Individual differences in hypothalamic-pituitary-adrenal activity in later life and hippocampal aging

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

Human Aging: Usual and Successful

1987 • 3,185 citations

Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions*

1984 • 3,073 citations

The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis

1992 • 3,026 citations

Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation

1985 • 2,530 citations

The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis*

1986 • 2,235 citations

Cell Damage in the Brain: A Speculative Synthesis

1981 • 1,827 citations

The Role of the Hippocampus in Feedback Regulation of the Hypothalamic-Pituitary-Adrenocortical Axis*

1991 • 1,690 citations

Adrenal steroid receptors and actions in the nervous system

1986 • 1,231 citations

Corticosteroid Inhibition of ACTH Secretion*

1984 • 1,212 citations

Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging

1985 • 1,129 citations

Effect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus

1988 • 1,068 citations

Hypothalamic Control of Adrenocorticotropin Secretion: Advances since the Discovery of 41-Residue Corticotropin-Releasing Factor

1986 • 874 citations

Brain corticosteroid receptor balance and homeostatic control

1991 • 858 citations

Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome

1992 • 831 citations

Neuron numbers and dendritic extent in normal aging and Alzheimer's disease

1987 • 769 citations

Hippocampal damage associated with prolonged and fatal stress in primates

1989 • 746 citations

Glucocorticoid-sensitive hippocampal neurons are involved in terminating the adrenocortical stress response.

1984 • 729 citations

Inverted‐U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation

1992 • 671 citations

Regulation of ACTH Secretion: Variations on a Theme of B

1987 • 668 citations

Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning.

1992 • 589 citations

Stress Down-Regulates Corticosterone Receptors in a Site-Specific Manner in the Brain*

1984 • 586 citations

Basal cortisol levels and cognitive deficits in human aging

1994 • 564 citations

Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats

1995 • 527 citations

Selective Loss of Hippocampal Granule Cells in the Mature Rat Brain After Adrenalectomy

1989 • 520 citations

Brain Aging Correlates: Retardation by Hormonal-Pharmacological Treatments

1981 • 519 citations

Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning.

1992 • 512 citations

Brain damage induced by prenatal exposure to dexamethasone in fetal rhesus macaques. I. Hippocampus

1990 • 505 citations

Prolonged Ca ²⁺ -Dependent Afterhyperpolarizations in Hippocampal Neurons of Aged Rats

1984 • 489 citations

Neonatal Handling Alters Adrenocortical Negative Feedback Sensitivity and Hippocampal Type II Glucocorticoid Receptor Binding in the Rat

1989 • 470 citations

Mediation by Corticotropin Releasing Factor (CRF) of Adenohypophysial Hormone Secretion

1986 • 443 citations

Behavioral stress impairs long-term potentiation in rodent hippocampus

1987 • 441 citations

Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats

1990 • 428 citations

A mechanism for glucocorticoid toxicity in the hippocampus: increased neuronal vulnerability to metabolic insults

1985 • 406 citations

Stress, Feedback and Facilitation in the Hypothalamo‐Pituitary‐Adrenal Axis

1992 • 398 citations

Effects of Glucocorticoids and Norepinephrine on the Excitability in the Hippocampus

1989 • 383 citations

Endocrinology and Metabolism.

1988 • 376 citations

The effects of neonatal handling on the development of the adrenocortical response to stress: Implications for neuropathology and cognitive deficits in later life

1991 • 365 citations

Glucocorticoids Inhibit Glucose Transport and Glutamate Uptake in Hippocampal Astrocytes: Implications for Glucocorticoid Neurotoxicity

1991 • 357 citations

Glucocorticoids Inhibit Glucose Transport in Cultured Hippocampal Neurons and Glia

1990 • 339 citations

Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications.

1991 • 338 citations

Short-term glucocorticoid manipulations affect neuronal morphology and survival in the adult dentate gyrus

1990 • 336 citations

Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system.

1993 • 335 citations

Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene

1992 • 313 citations

The adrenocorticol stress-response in the aged male rat: Impairment of recovery from stress

1983 • 288 citations

Glucocorticoid toxicity in the hippocampus: reversal by supplementation with brain fuels

1986 • 288 citations

Depressed Mood and Other Psychiatric Manifestations of Cushingʼs Syndrome: Relationship to Hormone Levels

1981 • 287 citations

Neuropsychiatric Manifestations of Patients With Cushing's Syndrome

1981 • 276 citations

Possible Connections between Stress, Diabetes, Obesity, Hypertension and Altered Lipoprotein Metabolism that may Result in Atherosclerosis

1989 • 275 citations

Corticosteroid Modulation of Hippocampal Potentials: Increased Effect with Aging

1989 • 274 citations

Hemorrhage-Induced Secretion of Corticotropin-Releasing Factor-Like Immunoreactivity into the Rat Hypophysial Portal Circulation and Its Inhibition by Glucocorticoids*

1984 • 260 citations

Spatial learning deficits in old rats: A model for memory decline in the aged

1988 • 255 citations

Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging

1991 • 255 citations

Antidepressants Increase Glucocorticoid and Mineralocorticoid Receptor mRNA Expression in Rat Hippocampus in vivo

1992 • 255 citations

Telemetered Recording of Hormone Effects on Hippocampal Neurons

1971 • 254 citations

Postnatal handling attenuates certain neuroendocrine, anatomical, and cognitive dysfunctions associated with aging in female rats

1991 • 251 citations

Circadian rhythms of melatonin and cortisol in aging

1989 • 249 citations

Cortisol and Alzheimer's disease, I: Basal studies

1986 • 249 citations

Current Topics in Neuroendocrinology

1983 • 248 citations

Steroids and Apparent Cerebral Atrophy on Computed Tomography Scans

1978 • 246 citations

Regional changes in brain glucose metabolism reflect cognitive impairments in aged rats

1984 • 246 citations

Cortisol Hypersecretion and Cognitive Impairment in Depression

1984 • 238 citations

The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications

1992 • 238 citations

Do glucocorticoid concentrations rise with age in the rat?

1992 • 209 citations

Glucocorticoid endangerment of hippocampal neurons is NMDA-receptor dependent

1990 • 207 citations

Basal ACTH, Corticosterone and Corticosterone-Binding Globulin Levels over the Diurnal Cycle, and Age-Related Changes in Hippocampal Type I and Type II Corticosteroid Receptor Binding Capacity in Young and Aged, Handled and Nonhandled Rats

1992 • 200 citations

Reversibility of Cerebral Atrophy in Anorexia Nervosa and Cushingʼs Syndrome

1977 • 187 citations

Chapter 2 Glucocorticoids, hippocampal damage and the glutamatergic synapse

1990 • 181 citations

Mineralocorticoid receptor-mediated changes in membrane properties of rat CA1 pyramidal neurons in vitro.

1990 • 176 citations

Glucocorticoids, hippocampal corticosteroid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats

1995 • 174 citations

Roles of type I and II corticosteroid receptors in regulation of basal activity in the hypothalamo-pituitary-adrenal axis during the diurnal trough and the peak: evidence for a nonadditive effect of combined receptor occupation.

1994 • 172 citations

Corticosterone receptors decline in a site-specific manner in the aged rat brain

1983 • 162 citations

Local Cerebral Glucose Utilization Is Increased in Acutely Adrenalectomized Rats

1988 • 162 citations

Corticotropin-Releasing Factor-like Immunoreactivity in Senile Dementia of the Alzheimer Type

1985 • 161 citations

Regulation of Glucocorticoid Receptors in Brain by Corticosterone Treatment of Adrenalectomized Rats

1982 • 159 citations

Elevated Corticosterone Levels

1984 • 154 citations

Serotonin regulates type II corticosteroid receptor binding in hippocampal cell cultures

1990 • 153 citations

The adrenocortical axis in the aged rat: Impaired sensitivity to both fast and delayed feedback inhibition

1986 • 149 citations

HISTOLOGICAL CHANGES IN THE ORGANS AND TISSUES OF MIGRATING AND SPAWNING PACIFIC SALMON (GENUS ONCORHYNCHUS)¹

1960 • 146 citations

Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system

1993 • 144 citations

Glucocorticoid Feedback Inhibition of Adrenocorticotropic Hormone Secretagogue Release

1990 • 142 citations

Adrenocortical Steroids and the Brain

1987 • 141 citations

The brain as a target for adrenocortical steroids: Cognitive implications

1992 • 136 citations

Antidepressants regulate glucocorticoid receptor messenger RNA concentrations in primary neuronal cultures

1989 • 134 citations

[3H]Dexamethasone binding in rat frontal cortex

1985 • 132 citations

Distribution of glucocorticoid and mineralocorticoid receptor messenger RNA expression in human postmortem hippocampus

1991 • 132 citations

Glucocorticoid Endangerment of the Hippocampus: Tissue, Steroid and Receptor Specificity

1990 • 130 citations

Neuropsychological Deficits in Cushing??s Syndrome

1980 • 128 citations

Individual Differences in the Hypothalamic‐Pituitary‐Adrenal Stress Response and the Hypothalamic CRF Systema

1993 • 121 citations

The effect of aging on stress responsiveness and central corticosteroid receptors in the Brown Norway rat

1992 • 119 citations

Increased glucocorticoid receptor gene promoter activity after antidepressant treatment.

1992 • 114 citations

The CRH Motoneuron: Differential Peptide Regulation in Neurons with Possible Synaptic, Paracrine, and Endocrine Outputs

1987 • 107 citations

Stress and Glucocorticoids in Aging

1987 • 106 citations

Diminished Diurnal Secretion of Adrenocorticotropin (ACTH), But Not Corticosterone, in Old Male Rats: Possible Relation to Increased Adrenal Sensitivity to ACTHin Vivo*

1987 • 105 citations

Cerebral Atrophy Following ACTH Therapy

1980 • 103 citations

Serum corticosterone level predicts the magnitude of hippocampal primed burst potentiation and depression in urethane-anesthetized rats

1991 • 103 citations

Exposure to a novel environment interferes with the induction of hippocampal primed burst potentiation in the behaving rat

1990 • 96 citations

Central 5,7‐Dihydroxytryptamine Lesions Decrease Hippocampal Glucocorticoid and Mineralocorticoid Receptor Messenger Ribonucleic Acid Expression

1990 • 95 citations

Neurotrophic ACTH analogue promotes plasticity of type I corticosteroid receptor in brain of senescent male rats

1988 • 95 citations

Age-related alterations of hypothalamic-pituitary-adrenal axis function in male Fischer 344 rats.

1994 • 93 citations

Hyperadrenocorticism in spawning migratory and nonmigratory rainbow trout (Salmo gairdnerii); Comparison with pacific salmon (genus Oncorhynchus)

1961 • 92 citations

Adrenocortical Responsiveness to Stress and ACTH in Aging Rats

1970 • 86 citations

Regulation of Hypophysiotropic Factors Mediating ACTH Secretiona

1987 • 84 citations

Some age-related changes in pituitary-adrenal function in the male laboratory rat.

1978 • 84 citations

Stress-induced occupancy and translocation of hippocampal glucocorticoid receptors

1988 • 83 citations

Male Fischer 344/N rats show a progressive central impairment of the hypothalamic-pituitary-adrenal axis with advancing age.

1994 • 81 citations

Roles of type I and II corticosteroid receptors in regulation of basal activity in the hypothalamo-pituitary-adrenal axis during the diurnal trough and the peak: evidence for a nonadditive effect of combined receptor occupation

1994 • 76 citations

Equivalent affinity of aldosterone and corticosterone for type I receptors in kidney and hippocampus: Direct binding studies

1987 • 73 citations

Immunohistochemical study of neurons containing corticotropin‐releasing factor in Alzheimer's disease

1987 • 64 citations

Corticotropin-releasing factor-like immunoreactivity in senile dementia of the Alzheimer type. Reduced cortical and striatal concentrations

1985 • 55 citations

Age-related changes in glucocorticoid receptor binding and mRNA levels in the rat brain and pituitary

1991 • 52 citations

Temporally graded, age-related impairments in spatial memory in the rat

1989 • 52 citations

Neuropsychiatric manifestations of patients with Cushing's syndrome. Relationship to cortisol and adrenocorticotropic hormone levels

1981 • 49 citations

The development of sex differences in the adrenal morphology and responsiveness in stress of rats from birth to the end of life

1976 • 47 citations

law of deviation of homeostasis and diseases of aging

1981 • 45 citations

Glucocorticoid receptor gene expression is unaltered in hippocampal neurons in Alzheimer's disease

1993 • 45 citations

Male Fischer 344/N rats show a progressive central impairment of the hypothalamic-pituitary-adrenal axis with advancing age

1994 • 40 citations

Glucocorticoid binding sites in human temporal cortex

1988 • 39 citations

Age-related alterations of hypothalamic-pituitary-adrenal axis function in male Fischer 344 rats

1994 • 38 citations

Medial septal cholinergic lesions increase hippocampal mineralocorticoid and glucocorticoid receptor messenger RNA expression

1992 • 30 citations

Feedback Actions of Adrenal Steroid Hormones

1982 • 22 citations

Réactivité au ‘stress’ et capacité d’adaptation à une situation inhabituelle chez le rat jeune, adulte et âgé

1964 • 22 citations

Postmortem decay in glucocorticoid binding in human and primate brain

1988 • 16 citations

High intensity venous sampling reveals subtle alterations in plasma adrenocorticotropin patterns in old rats.

1993 • 13 citations

Kainic Acid‐Induced Decrease in Hippocampal Corticosteroid Receptors

1992 • 11 citations

[REACTION TO "STRESS" AND CAPACITY OF ADAPTATION TO AN UNUSUAL SITUATION IN YOUNG, ADULT AND AGED RATS].

1964 • 7 citations

Entorhinal Cortex Lesions Transiently Alter Glucocorticoid but Not Mineralocorticoid Receptor Gene Expression in the Rat Hippocampus

1993 • 5 citations

High intensity venous sampling reveals subtle alterations in plasma adrenocorticotropin patterns in old rats

1993 • 3 citations

Deleted Work

1955 • 0 citations