Immunotoxins containing ricin

Coated pits, coated vesicles, and receptor-mediated endocytosis

1979 • 2,073 citations

Lysosomotropic agents

1974 • 1,887 citations

The Biochemistry of Glycoproteins and Proteoglycans

1980 • 1,231 citations

The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

1987 • 1,153 citations

The interaction of Ricinus communis agglutinin with normal and tumor cell surfaces

1972 • 514 citations

Characterization of two plant lectins from Ricinus communis and their quantitative interaction with a murine lymphoma

1974 • 470 citations

Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts.

1978 • 358 citations

Isolation and Comparison of Galactose-binding Lectins from Abrus precatorius and Ricinus communis

1974 • 341 citations

Role of coated vesicles, microfilaments, and calmodulin in receptor-mediated endocytosis by cultured B lymphoblastoid cells.

1980 • 315 citations

Toxic lectins and related proteins

1982 • 305 citations

Molecular Action of Toxins and Viruses

1982 • 298 citations

Nucleotide sequence of cloned cDNA coding for preproricin

1985 • 263 citations

Kinetics of binding of the toxic lectins abrin and ricin to surface receptors of human cells.

1976 • 238 citations

Therapy of patients with malignant melanoma using a monoclonal antimelanoma antibody-ricin A chain immunotoxin.

1987 • 212 citations

Kinetics of protein synthesis inactivation by ricin-anti-Thy 1.1 monoclonal antibody hybrids. Role of the ricin B subunit demonstrated by reconstitution.

1982 • 200 citations

Anti-Thy 1.2 monoclonal antibody linked to ricin is a potent cell-type-specific toxin.

1980 • 190 citations

Structure and evolution of ricin B chain

1987 • 188 citations

Carbohydrate Recognition Systems for Receptor-Mediated Pinocytosis

1980 • 184 citations

Immunotoxins: Hybrid Molecules Combining High Specificity and Potent Cytotoxicity

1982 • 181 citations

Mannose receptor-mediated uptake of ricin toxin and ricin A chain by macrophages. Multiple intracellular pathways for a chain translocation.

1986 • 167 citations

Purification of galactose-binding phytoagglutinins and phytotoxin by affinity column chromatography using sepharose

1972 • 162 citations

The Specificity and Action of Animal, Bacterial and Plant Toxins

1977 • 160 citations

Anti-T-Cell Reagents for Human Bone Marrow Transplantation: Ricin Linked to Three Monoclonal Antibodies

1983 • 148 citations

Effect of chemical deglycosylation of ricin A chain on the in vivo fate and cytotoxic activity of an immunotoxin composed of ricin A chain and anti-Thy 1.1 antibody.

1987 • 134 citations

Use of a novel colony assay to evaluate the cytotoxicity of an immunotoxin containing pokeweed antiviral protein against blast progenitor cells freshly obtained from patients with common B-lineage acute lymphoblastic leukemia.

1986 • 129 citations

Mechanism of cell entry and toxicity of an affinity- purified lectin from Ricinus communis and its differential effects on normal and virus-transformed fibroblasts.

1975 • 125 citations

Binding of galactose and lactose to ricin. Equilibrium studies

1978 • 115 citations

Monoclonal Antibody‐Ricin or Ricin A Chain Hybrids: Kinetic Analysis of Cell Killing for Tumor Therapy

1982 • 109 citations

Internalization and processing of the EGF receptor in the induction of DNA synthesis in cultured fibroblasts: The endocytic activation hypothesis

1979 • 100 citations

Ricin B chain is a product of gene duplication.

1981 • 100 citations

Selective killing of malignant cells in a leukaemic rat bone marrow using an antibody–ricin conjugate

1982 • 98 citations

Receptors and Recognition: Series A

1978 • 94 citations

Blockade of the galactose‐binding sites of ricin by its linkage to antibody

1984 • 93 citations

Binding of two molecules of 4-methylumbelliferyl galactose or 4-methylumbelliferyl N-acetylgalactosamine to the B chains of ricin and Ricinus communis agglutinin and to purified ricin B chain.

1982 • 89 citations

Synergy of ricin A chain-containing immunotoxins and ricin B chain-containing immunotoxins in in vitro killing of neoplastic human B cells.

1983 • 89 citations

Effects of therapy with T101 ricin A-chain immunotoxin in two leukemia patients

1986 • 89 citations

Studies on the galactose-binding site of ricin and the hybrid toxin man6P-ricin

1981 • 88 citations

Ricin subunit association. Thermodynamics and the role of the disulfide bond in toxicity.

1986 • 84 citations

Marrow purging in autologous bone marrow transplantation for T-lineage acute lymphoblastic leukemia: efficacy of ex vivo treatment with immunotoxins and 4-hydroperoxycyclophosphamide against fresh leukemic marrow progenitor cells

1987 • 82 citations

Use of multiple T cell-directed intact ricin immunotoxins for autologous bone marrow transplantation

1985 • 77 citations

Cloned fragment of diphtheria toxin linked to T cell-specific antibody identifies regions of B chain active in cell entry.

1986 • 76 citations

Ricin linked to monophosphopentamannose binds to fibroblast lysosomal hydrolase receptors, resulting in a cell-type-specific toxin.

1979 • 71 citations

Combined ex vivo treatment with immunotoxins and mafosfamid: a novel immunochemotherapeutic approach for elimination of neoplastic T cells from autologous marrow grafts.

1985 • 69 citations

A hybrid protein containing the toxic subunit of ricin and the cell-specific subunit of human chorionic gonadotropin. II. Biologic properties.

1979 • 69 citations

Bone marrow transplantation across major histocompatibility barriers. V. Protection of mice from lethal graft-vs.-host disease by pretreatment of donor cells with monoclonal anti-Thy-1.2 coupled to the toxin ricin.

1982 • 69 citations

Ricin B chain converts a non‐cytotoxic antibody‐ricin A chain conjugate into a potent and specific cytotoxic agent

1983 • 68 citations

Cytotoxicity of a cell-reactive immunotoxin containing ricin A chain is potentiated by an anti-immunotoxin containing ricin B chain.

1984 • 66 citations

Use of multiple T cell-directed intact ricin immunotoxins for autologous bone marrow transplantation

1985 • 57 citations

Synergy between immunotoxins prepared with native ricin A chains and chemically-modified ricin B chains.

1986 • 57 citations

Specific killing of lymphocytes that cause experimental autoimmune myasthenia gravis by ricin toxin-acetylcholine receptor conjugates.

1984 • 43 citations

Immunotoxins show rapid entry of diphtheria toxin but not ricin via the T3 antigen.

1986 • 43 citations

MONOCLONAL ANTIBODY-TOXIN CONJUGATES REACTIVE AGAINST HUMAN T LYMPHOCYTES

1984 • 41 citations

Whole ricin and recombinant ricin A chain idiotype-specific immunotoxins for therapy of the guinea pig L2C B cell leukemia.

1987 • 39 citations

A comparative study of ricin and diphtheria toxin-antibody-conjugate kinetics on protein synthesis inactivation.

1984 • 39 citations

Cytotoxic effect of anti-Mr 67,000 protein immunotoxins on human tumors in a nude mouse model.

1985 • 37 citations

Selective in vitro inhibition of an antibody response to purified acetylcholine receptor by using antigen-ricin A chain immunotoxin.

1985 • 37 citations

Cell-specific cytotoxicity expressed by a conjugate of ricin and murine monoclonal antibody directed against thy 1.1 antigen.

1981 • 37 citations

Zur Spezifit�t von Lektinen mit einem breiten Agglutinationsspektrum

1970 • 36 citations

Kinetics of protein synthesis inactivation in human T-lymphocytes by selective monoclonal antibody-ricin conjugates.

1985 • 35 citations

Combined immunochemotherapy of human solid tumors in nude mice.

1987 • 35 citations

Anti-T cell monoclonal antibodies conjugated to ricin as potential reagents for human GVHD prophylaxis: effect on the generation of cytotoxic T cells in both peripheral blood and bone marrow.

1984 • 33 citations

Selective abrogation of antigen-specific human B cell responses by antigen-ricin conjugates.

1982 • 32 citations

Elimination of clonogenic T-leukemic cells from human bone marrow using anti-Mr 65,000 protein immunotoxins.

1984 • 32 citations

Human Melanoma Cell Lines Showing Striking Inherent Differences in Sensitivity to Immunotoxins Containing Holotoxins<xref ref-type="fn" rid="FN2">2</xref>

1986 • 29 citations

Monoclonal antibodies in cancer : advances in diagnosis and treatment

1986 • 29 citations

B lymphocyte regulation of human hematopoiesis.

1985 • 26 citations

Selective killing of human bladder cancer cells by combined treatment with A and B chain ricin antibody conjugates.

1987 • 26 citations

Antigenic modulation by anti-CD5 immunotoxins.

1986 • 25 citations

On the specificity of lectins with a broad agglutination spectrum. I. The nature of the specific receptors for Ricinus communis and Solanum tuberosum Lectins.

1969 • 23 citations

Human leukemia cell binding and killing by anti-CD5 radioimmunotoxins

1987 • 15 citations

Selective killing of contaminating human fibroblasts in epithelial cultures derived from colorectal tumours using an anti Thy-1 antibody-ricin conjugate

1985 • 15 citations

Cytotoxic effects of anti-CD5 radioimmunotoxins on human tumors in vitro and in a nude mouse model.

1988 • 15 citations

Perspectives in toxicology*1

1966 • 15 citations

Kinetic comparison of ricin immunotoxins: biricin conjugate has potentiated cytotoxicity

1986 • 15 citations

Anti-CD2 (T, p50) intact ricin immunotoxins for GVHD-prophylaxis in allogeneic bone marrow transplantation

1986 • 14 citations

Sensitivity of target cells to immunotoxins: possible role of cell-surface antigens.

1985 • 10 citations

In vitro and in vivo cytotoxic activity of native and ricin conjugated monoclonal antibodies to HBs antigen for Alexander primary liver cell carcinoma cells and tumours.

1984 • 9 citations

THE EFFECTIVENESS OF ANTI-Ia-IMMUNOTOXINS IN THE SUPPRESSION OF MLR

1985 • 6 citations

Perspectives in Toxicology

1985 • 6 citations

ASSESSMENT OF IMMUNOCOMPETENCE BY LIMITING DILUTION ANALYSIS IN LONG-TERM T CELL DEPLETION CHIMERAS TRANSPLANTED ACROSS THE MHC BARRIER

1985 • 6 citations

Antibody-ricin conjugates: a method of linkage which blocks the galactose binding site of ricin.

1984 • 2 citations