Monoamine neurons in aging and Alzheimer's disease

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

1991 • 2,375 citations

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

1990 • 2,131 citations

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported

1989 • 1,630 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

1989 • 1,369 citations

Prevalence of Alzheimer's Disease in a Community Population of Older Persons

1989 • 1,128 citations

Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.

1985 • 979 citations

Effect of Deprenyl on the Progression of Disability in Early Parkinson's Disease

1989 • 913 citations

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

1989 • 904 citations

Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal.

1980 • 836 citations

Raphe unit activity in freely moving cats: Correlation with level of behavioral arousal

1979 • 809 citations

The Effect of Deprenyl (Selegiline) on the Natural History of Parkinson's Disease

1989 • 621 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

AETIOLOGY OF PARKINSON'S DISEASE

1983 • 463 citations

Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro

1990 • 456 citations

A Selective Increase in Particulate Superoxide Dismutase Activity in Parkinsonian Substantia Nigra

1989 • 445 citations

Changes in the Brain Catecholamines in Patients with Dementia of Alzheimer Type

1979 • 445 citations

The neuropathology of aminergic nuclei in Alzheimer's disease

1988 • 419 citations

Neuropsychiatric Aspects of Multi-infarct Dementia and Dementia of the Alzheimer Type

1987 • 415 citations

Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease

1985 • 414 citations

Coexistence of cognitive impairment and depression in geriatric outpatients

1982 • 374 citations

Neurochemical Studies of Early-Onset Alzheimer's Disease

1985 • 356 citations

The effect of age on the activity and molecular properties of human brain monoamine oxidase

1980 • 342 citations

Double-blind trial of imipramine in Alzheimer's disease patients with and without depression

1989 • 338 citations

Depression in Patients Referred to a Dementia Clinic

1985 • 330 citations

Influence of age and time interval between death and autopsy on dopamine and 3-methoxytyramine Levels in human basal ganglia

1976 • 328 citations

Sleep, EEG and mental function changes in senile dementia of the Alzheimer's type

1982 • 321 citations

STIMULATORY EFFECT OF <scp>l</scp>‐GLUTAMATE AND RELATED AMINO ACIDS ON [³H]DOPAMINE RELEASE FROM RAT STRIATUM: AN IN VITRO MODEL FOR GLUTAMATE ACTIONS

1979 • 315 citations

Monoamine Innervation of the Cerebral Cortex

1985 • 308 citations

Biochemical changes in Dementia disorders of Alzheimer type (AD/SDAT)

1983 • 296 citations

Aging Produces a Specific Pattern of Striatal Dopamine Loss: Implications for the Etiology of Idiopathic Parkinson's Disease

1992 • 276 citations

Alzheimer's disease: a correlative study.

1986 • 269 citations

Loss of pigmented dopamine-β-hydroxylase positive cells from locus coeruleus in senile dementia of alzheimer's type

1983 • 267 citations

Striatal dopamine deficiency in parkinson's disease: Role of aging

1989 • 266 citations

Increased activity of brain and platelet monoamine oxidase in dementia of Alzheimer type

1980 • 254 citations

Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and down's syndrome

1983 • 250 citations

Major Depression in Primary Dementia

1988 • 241 citations

Aminergic systems in Alzheimer's disease and Parkinson's disease

1987 • 241 citations

Involvement of cholinergic presynaptic receptors of nicotinic and muscarinic types in the control of the spontaneous release of dopamine from striatal dopaminergic terminals in the rat.

1977 • 237 citations

Neurochemical Correlates of Major Depression in Primary Dementia

1990 • 233 citations

Cortical biopsy in Alzheimer's disease: Diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations

1992 • 225 citations

Post-mortem distribution of dopamine and homo-vanillic acid in human brain, variations related to age, and a review of the literature

1979 • 218 citations

The Molecular basis of neuropathology

1981 • 217 citations

EEG sleep in elderly depressed, demented, and healthy subjects

1985 • 216 citations

Presynaptic Serotonergic Dysfunction in Patients with Alzheimer's Disease

1987 • 213 citations

Neurochemical activities in human temporal lobe related to aging and Alzheimer-type changes

1981 • 211 citations

Catecholamine toxicity in cerebral cortex in dissociated cell culture

1988 • 207 citations

Frequency and presentation of depressive symptoms in patients with primary degenerative dementia [published erratum appears in Am J Psychiatry 1987 Apr;144(4):542]

1987 • 201 citations

Evidence of Glutamatergic Denervation and Possible Abnormal Metabolism in Alzheimer's Disease

1988 • 200 citations

Free radical theory of aging: The “free radical” diseases

1984 • 192 citations

Involvement of free radicals in dementia of the Alzheimer type: A hypothesis

1990 • 191 citations

Possible neurotransmitter basis of behavioral changes in alzheimer's disease

1988 • 190 citations

Monoaminergic innervation of the frontal and temporal lobes in Alzheimer's disease

1987 • 185 citations

L-Deprenyl in Alzheimer's Disease

1987 • 180 citations

Efficacy of antipsychotic medications in behaviorally disturbed dementia patients

1982 • 167 citations

Propranolol in the treatment of rage and violent behavior in patients with chronic brain syndromes

1981 • 161 citations

HOMOVANILLIC ACID AND 5‐HYDROXYINDOLEACETIC ACID IN THE CEREBROSPINAL FLUID OF PATIENTS WITH SENILE DEMENTIA, PRESENILE DEMENTIA AND PARKINSONISM

1969 • 160 citations

Monoamine metabolism in senile dementia of Alzheimer type

1983 • 148 citations

A post-mortem study of noradrenergic, serotonergic and GABAergic neurons in Alzheimer's disease

1988 • 146 citations

Biogenic amines in human brain in normal aging, senile dementia, and chronic alcoholism.

1980 • 140 citations

Catecholaminergic neurones assessed ante-mortem in Alzheimer's disease

1987 • 131 citations

Reduced binding of [3H]ketanserin to cortical 5-HT2 receptors in senile dementia of the Alzheimer type

1984 • 130 citations

Cognitive effects of l-deprenyl in Alzheimer's disease

1987 • 127 citations

Excitotoxicity of l-DOPA and 6-OH-DOPA: Implications for Parkinson's and Huntington's diseases

1990 • 127 citations

Disturbances of sleep and cognitive functioning in patients with dementia

1982 • 122 citations

The Effect of Propranolol on Uncontrolled Rage Outbursts in Children and Adolescents with Organic Brain Dysfunction

1982 • 117 citations

Decreased density of human striatal dopamine uptake sites with age

1986 • 116 citations

Dopaminergic system and monoamine oxidase-B Activity in Alzheimer's disease

1988 • 116 citations

A Pilot Study of Haloperidol Treatment of Psychosis and Behavioral Disturbance in Alzheimer's Disease

1989 • 102 citations

Monoaminergic neurotransmitter systems in presenile Alzheimer's disease and in senile dementia of Alzheimer type.

1984 • 98 citations

Brain membrane fluidity and lipid peroxidation in Alzheimer's disease

1990 • 95 citations

The effect of aging on the D1 dopamine receptors in human frontal cortex

1990 • 94 citations

Homovanillic acid and 5-hydroxyindoleacetic acid levels in cerebrospinal fluid of patients with senile dementia of Alzheimer type

2009 • 88 citations

Psychopharmacology of the aging nervous system

1988 • 85 citations

Divergent changes in D-1 and D-2 dopamine binding sites in human brain during aging

1987 • 82 citations

Loxapine in psychogeriatrics: a placebo- and standard-controlled clinical investigation.

1982 • 80 citations

Striatal dopamine receptors in Alzheimer-type dementia

1984 • 75 citations

Age-correlated loss of dopamine uptake sites labeled with [3H]GBR-12935 in human putamen

1989 • 72 citations

Monoamine metabolite concentrations in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia.

1984 • 72 citations

Loxapine in Psychogeriatrics

1982 • 71 citations

The human locus coeruleus in neurology and psychiatry

1981 • 68 citations

Open-trial response to antidepressant treatment in elderly patients with mixed depression and cognitive impairment

1987 • 68 citations

Elevated Density of [³H]Imipramine Binding in Aged Human Brain

1985 • 64 citations

Extracellular concentrations of aspartate and glutamate in rat neostriatum following chemical stimulation of frontal cortex

1989 • 63 citations

Metabolic and functional studies on post-mortem human brain

1983 • 62 citations

Alzheimer's Disease

1969 • 61 citations

Rapid eye movement sleep measures of Alzheimer's-type dementia patients and optimally healthy aged individuals.

1984 • 60 citations

Significance of decreased lumbar CSF levels of HVA and 5-HIAA in Alzheimer's disease

1992 • 57 citations

A Pilot Study of Low-Dose L-Deprenyl in Alzheimer's Disease

1991 • 55 citations

Neurotransmitter dysfunction and atrophy of the caudate nucleus in Alzheimer's disease.

1984 • 55 citations

2,4,5-trihydroxyphenylalanine in solution forms a non-N-methyl-D-aspartate glutamatergic agonist and neurotoxin.

1991 • 54 citations

Platelet MAO activity in primary degenerative dementia

1984 • 52 citations

Homovanillic acid and 5-hydroxyindoleacetic acid in cerebrospinal fluid related to rated mental and motor impairment in senile and presenile dementia.

1970 • 52 citations

Platelet tritiated imipramine binding and MAO activity in Alzheimer's disease patients with agitation and delusions

1988 • 49 citations

ACID MONOAMINE METABOLITES IN CEREBROSPINAL FLUID FROM PATIENTS WITH PRESENILE DEMENTIA (ALZHEIMER'S DISEASE)

1973 • 48 citations

The relationships of aging changes in the basal ganglia to manifestations of Huntington's chorea

1980 • 45 citations

Brain dopamine D-2 receptors in senile dementia

1986 • 42 citations

Are post-mortem biochemical studies of human brain worthwhile?

1988 • 40 citations

Cerebral biopsy in the investigation of presenile dementia due to cerebral atrophy.

1986 • 39 citations

Clinical Brain Imaging: Principles and Applications

1993 • 37 citations

The oxidation of tryptamine by the two forms of monoamine oxidase in human tissues

1986 • 36 citations

Clinical brain imaging : principles and applications

1992 • 34 citations

A 3,4-dihydroxyphenylalanine oxidation product is a glutamatergic agonist in rat cortical neurons

1990 • 33 citations

Depression and Serotonin Metabolism

1985 • 32 citations

Use of propranolol in the treatment of postencephalitic psychosis

1979 • 29 citations

Cognitive neuroscience

1992 • 20 citations

Cerebrospinal Fluid Markers of Alzheimer's Disease

1991 • 19 citations

Relationship between pigment accumulation and age in Alzheimer's disease and Down syndrome

1984 • 18 citations

5-Hydroxyindoleacetic acid and homovanillic acid in the cerebrospinal fluid and caudate nucleus of histologically verified examples of Alzheimer's disease

1985 • 13 citations

Characterization of a Partial cDNA Specific for the High Molecular Weight Microtubule-Associated Protein MAP2 That Encodes Epitopes Shared with Paired Helical Filaments of Alzheimer's Disease

1990 • 11 citations

HOMOVANILLIC ACID AND 5-HYDROXYINDOLEACETIC ACID LEVELS IN CEREBROSPINAL FLUID OF PATIENTS WITH SENILE DEMENTIA OF ALZHEIMER TYPE

1980 • 9 citations

Characterization of a partial cDNA specific for the high molecular weight microtubule-associated protein MAP2 that encodes epitopes shared with paired helical filaments of Alzheimer's disease

1990 • 8 citations

Clinical Neurology of Aging

1986 • 6 citations

Alzheimer??s Disease: Treatment and Long-Term Management

1991 • 1 citations