Purified immunotoxins that are reactive with human lymphoid cells. Monoclonal antibodies conjugated to the ribosome-inactivating proteins gelonin and the pokeweed antiviral proteins.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Tissue sulfhydryl groups

1959 • 25,130 citations

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

An Efficient mRNA‐Dependent Translation System from Reticulocyte Lysates

1976 • 3,994 citations

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

1978 • 2,146 citations

Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture

1977 • 2,134 citations

Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent

1978 • 1,226 citations

An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein

1984 • 1,132 citations

Characterization of a human B lymphocyte-specific antigen.

1980 • 1,098 citations

Conjugation of antibodies with fluorochromes: Modifications to the standard methods

1976 • 757 citations

A monoclonal antibody to human acute lymphoblastic leukaemia antigen

1980 • 748 citations

Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.

1979 • 638 citations

Lysosomes revisited

1983 • 427 citations

The Collected Papers of Paul Ehrlich

2013 • 363 citations

Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A.

1980 • 321 citations

Molecular Action of Toxins and Viruses

1982 • 298 citations

Immunotoxins: A New Approach to Cancer Therapy

1983 • 282 citations

Identification of a cell surface protein, p97, in human melanomas and certain other neoplasms.

1980 • 259 citations

Characterization of a leukemic cell line of the pre‐B phenotype

1979 • 257 citations

Monoclonal antibodies defining serologically distinct HLA-D/DR related Ia-like antigens in man

1981 • 247 citations

Kinetics of protein synthesis inactivation by ricin-anti-Thy 1.1 monoclonal antibody hybrids. Role of the ricin B subunit demonstrated by reconstitution.

1982 • 200 citations

The Preparation and Cytotoxic Properties of Antibody‐Toxin Conjugates

1982 • 199 citations

Kinetics of cytotoxicity induced by immunotoxins. Enhancement by lysosomotropic amines and carboxylic ionophores.

1984 • 194 citations

Anti-Thy 1.2 monoclonal antibody linked to ricin is a potent cell-type-specific toxin.

1980 • 190 citations

Conjugation of Glucose Oxidase from Aspergillus niger and Rabbit Antibodies Using N-Hydroxysuccinimide Ester of N-(4-Carboxycyclohexylmethyl)-Maleimide

1979 • 181 citations

Selective killing of normal or neoplastic B cells by antibodies coupled to the A chain of ricin.

1980 • 168 citations

Modulation of human acute lymphoblastic leukemia antigen induced by monoclonal antibody in vitro.

1980 • 166 citations

Anti-T-Cell Reagents for Human Bone Marrow Transplantation: Ricin Linked to Three Monoclonal Antibodies

1983 • 148 citations

HLA-A2 as a target for cell-mediated lympholysis: Evidence from immunoselected HLA-A2 negative mutant cell lines

1980 • 131 citations

Cytotoxicity Acquired by Conjugation of an Anti‐Thy_1.1 Monoclonal Antibody and the Ribosome‐Inactivating Protein, Gelonin

1981 • 122 citations

Purification and partial characterization of another form of the antiviral protein from the seeds of Phytolacca americana L. (pokeweed)

1982 • 117 citations

Immunoglobulin secretion by cell lines derived from African and American undifferentiated lymphomas of Burkitt's and non-Burkitt's type.

1982 • 112 citations

Monoclonal antibody-ricin A chain conjugate selectively cytotoxic for cells bearing the common acute lymphoblastic leukemia antigen.

1982 • 111 citations

T lymphocyte surface antigens in primates

1983 • 108 citations

Pokeweed antiviral protein

1983 • 99 citations

Selective killing of malignant cells in a leukaemic rat bone marrow using an antibody–ricin conjugate

1982 • 98 citations

Synergy of ricin A chain-containing immunotoxins and ricin B chain-containing immunotoxins in in vitro killing of neoplastic human B cells.

1983 • 89 citations

Importance of the Antigen-Binding Valency and the Nature of the Cross-Linking Bond in Ricin A-Chain Conjugates with Antibody

1982 • 84 citations

Enhancement of toxicity of antitransferrin receptor antibody-Pseudomonas exotoxin conjugates by adenovirus.

1983 • 72 citations

Expression of a 26,000-dalton glycoprotein on activated human T cells

1981 • 70 citations

Comparison of the selective cytotoxic effects of immunotoxins containing ricin A chain or pokeweed antiviral protein and anti-Thy 1.1 monoclonal antibodies.

1984 • 60 citations

An immunotoxin with therapeutic potential in T cell leukemia: WT1-ricin A

1984 • 58 citations

Fate of a common acute lymphoblastic leukemia antigen during modulation by monoclonal antibody.

1981 • 55 citations

Seasonal variations in different forms of pokeweed antiviral protein, a potent inactivator of ribosomes.

1983 • 52 citations

Further Biochemical Studies of the Human B-Cell Differentiation Antigens B1 and B2

1983 • 52 citations

Disulfide crosslinking of Escherichia coli ribosomal proteins with 2-iminothiolane (methyl 4-mercaptobutyrimidate): evidence that the crosslinked protein pairs are formed in the intact ribosomal subunit

1978 • 47 citations

Herpesvirus ateles: Transformation in vitro of marmoset splenic lymphocytes

1974 • 46 citations

Divergen properties of two human lymphocytic cell lines isolated from a single specimen of peripheral blood

1974 • 45 citations

Properties of immunotoxins against a glycolipid antigen associated with Burkitt's lymphoma.

1984 • 38 citations

Monoclonal antibody that defines a unique human T-cell leukemia antigen

1983 • 36 citations

Anti-T cell monoclonal antibodies conjugated to ricin as potential reagents for human GVHD prophylaxis: effect on the generation of cytotoxic T cells in both peripheral blood and bone marrow.

1984 • 33 citations

Selective killing of target cells by antibody-ricin A chain or antibody-gelonin hybrid molecules: comparison of cytotoxic potency and use in immunoselection procedures.

1983 • 32 citations

The secretion of a sialic acid‐free immunoglobulin

1973 • 18 citations