Effects of combined glutamate and platelet-activating factor inhibition on the outcome of focal cerebral ischaemia–an initial screening study

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Thresholds in cerebral ischemia - the ischemic penumbra.

1981 • 2,780 citations

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

1986 • 2,584 citations

A Semiautomated Method for Measuring Brain Infarct Volume

1990 • 1,610 citations

Viability thresholds and the penumbra of focal ischemia

1994 • 1,358 citations

Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.

1986 • 1,257 citations

Role of Oxidants in Ischemic Brain Damage

1996 • 1,037 citations

Experimental studies of ischemic brain edema

1986 • 932 citations

NMDA Antagonist Neurotoxicity: Mechanism and Prevention

1991 • 837 citations

Middle Cerebral Artery Occlusion in the Rat by Intraluminal Suture

1996 • 772 citations

Experimental studies of ischemic brain edema : a new experimental study of ischemic brain edema : 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area

1986 • 770 citations

Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons.

1991 • 741 citations

Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats.

1993 • 706 citations

Rodent models of cerebral ischemia.

1989 • 663 citations

Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke.

1992 • 617 citations

Free Radicals and Brain Damage

1993 • 527 citations

Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion.

1989 • 516 citations

Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra

1996 • 507 citations

Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat).

1994 • 491 citations

Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro

1985 • 464 citations

Laboratory Animal Anaesthesia

1996 • 437 citations

Excitatory amino acid transmission

1987 • 430 citations

Cytokines, inflammation, and brain injury: role of tumor necrosis factor-alpha.

1994 • 421 citations

The Quantification of Cerebral Infarction following Focal Ischemia in the Rat: Influence of Strain, Arterial Pressure, Blood Glucose Concentration, and Age

1988 • 393 citations

Pathogenetic similarity of strokes in stroke-prone spontaneously hypertensive rats and humans.

1976 • 372 citations

Neuronal Necrosis After Middle Cerebral Artery Occlusion in Wistar Rats Progresses at Different Time Intervals in the Caudoputamen and the Cortex

1995 • 349 citations

Infarct Rim: Effect of Hyperglycemia on Direct Current Potential and [¹⁴C]2-Deoxyglucose Phosphorylation

1986 • 334 citations

Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat

1992 • 309 citations

Focal Cerebral Ischaemia in the Rat: 2. Regional Cerebral Blood Flow Determined by [¹⁴C]Iodoantipyrine Autoradiography following Middle Cerebral Artery Occlusion

1981 • 306 citations

Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia.

1987 • 302 citations

Protection against ischaemic neuronal damage by drugs acting on excitatory neurotransmission.

1990 • 298 citations

Cortical Negative DC Deflections following Middle Cerebral Artery Occlusion and KCl-Induced Spreading Depression: Effect on Blood Flow, Tissue Oxygenation, and Electroencephalogram

1994 • 297 citations

Experimental studies of ischemic brain edema. 1. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area

1986 • 294 citations

Pathophysiology of acute ischaemic stroke

1992 • 292 citations

Production and effects of platelet-activating factor in the rat brain

1988 • 205 citations

Enhancement of hippocampal excitatory synaptic transmission by platelet-activating factor

1992 • 201 citations

BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage.

1993 • 180 citations

Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons

1992 • 175 citations

Effect of pretreatment with the calcium antagonist nimodipine on local cerebral blood flow and histopathology after middle cerebral artery occlusion

1985 • 173 citations

Evaluation of 2,3,5-triphenyltetrazolium chloride staining to delineate rat brain infarcts.

1991 • 170 citations

Effects of a platelet activating factor antagonist (BN 52021) on free fatty acids, diacylglycerols, polyphosphoinositides and blood flow in the gerbil brain: Inhibition of ischemia-reperfusion induced cerebral injury

1987 • 159 citations

Experimental Antileukocyte Interventions in Cerebral Ischemia

1996 • 158 citations

Focal cerebral ischemia in the rat: Topography of hemodynamic and histopathological changes

1984 • 157 citations

Limiting Ischemic Injury by Inhibition of Excitatory Amino Acid Release

1993 • 154 citations

Middle cerebral artery occlusion without craniectomy in rats. Which method works best?

1993 • 153 citations

Cerebroprotective Effect of Lamotrigine After Focal Ischemia in Rats

1995 • 148 citations

Nitric oxide and focal cerebral ischemia: multiplicity of actions and diverse outcome.

1994 • 144 citations

Is there a case for PAF antagonists in the treatment of ischemie states?

1989 • 139 citations

PAF Antagonist Ginkgolide B Reduces Postischemic Neuronal Damage in Rat Brain Hippocampus

1990 • 130 citations

Dorsal cerebral arterial collaterals of the rat

1982 • 126 citations

Extracellular neurotransmitter changes in cerebral ischaemia.

1995 • 122 citations

Combined therapy with MK‐801 and nimodipine for protection of ischemic brain damage

1991 • 118 citations

Osmotic Opening of the Blood-Brain Barrier in the Monkey without Associated Neurological Deficits

1973 • 116 citations

Triphenyltetrazolium chloride (TTC) as a marker for ischaemic changes in rat brain following permanent middle cerebral artery occlusion

1991 • 113 citations

Antagonism of non-NMDA receptors augments the neuroprotective effect of NMDA receptor blockade in cortical cultures subjected to prolonged deprivation of oxygen and glucose

1991 • 110 citations

Stroke Therapy

1991 • 108 citations

The pharmacology of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate antagonists and their role in cerebral ischaemia.

1994 • 106 citations

Evidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits.

1990 • 106 citations

Intravenous Infusion of Adrenomedullin and Increase in Regional Cerebral Blood Flow and Prevention of Ischemic Brain Injury after Middle Cerebral Artery Occlusion in Rats

1997 • 103 citations

Combination therapy protects ischemic brain in rats. A glutamate antagonist plus a gamma-aminobutyric acid agonist.

1994 • 96 citations

Do NMDA Antagonists Prevent Neuronal Injury? Yes.

1992 • 94 citations

The role of strain/vendor differences on the outcome of focal ischemia induced by intraluminal middle cerebral artery occlusion in the rat

1995 • 90 citations

CORRELATION OF TRIPHENYLTETRAZOLIUM CHLORIDE PERFUSION STAINING WITH CONVENTIONAL NEUROHISTOLOGY IN THE DETECTION OF EARLY BRAIN ISCHAEMIA

1988 • 90 citations

The dose-response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischemia model

1992 • 89 citations

Laboratory animal anaesthesia : an introduction for research workers and technicians

1987 • 85 citations

Recovery of Postischemic Brain Metabolism and Function Following Treatment with a Free Radical Scavenger and Platelet‐Activating Factor Antagonists

1991 • 83 citations

Induction of leukocytic infiltrates in rabbit skin by acetyl glyceryl ether phosphorylcholine.

1982 • 82 citations

Rodent models of focal ischemia.

1995 • 82 citations

Low Dose L-NAME Reduces Infarct Volume in the Rat MCAO/Reperfusion Model

1993 • 76 citations

Platelet-activating factor and progressive brain damage following focal brain injury

1990 • 74 citations

Platelet activating factor receptor blockade enhances recovery after multifocal brain ischemia

1987 • 64 citations

Principles of Neuroanatomy

1981 • 48 citations

Combination therapy with nimodipine and dizocilpine in a rat model of transient forebrain ischemia.

1992 • 48 citations

Over-additive protective effect of dizocilpine and NBQX against neuronal damage

1994 • 47 citations

Principles of neuroanatomy

1982 • 47 citations

Platelet-activating factor mediates procoagulant activity on the surface of endothelial cells by promoting leukocyte adhesion

1995 • 46 citations

Platelet-Activating Factor in Brain Regions After Transient Ischemia in Gerbils

1996 • 42 citations

Stroke Therapy

1993 • 41 citations

Evidence against High Extracellular Glutamate Promoting the Elicitation of Spreading Depression by Potassium

1996 • 40 citations

Changes in [3H]PAF binding and PAF concentrations in gerbil brain after bilateral common carotid artery occlusion: a quantitative autoradiographic study

1994 • 38 citations

Mild Hypothermia and MK-801 Have Similar But Not Additive Degrees of Cerebroprotection in the Rat Permanent Focal Ischemia Model

1994 • 38 citations

Anticonvulsant activity of MK-801 and Nimodipine alone and in combination against pentylenetetrazole and strychnine

1989 • 37 citations

Synergism between diltiazem and MK-801 but not APV in protecting hippocampal slices against hypoxic damage

1995 • 33 citations

Infarct reduction by the platelet activating factor antagonist apafant in rats.

1992 • 30 citations

MK-801 Reduces Extensive Infarction after Suture Middle Cerebral Artery Occlusion in Rats

1993 • 24 citations

Combination therapy with U74006F (tirilazad mesylate), MK-801, insulin and diazepam in transient forebrain ischaemia

1995 • 21 citations

Neuroprotective synergism of 2-amino-3-phosphonoproprionate (d,l-AP3) and MK-801 against ibotenate induced brain injury

1992 • 13 citations

Digital dyslexia. Neural network mimics the effects of stroke.

1991 • 13 citations

PAF antagonist, BN52021, inhibits [3H]D-aspartate release after ischaemia in vitro

1994 • 11 citations

Platelet-activating factor inhibits (Na+,K+) ATPase activity in rat brain

1994 • 11 citations

Effect of Platelet-Activating Factor Antagonist on Brain Injury in Rats

1994 • 6 citations

A Glimpse to the Future: MultitherapyTrials

1995 • 5 citations

Brain electrobiogenesis protection induced by nimodipine and MK-801 during acute hypoxia in hypertensive rats

1995 • 3 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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