Enzymology of the reductive bioactivation of SR 4233

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

[6] Statistical analysis of enzyme kinetic data

1979 • 2,002 citations

Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic Studies

1962 • 1,431 citations

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

1988 • 811 citations

[56] DT diaphorase

1967 • 521 citations

SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells

1986 • 391 citations

Enzymatic Basis of Detoxication

1981 • 244 citations

The pharmacology and biochemistry of N-oxides.

1969 • 193 citations

Molecular mechanisms for the hypoxiadependent activation of 3-amino-1,2,4-benzotriazine-1, 4-dioxide (SR 4233)

1988 • 152 citations

The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

1988 • 147 citations

Metabolic Basis of Detoxication

1982 • 142 citations

Nitroreductase activity of mammalian liver aldehyde oxidase.

1973 • 121 citations

Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity.

1988 • 121 citations

Hypoxic cells as specific drug targets for chemotherapy.

1987 • 87 citations

Nitroimidazole bioreductive metabolism

1987 • 83 citations

Xanthine Oxidase and Aldehyde Oxidase

1980 • 75 citations

Reduction of niridazole by rat liver xanthine oxidase

1971 • 74 citations

Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins

1989 • 70 citations

Catalysis of the Direct Transfer of Oxygen from Nicotinamide N-Oxide to Xanthine by Xanthine Oxidase

1966 • 69 citations

Structure-activity relationships for benzotriazine DI-N-oxides

1989 • 64 citations

Reduction of tertiary amine N-oxides by liver preparations: Function of aldehyde oxidase as a major N-oxide reductase

1984 • 64 citations

Enzyme-Directed Bioreductive Drug Development

1990 • 58 citations

Reduction of tertiary amine N-oxides by liver microsomal cytochrome P-450.

1976 • 56 citations

Evidence for the involvement of cytochrome P-450 in tiaramide N-oxide reduction

1974 • 52 citations

Reductive Drug Metabolism

1983 • 45 citations

Identification of two major reduction products of the hypoxic cell toxin 3-amino-1,2,4-benzotriazine-1,4-dioxide

1986 • 44 citations

Preparation and properties of microsomal fractions

1978 • 38 citations

In vitro hepatotoxicity of SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide), a hypoxic cytotoxin and potential antitumor agent.

1989 • 34 citations

Pyridine nucleotide cofactor requirements of indicine N-oxide reduction by hepatic microsomal cytochrome P-450

1980 • 25 citations

Reduction of tertiary amine N-oxides by cytochrome P-450. Mechanism of the stimulatory effect of flavins and methyl viologen.

1978 • 24 citations

Reductive Metabolism of Nitrogen-Containing Functional Groups

1982 • 23 citations

High-performance liquid chromatographic assay for the benzotriazine di-N-oxide (SR 4233) and its reduced metabolites in biological materials

1988 • 15 citations

Drug delivery in cancer treatment II

1990 • 4 citations

Optimised Treatment Modalities for Hypoxic Tumour Cells

1989 • 2 citations