The effects of aromatic and aliphatic maleimide crosslinkers on anti-CD5 ricin immunotoxins

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

An Efficient mRNA‐Dependent Translation System from Reticulocyte Lysates

1976 • 3,994 citations

Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose

1978 • 2,726 citations

The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis

1964 • 1,214 citations

The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

1987 • 1,153 citations

New procedures for preparation and isolation of conjugates of proteins and a synthetic copolymer of D-amino acids and immunochemical characterization of such conjugates

1979 • 463 citations

Human T cell antigens defined by monoclonal antibodies: the 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin.

1980 • 429 citations

Enzyme Coupled Immunoassay of Insulin Using a Novel Coupling Reagent

1976 • 332 citations

Redesigning Nature's Poisons to Create Anti-Tumor Reagents

1987 • 329 citations

Some Reactions of N-Ethylmaleimide¹

1960 • 277 citations

Antibody-directed cytotoxic agents: use of monoclonal antibody to direct the action of toxin A chains to colorectal carcinoma cells.

1980 • 270 citations

Immunotoxins

1986 • 230 citations

New coupling agents for the synthesis of immunotoxins containing a hindered disulfide bond with improved stability in vivo.

1987 • 205 citations

More useful maleimide compounds for the conjugation of Fab' to horseradish peroxidase through thiol groups in the hinge.

1984 • 201 citations

Kinetics of protein synthesis inactivation by ricin-anti-Thy 1.1 monoclonal antibody hybrids. Role of the ricin B subunit demonstrated by reconstitution.

1982 • 200 citations

Anti-Thy 1.2 monoclonal antibody linked to ricin is a potent cell-type-specific toxin.

1980 • 190 citations

Immunotoxins: Hybrid Molecules Combining High Specificity and Potent Cytotoxicity

1982 • 181 citations

Selective Destruction of Target Cells by Diphtheria Toxin Conjugated to Antibody Directed against Antigens on the Cells

1970 • 162 citations

Anti-T-Cell Reagents for Human Bone Marrow Transplantation: Ricin Linked to Three Monoclonal Antibodies

1983 • 148 citations

Purified immunotoxins that are reactive with human lymphoid cells. Monoclonal antibodies conjugated to the ribosome-inactivating proteins gelonin and the pokeweed antiviral proteins.

1985 • 138 citations

Preparation and characterization of hetero-bifunctional cross-linking reagents for protein modifications.

1981 • 127 citations

Inhibition of Human Acute Lymphoblastic Leukemia Cells by Immunotoxins: Potentiation by Chloroquine

1984 • 124 citations

Monoclonal antibody-ricin A chain conjugate selectively cytotoxic for cells bearing the common acute lymphoblastic leukemia antigen.

1982 • 111 citations

Monoclonal Antibody‐Ricin or Ricin A Chain Hybrids: Kinetic Analysis of Cell Killing for Tumor Therapy

1982 • 109 citations

Chimeric toxins

1981 • 108 citations

Purification of ricin A1, A2, and B chains and characterization of their toxicity.

1986 • 102 citations

Receptors and Recognition: Series A

1978 • 94 citations

Studies on the galactose-binding site of ricin and the hybrid toxin man6P-ricin

1981 • 88 citations

Importance of the Antigen-Binding Valency and the Nature of the Cross-Linking Bond in Ricin A-Chain Conjugates with Antibody

1982 • 84 citations

Marrow purging in autologous bone marrow transplantation for T-lineage acute lymphoblastic leukemia: efficacy of ex vivo treatment with immunotoxins and 4-hydroperoxycyclophosphamide against fresh leukemic marrow progenitor cells

1987 • 82 citations

The Spearman Estimator for Serial Dilution Assays

1961 • 82 citations

GRAFT-VERSUS-HOST DISEASE PREVENTION IN ALLOGENEIC BONE MARROW TRANSPLANTATION FROM HISTOCOMPATIBLE SIBLINGS A PILOT STUDY USING IMMUNOTOXINS FOR T CELL DEPLETION OF DONOR BONE MARROW

1987 • 81 citations

Immunoconjugates : antibody conjugates in radioimaging and therapy of cancer

1987 • 81 citations

Use of multiple T cell-directed intact ricin immunotoxins for autologous bone marrow transplantation

1985 • 77 citations

Comparison of two methods of preparing enzyme-antibody conjugates: Application of these conjugates for enzyme immunoassay

1979 • 71 citations

Combined ex vivo treatment with immunotoxins and mafosfamid: a novel immunochemotherapeutic approach for elimination of neoplastic T cells from autologous marrow grafts.

1985 • 69 citations

Use of multiple T cell-directed intact ricin immunotoxins for autologous bone marrow transplantation

1985 • 57 citations

Characterization and differentiation of CD4-, CD8- thymocytes sorted with the Ly-24 marker.

1988 • 47 citations

Comparison of Two Anti-Thy 1.1-Abrin A-Chain Immunotoxins Prepared With Different Cross-Linking Agents: Antitumor Effects, In Vivo Fate, and Tumor Cell Mutants

1987 • 42 citations

Use of colony assays and anti-T cell immunotoxins to elucidate the immunobiologic features of leukemic progenitor cells in T-lineage acute lymphoblastic leukemia.

1988 • 41 citations

Enzyme Immunoassays of Kanamycin Group Antibiotics with High Sensitivities Using Anti-Kanamycin as a Common Antiserum: Reasoning and Selection of a Heterologous Enzyme Label1

1983 • 38 citations

Cytotoxic effect of anti-Mr 67,000 protein immunotoxins on human tumors in a nude mouse model.

1985 • 37 citations

Kinetics of protein synthesis inactivation in human T-lymphocytes by selective monoclonal antibody-ricin conjugates.

1985 • 35 citations

Combined immunochemotherapy of human solid tumors in nude mice.

1987 • 35 citations

Anti-T cell monoclonal antibodies conjugated to ricin as potential reagents for human GVHD prophylaxis: effect on the generation of cytotoxic T cells in both peripheral blood and bone marrow.

1984 • 33 citations

Elimination of clonogenic T-leukemic cells from human bone marrow using anti-Mr 65,000 protein immunotoxins.

1984 • 32 citations

Enzyme Immunoassay of Blasticidin S with High Sensitivity: A New and Convenient Method for Preparation of Immunogenic (Hapten-Protein) Conjugates

1982 • 30 citations

Antigenic modulation by anti-CD5 immunotoxins.

1986 • 25 citations

IMMUNOTOXINS FOR EX VIVO MARROW PURGING IN AUTOLOGOUS BONE MARROW TRANSPLANTATION FOR ACUTE NONLYMPHOCYTIC LEUKEMIA

1988 • 22 citations

MONOCLONAL ANTIBODY TOXIN CONJUGATES FOR EXPERIMENTAL GRAFT-VERSUS-HOST DISEASE PROPHYLAXIS REAGENTS SELECTIVELY REACTIVE WITH T CELLS AND NOT MURINE STEM CELLS

1983 • 21 citations

Human leukemia cell binding and killing by anti-CD5 radioimmunotoxins

1987 • 15 citations

Immunotoxins containing ricin

1988 • 14 citations

The spatial organization of the active sites of the bifunctional oligomeric enzyme tryptophan synthase: Cross-linking by a novel method

1981 • 14 citations

A flexible peptide spacer increases the efficacy of holoricin anti-T cell immunotoxins.

1988 • 11 citations

Immunotoxins for ex vivo bone marrow purging in human bone marrow transplantation

1988 • 9 citations

Modulation of anaphylatoxin desarginine complement c 5a induced biological reactions by platelet activating factor paf acether and structural analog

1985 • 5 citations

Antibody-ricin conjugates: a method of linkage which blocks the galactose binding site of ricin.

1984 • 2 citations