New Perspectives on the Mechanism of Insulin Action

Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.

1980 • 1,066 citations

Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.

1980 • 1,042 citations

Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity.

1980 • 853 citations

The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor.

1982 • 709 citations

Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system

1982 • 680 citations

Protein Phosphatases: Properties and Role in Cellular Regulation

1983 • 645 citations

Phosphorylation activates the insulin receptor tyrosine protein kinase.

1983 • 558 citations

Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity.

1981 • 456 citations

Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine.

1982 • 441 citations

Insulin Receptor: Evidence That It Is a Protein Kinase

1983 • 413 citations

Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor.

1983 • 395 citations

Insulin‐Like Growth Factors I and II: Some Biological Actions and Receptor Binding Characteristics of Two Purified Constituents of Nonsuppressible Insulin‐Like Activity of Human Serum

1978 • 384 citations

Demonstration of two subtypes of insulin-like growth factor receptors by affinity cross-linking.

1981 • 332 citations

Tyrosine-specific protein kinase activity is associated with the purified insulin receptor.

1983 • 324 citations

Electrophoretic resolution of three major insulin receptor structures with unique subunit stoichiometries.

1980 • 312 citations

Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta.

1982 • 287 citations

Purification of insulin receptor with full binding activity.

1983 • 273 citations

Insulin-stimulated tyrosine phosphorylation of the insulin receptor in detergent extracts of human placental membranes. Comparison to epidermal growth factor-stimulated phosphorylation.

1982 • 254 citations

Insulin receptor: covalent labeling and identification of subunits.

1979 • 243 citations

The structure of insulin receptor and its subunits. Evidence for multiple nonreduced forms and a 210,000 possible proreceptor.

1982 • 225 citations

Characterization of insulin-mediated phosphorylation of the insulin receptor in a cell-free system.

1983 • 223 citations

The .beta. subunit of the insulin receptor kinase is an insulin-activated protein

1983 • 219 citations

Biosynthesis and glycosylation of the insulin receptor. Evidence for a single polypeptide precursor of the two major subunits.

1983 • 216 citations

Receptor-mediated phosphorylation of the hepatic insulin receptor: Evidence that the M _r 95,000 receptor subunit is its own kinase

1983 • 213 citations

Structural similarities between human receptors for somatomedin C and insulin: analysis by affinity labeling

1981 • 187 citations

Insulin Receptor: Structure and Function

1981 • 187 citations

Receptors for Insulin, NSILA-s, and Growth Hormone: Applications to Disease States in Man

1975 • 174 citations

Activation of pyruvate dehydrogenase by direct addition of insulin to an isolated plasma membrane/mitochondria mixture: Evidence for generation of insulin's second messenger in a subcellular system

1980 • 172 citations

Insulin Action and the Regulation of Hexose Transport

1980 • 170 citations

A unique proteolytic cleavage site on the beta subunit of the insulin receptor.

1981 • 167 citations

beta-Adrenergic regulation of insulin and epidermal growth factor receptors in rat adipocytes.

1983 • 156 citations

The high affinity insulin receptor mediates growth stimulation in rat hepatoma cells.

1982 • 152 citations

Monensin blocks the maturation of receptors for insulin and somatomedin C: Identification of receptor precursors

1983 • 147 citations

Photoaffinity labeling of the human erythrocyte D-glucose transporter.

1982 • 147 citations

Membrane Sialic Acid and the Mechanism of Insulin Action in Adipose Tissue Cells

1971 • 144 citations

The subunit structure of rat liver insulin receptor. Antibodies directed against the insulin-binding subunit.

1980 • 144 citations

Role of disulfides in the subunit structure of the insulin receptor. Reduction of class I disulfides does not impair transmembrane signalling.

1982 • 140 citations

Somatomedin receptor of human placenta: solubilization, photolabeling, partial purification, and comparison with insulin receptor.

1981 • 136 citations

Insulin action rapidly modulates the apparent affinity of the insulin-like growth factor II receptor.

1983 • 132 citations

Equilibriums and kinetics of ligand binding to the human erythrocyte glucose transporter. Evidence for an alternating conformation model for transport

1981 • 132 citations

Phosphorylation of the hepatic insulin receptor

1982 • 126 citations

Affinity labeling of multiplication stimulating activity receptors in membranes from rat and human tissues.

1981 • 124 citations

Cytochalasin B. A natural photoaffinity ligand for labeling the human erythrocyte glucose transporter.

1982 • 110 citations

Detection of the rat adipose cell glucose transporter with antibody against the human red cell glucose transporter

1982 • 103 citations

Insulin receptor phosphorylation in intact adipocytes and in a cell-free system

1982 • 101 citations

Partial purification from rat adipocyte plasma membranes of a chemical mediator which simulates the action of insulin on pyruvate dehydrogenase.

1981 • 100 citations

Latent insulin receptors and possible receptor precursors in 3T3-L1 adipocytes.

1983 • 84 citations

Interactions between the receptors for insulin and the insulin-like growth factors on adipocytes.

1982 • 80 citations

Purification of an insulin-like growth factor II receptor from rat chondrosarcoma cells.

1983 • 78 citations

Photolabeling of glucose-sensitive cytochalasin B binding proteins in erythrocyte, fibroblast and adipocyte membranes

1982 • 73 citations

Immunological identification of the human erythrocyte glucose transporter.

1980 • 72 citations

Purification of the type II insulin-like growth factor receptor from rat placenta.

1983 • 71 citations

Hormone Binding Alters the Conformation of the Insulin Receptor

1980 • 70 citations

Insulin action

1981 • 67 citations

The insulin receptor: structural features

1981 • 65 citations

Identification of the stereospecific hexose transporter from starved and fed chicken embryo fibroblasts.

1982 • 62 citations

Structure of the insulin-like growth factor receptor in chicken embryo fibroblasts.

1982 • 60 citations

Phosphorylation—dephosphorylation of purified insulin receptor from human placenta

1982 • 56 citations

Identification of the glucose transporter in rat skeletal muscle

1983 • 54 citations

Multiplication stimulating activity (MSA) from the BRL 3A rat liver cell line: Relation to human somatomedins and insulin

1981 • 54 citations

β-Adrenergic dependent downregulation of insulin binding in rat adipocytes

1983 • 47 citations

Digestion of insulin receptors with proteolytic and glycosidic enzymes-effects on purified and membrane-associated receptor subunits

1980 • 46 citations

Regulation of cellular membrane transport by the exocytotic insertion and endocytic retrieval of transporters

1983 • 45 citations

The permeation of human red cells by 4, 6‐O‐ethylidene‐α‐D‐glucopyranose (ethylidene glucose)

1973 • 42 citations

Identification of the glucose transport protein of the microvillous membrane of human placenta by photoaffinity labelling

1982 • 38 citations

Parallel Decreases in the Expression of Receptors for Insulin and Insulin-like Growth Factor I in a Mutant Human Fibroblast Line

1983 • 26 citations

Actions of Insulin on Glucose Transport and cAMP Phosphodiesterase in Fat Cells: Involvement of Two Distinct Molecular Mechanisms

1983 • 19 citations

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