A Mitochondrial Protease with Two Catalytic Subunits of Nonoverlapping Specificities

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

Genomic sequencing.

1984 • 8,343 citations

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

1993 • 1,197 citations

A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector

1987 • 1,181 citations

An improved staining procedure for the detection of the peroxidase activity of cytochrome P-450 on sodium dodecyl sulfate polyacrylamide gels

1976 • 1,060 citations

[27] Preparation of high molecular weight RNA

1991 • 579 citations

Protein Sorting to Mitochondria: Evolutionary Conservations of Folding and Assembly

1990 • 494 citations

Cytochromes c1 and b2 are sorted to the intermembrane space of yeast mitochondria by a stop-transfer mechanism

1992 • 422 citations

Purification of microsomal signal peptidase as a complex.

1986 • 313 citations

Sequence of the leader peptidase gene of Escherichia coli and the orientation of leader peptidase in the bacterial envelope.

1983 • 307 citations

The signal recognition particle in S. cerevisiae

1991 • 299 citations

Successive translocation into and out of the mitochondrial matrix: Targeting of proteins to the intermembrane space by a bipartite signal peptide

1987 • 275 citations

Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space

1992 • 233 citations

Import of proteins into yeast mitochondria: the purified matrix processing protease contains two subunits which are encoded by the nuclear MAS1 and MAS2 genes.

1988 • 219 citations

Signal peptidases in prokaryotes and eukaryotes - a new protease family

1992 • 212 citations

The presequences of two imported mitochondrial proteins contain information for intracellular and intramitochondrial sorting

1986 • 194 citations

Imported mitochondrial proteins cytochrome b2 and cytochrome c1 are processed in two steps.

1982 • 187 citations

SEC11 is required for signal peptide processing and yeast cell growth.

1988 • 185 citations

Inner membrane protease I, an enzyme mediating intramitochondrial protein sorting in yeast.

1991 • 183 citations

MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease.

1988 • 181 citations

Structure, expression and regulation of a nuclear gene encoding a mitochondrial protein: the yeast L(+)-lactate cytochrome c oxidoreductase (cytochrome b2).

1985 • 178 citations

Signal peptidase I of Bacillus subtilis: patterns of conserved amino acids in prokaryotic and eukaryotic type I signal peptidases.

1992 • 163 citations

Assembly of the mitochondrial membrane system. Analysis of structural mutants of the yeast coenzyme QH2-cytochrome c reductase complex.

1988 • 160 citations

Sequencing of the nuclear gene for the yeast cytochrome c1 precursor reveals an unusually complex amino-terminal presequence.

1984 • 157 citations

Import of proteins into yeast mitochondria: the nuclear MAS2 gene encodes a component of the processing protease that is homologous to the MAS1-encoded subunit.

1988 • 149 citations

Mitochondrial inner membrane protease 1 of Saccharomyces cerevisiae shows sequence similarity to the Escherichia coli leader peptidase

1991 • 120 citations

Use of phoA fusions to study the topology of the Escherichia coli inner membrane protein leader peptidase

1989 • 111 citations

Biogenesis of cytochrome c1

1989 • 99 citations

A nuclear mutation prevents processing of a mitochondrially encoded membrane protein in Saccharomyces cerevisiae.

1983 • 99 citations

Molecular cloning and characterization of the Saccharomyces cerevisiae CYT2 gene encoding cytochrome‐c₁– heme lyase

1992 • 99 citations

At least two nuclear gene products are specifically required for translation of a single yeast mitochondrial mRNA.

1986 • 96 citations

One nuclear gene controls the removal of transient pre-sequences from two yeast proteins: one encoded by the nuclear the other by the mitochondrial genome.

1986 • 93 citations

The signal that sorts yeast cytochrome b2 to the mitochondrial intermembrane space contains three distinct functional regions.

1993 • 85 citations

Transport of proteins to the mitochondrial intermembrane space: the ‘matrix-targeting’ and the ‘sorting’ domains in the cytochrome c1 presequence.

1987 • 84 citations

Purification and characterization of hen oviduct microsomal signal peptidase

1987 • 83 citations

Targeting of cytochrome b2 into the mitochondrial intermembrane space: specific recognition of the sorting signal.

1993 • 81 citations

The complete amino acid sequence of bovine heart cytochrome C1

1980 • 80 citations

On the catalytic mechanism of prokaryotic leader peptidase 1

1992 • 73 citations

Yeast signal peptidase contains a glycoprotein and the Sec11 gene product.

1991 • 72 citations

Mitochondrial membrane biogenesis: identification of a precursor to yeast cytochrome c oxidase subunit II, an integral polypeptide.

1980 • 71 citations

Two subunits of the canine signal peptidase complex are homologous to yeast SEC11 protein.

1990 • 71 citations

Mapping of catalytically important domains in Escherichia coli leader peptidase.

1990 • 70 citations

A Subunit of Mammalian Signal Peptidase Is Homologous to Yeast SEC11 Protein

1989 • 69 citations

Membrane topology and biogenesis of eukaryotic signal peptidase.

1993 • 64 citations

Site-directed mutagenesis of a Saccharomyces cerevisiae mitochondrial translation initiation codon.

1991 • 49 citations

Miscleavage at the presequence of rat preprolactin synthesized in pituitary cells incubated with a threonine analog

1981 • 48 citations

Reduced but accurate translation from a mutant AUA initiation codon in the mitochondrial COX2 mRNA of Saccharomyces cerevisiae

1994 • 41 citations

Protein sorting between mitochondrial membranes specified by position of the stop-transfer domain.

1988 • 33 citations

A role for membrane potential in the biogenesis of cytochrome c oxidase subunit II, a mitochondrial gene product

1989 • 26 citations

Electron paramagnetic resonance studies of MN(II) complexes with myosin subfragment 1 and oxygen 17-labeled ligands.

1982 • 19 citations