Regulation of Insulin and Insulin-Like Growth Factor (IGF) Responsiveness by IGFs in Rat Hepatoma Cells*

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril

1978 • 4,673 citations

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Insulin resistance, insulin insensitivity, and insulin unresponsiveness: A necessary distinction

1978 • 784 citations

Insulin Receptor: Evidence That It Is a Protein Kinase

1983 • 413 citations

Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor.

1983 • 395 citations

A partially purified polypeptide fraction from rat liver cell conditioned medium with multiplication‐stimulating activity for embryo fibroblasts

1973 • 335 citations

Polypeptides with nonsuppressible insulin-like and cell-growth promoting activities in human serum: isolation, chemical characterization, and some biological properties of forms I and II.

1976 • 319 citations

Mechanisms of insulin resistance in obesity and noninsulin-dependent (type II) diabetes

1981 • 305 citations

Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells.

1984 • 260 citations

Stimulation of tyrosine-specific phosphorylation in vitro by insulin-like growth factor I

1983 • 254 citations

Effects of the somatomedins and insulin on myoblast differentiation in vitro

1981 • 189 citations

Defect in Phosphorylation of Insulin Receptors in Cells from an Insulin-Resistant Patient with Normal Insulin Binding

1984 • 167 citations

The high affinity insulin receptor mediates growth stimulation in rat hepatoma cells.

1982 • 152 citations

Insulin-induced loss of the insulin receptor in IM-9 lymphocytes. A biological process mediated through the insulin receptor.

1980 • 149 citations

Defect in insulin receptor phosphorylation in erythrocytes and fibroblasts associated with severe insulin resistance.

1984 • 146 citations

Insulin action rapidly modulates the apparent affinity of the insulin-like growth factor II receptor.

1983 • 132 citations

The role of antireceptor antibodies in stimulating phosphorylation of the insulin receptor.

1984 • 118 citations

Insulin Receptor Phosphorylation May Not Be a Prerequisite for Acute Insulin Action

1984 • 109 citations

Antireceptor antibodies as probes of insulinlike growth factor receptor structure.

1983 • 85 citations

Interactions between the receptors for insulin and the insulin-like growth factors on adipocytes.

1982 • 80 citations

Inhibition of intracellular proteolysis by insulin in isolated rat hepatocytes. Possible role of internalized hormone.

1982 • 77 citations

Polypeptide Hormones: Intracellular Receptors and Internalization

1981 • 77 citations

Insulin Receptors and Insulin Resistance

1983 • 77 citations

Intracellular Mediators of Insulin Action

1985 • 76 citations

Pseudoisozymes of Hepatic Tyrosine Aminotransferase

1974 • 55 citations

Desensitization of hepatoma cells to insulin action. Evidence for a post-receptor mechanism.

1981 • 55 citations

Insulin regulation of insulin-like growth factor action in rat hepatoma cells.

1984 • 44 citations

Insulin Receptor Regulation and Desensitization in Rat Hepatoma Cells: Concomitant Changes in Receptor Number and in Binding Affinity

1984 • 43 citations

Internalization and intracellular processing of insulin and insulin receptors in adipocytes

1982 • 40 citations

Abnormality of insulin binding and receptor phosphorylation in an insulin-resistant melanoma cell line.

1984 • 39 citations

Chemistry, structure, and function of insulin-like growth factors and their receptors: a review

1984 • 37 citations

Binding of nonsuppressible insulin‐like activity (NSILA) to isolated fat cells: Evidence for two separate membrane acceptor sites

1976 • 33 citations

New Perspectives on the Mechanism of Insulin Action

1984 • 33 citations

The insulin receptor and tyrosine protein kinase activity

1984 • 32 citations

Induction of tyrosine aminotransferase and amino acid transport in rat hepatoma cells by insulin and the insulin-like growth factor, multiplication-stimulating activity

1980 • 28 citations

Insulin resistance in H-35 rat hepatoma cells is mediated by post-receptor mechanisms

1983 • 16 citations