicing patterns of nuclear precursors to the mRNA for adenovirus 2 DNA binding protein

1979 • 57 citations

A transcription map for the rabbit β-globin gene

1981 • 47 citations

Identification, organization and processing intermediates of the putative precursors of Xenopus vitellogenin messenger RNA

1980 • 41 citations

Cloning specific complete polyadenylylated 3'-terminal cDNA segments

1985 • 17 citations

Nuclear precursor molecules of the two beta-globin mRNAs in Friend erythroleukemia cells.

1982 • 16 citations

Nuclear RNA sequences coding for alpha and beta globins in erythroid cells: evidence for multiple intermediate molecules

1979 • 5 citations