Aging Effects on the Startle Response and Startle Plasticity in Fischer F344 Rats

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis*

1986 • 2,235 citations

Prestimulus Effects on Human Startle Reflex in Normals and Schizophrenics

1978 • 1,173 citations

Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging

1985 • 1,129 citations

Gating and Habituation of the Startle Reflex in Schizophrenic Patients

1992 • 1,030 citations

The acute effects of corticosteroids on cognition: integration of animal and human model studies

1997 • 1,019 citations

Reflex modification in the domain of startle: I. Some empirical findings and their implications for how the nervous system processes sensory input.

1980 • 783 citations

Fear-potentiated startle: A neural and pharmacological analysis

1993 • 736 citations

Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats.

1995 • 656 citations

Dopaminergic stimulation disrupts sensorimotor gating in the rat

1988 • 609 citations

Stress Down-Regulates Corticosterone Receptors in a Site-Specific Manner in the Brain*

1984 • 586 citations

Basal cortisol levels and cognitive deficits in human aging

1994 • 564 citations

Spatial learning and motor deficits in aged rats

1984 • 509 citations

Hippocampal Aging and Adrenocorticoids: Quantitative Correlations

1978 • 486 citations

The startle pattern

1939 • 481 citations

Fear‐Potentiated Startle in Humans: Effects of Anticipatory Anxiety on the Acoustic Blink Reflex

1991 • 454 citations

Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats

1990 • 428 citations

Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat*1

1989 • 375 citations

Corticotropin-releasing factor potentiates acoustic startle in rats: Blockade by chlordiazepoxide

1986 • 301 citations

Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging

1992 • 294 citations

Nicotinic and muscarinic subtypes in the human brain: Changes with aging and dementia

1992 • 269 citations

Regional changes in brain glucose metabolism reflect cognitive impairments in aged rats

1984 • 246 citations

Neuron numbers and sizes in aging brain: Comparisons of human, monkey, and rodent data

1988 • 243 citations

Fear-potentiated startle in posttraumatic stress disorder

1995 • 234 citations

Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs

1995 • 231 citations

Baseline and fear-potentiated startle in panic disorder patients

1994 • 210 citations

Habituation of the Blink Reflex in Normals and Schizophrenic Patients

1982 • 209 citations

Decreased dopamine transporters with age in healthy human subjects

1994 • 205 citations

Age-dependent alterations in hippocampal synaptic plasticity: Relation to memory disorders

1988 • 204 citations

Effect of Age on D2 Dopamine Receptors in Normal Human Brain Measured by Positron Emission Tomography and 11C-Raclopride

1993 • 187 citations

Delay-dependent short-term memory deficits in aged rats

1988 • 183 citations

Multiple serotonin receptor subtypes modulate prepulse inhibition of the startle response in rats

1994 • 179 citations

Monoamine neurons in aging and Alzheimer's disease

1993 • 175 citations

Glucocorticoids, hippocampal corticosteroid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats

1995 • 174 citations

Increased sensitivity to the sensorimotor gating-disruptive effects of apomorphine after lesions of medial prefrontal cortex or ventral hippocampus in adult rats

1995 • 166 citations

Corticosterone receptors decline in a site-specific manner in the aged rat brain

1983 • 162 citations

Spatial and Temporal Memory in 20 and 60 Year Olds

1981 • 148 citations

Biochemical Evidence of Selective Nerve Cell Changes in the Normal Ageing Human and Rat Brain

1983 • 145 citations

Memory for spatial information in young and old adults.

1983 • 141 citations

Age-related impairments in spatial memory are independent of those in sensorimotor skills

1989 • 140 citations

Cognitive Mapping and Elderly Adults: Verbal and Location Memory for Urban Landmarks

1984 • 135 citations

Deficient Sensorimotor Gating After 6‐Hydroxydopamine Lesion of the Rat medial Prefrontal Cortex is Reversed by Haloperidol

1994 • 128 citations

Effects of aging and dementia upon recent visuospatial memory

1984 • 121 citations

Hippocampal modulation of acoustic startle and prepulse inhibition in the rat

1992 • 118 citations

Individual differences in hypothalamic-pituitary-adrenal activity in later life and hippocampal aging

1995 • 103 citations

Age-associated impairments in a test of attention: evidence for involvement of cholinergic systems

1995 • 98 citations

Age-related alterations of hypothalamic-pituitary-adrenal axis function in male Fischer 344 rats.

1994 • 93 citations

Spatial learning deficits in the aged rat: neuroanatomical and neurochemical correlates

1994 • 92 citations

Discrepant Findings of Clozapine Effects on Prepulse Inhibition of Startle: Is It the Route or the Rat?

1998 • 88 citations

Prepulse inhibition as a screening test for potential antipsychotics

1991 • 83 citations

Sensory Gating and Inhibitory Function in Late-life Schizophrenia

1993 • 83 citations

Differential Startle Amplitude and Corticosterone Response in Rats

1992 • 82 citations

Differences between three rat strains in sensitivity to prepulse inhibition of an acoustic startle response: influence of apomorphine and phencyclidine pretreatment

1994 • 78 citations

Regional patterns of cholinergic and glutamate activity in the developing and aging human brain

1993 • 77 citations

Changes in Enzymes of the Cholinergic System and Acetylcholine Release in the Cerebra of Aging Male Fischer Rats

1983 • 73 citations

Decreased density, but not number, N-methyl-D-aspartate, glycine and phencyclidine binding sites in hippocampus of senescent rats

1990 • 70 citations

Longitudinal study on age-related changes of working and reference memory in the rat

1991 • 69 citations

Habituation of tactile startle is altered by drugs acting on serotonin-2 receptors

1988 • 66 citations

Detection and quantitation of 5-HT1A and 5-HT2A receptor mRNAs in human hippocampus using a reverse transcriptase-polymerase chain reaction (RT-PCR) technique and their correlation with binding site densities and age

1994 • 62 citations

The neuroendocrinology of stress and aging

1984 • 60 citations

Endocrine and behavioral effects of airpuff-startle in rats

1996 • 52 citations

Elderly men and women are less responsive to startling noises: N1, P3 and blink evidence

1995 • 48 citations

Age-related alterations of hypothalamic-pituitary-adrenal axis function in male Fischer 344 rats

1994 • 38 citations

Reduced Expression of the Molecular Markers of Dopaminergic Neuronal Atrophy in the Aging Rat Brain

1995 • 35 citations

Dissociation of tactile and acoustic components in air puff startle

1991 • 35 citations

Effects of piracetam on indices of cognitive function in a delayed alternation task in young and aged rats

1994 • 31 citations

Age-related alterations in noradrenergic neurotransmission in Sprague-Dawley and Fischer 344 rat strains

1983 • 28 citations

NMDA receptors in the pontine brainstem are necessary for fear potentiation of the startle response

1996 • 28 citations

Age-related behavioural, neurochemical and radioligand binding changes in the central 5-HT system of Sprague-Dawley rats

1993 • 27 citations

Age, sex and strain comparison of habituation of the startle response in the rat

1985 • 26 citations

The effects of age and attention upon reflex inhibition

1986 • 14 citations