Resistance of Mitochondrial DNA-depleted Cells against Cell Death

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

1990 • 1,390 citations

Mitochondria, oxygen free radicals, disease and ageing

2000 • 1,054 citations

Role of superoxide dismutase in cancer: a review.

1979 • 976 citations

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

1982 • 893 citations

Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor

1998 • 887 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

Somatic mutations of the mitochondrial genome in human colorectal tumours

1998 • 828 citations

Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids

2000 • 808 citations

Detection of a specific mitochondrial DNA deletion in tissues of older humans

1990 • 784 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells.

1991 • 635 citations

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

1996 • 590 citations

Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1

1998 • 580 citations

Mechanisms of p53-dependent apoptosis

2001 • 542 citations

p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2

1999 • 479 citations

Mechanisms of p53-dependent apoptosis

2001 • 474 citations

Evidence that reactive oxygen species do not mediate NF- B activation

2003 • 385 citations

Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase.

1996 • 381 citations

The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase.

2000 • 324 citations

Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Plays a Major Role in Preventing Oxidative Injury to Cells

1999 • 296 citations

Manganese Superoxide Dismutase-Mediated Gene Expression in Radiation-Induced Adaptive Responses

2003 • 276 citations

Oxidative Damage and Mutation to Mitochondrial DNA and Age‐dependent Decline of Mitochondrial Respiratory Function^a

1998 • 257 citations

Tumor Necrosis Factor Alpha and Interleukin-1β Regulate the Murine Manganese Superoxide Dismutase Gene Through a Complex Intronic Enhancer Involving C/EBP-β and NF-κB

1997 • 231 citations

Regulation of reactive oxygen species-induced apoptosis and necrosis by caspase 3-like proteases

1998 • 216 citations

Age-dependent changes of antioxidant activities and markers of free radical damage in human skeletal muscle

1999 • 215 citations

Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA.

1996 • 202 citations

Glial cell type-specific responses to menadione-induced oxidative stress

2000 • 186 citations

Mitochondrial DNA determines the cellular response to cancer therapeutic agents

1999 • 180 citations

Reciprocal down-regulation of p53 and SOD2 gene expression–implication in p53 mediated apoptosis

2001 • 174 citations

Suppression of Leukotriene Formation in RBL-2H3 Cells That Overexpressed Phospholipid Hydroperoxide Glutathione Peroxidase

1998 • 168 citations

Superoxide-Mediated Cytotoxicity in Superoxide Dismutase-Deficient Fetal Fibroblasts

1997 • 167 citations

Stimulation by adriamycin of rat heart and liver microsomal NADPH-dependent lipid peroxidation

1981 • 166 citations

TheGpx1Gene Encodes Mitochondrial Glutathione Peroxidase in the Mouse Liver

1997 • 161 citations

Cytochrome c-mediated Apoptosis in Cells Lacking Mitochondrial DNA

1999 • 160 citations

Interferon γ (IFNγ) and Tumor Necrosis Factor α Synergism in ME-180 Cervical Cancer Cell Apoptosis and Necrosis

2001 • 132 citations

SOD2: A new type of tumor‐suppressor gene?

1992 • 132 citations

MnSOD Expression Is Increased in Metastatic Gastric Cancer

2000 • 129 citations

Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells.

2002 • 128 citations

Role of heme oxygenase-1 in the regulation of manganese superoxide dismutase gene expression in oxidatively-challenged astroglia

2000 • 124 citations

NF-κB-dependent MnSOD expression protects adenocarcinoma cells from TNF-α-induced apoptosis

2002 • 109 citations

Increases of Mitochondrial Mass and Mitochondrial Genome in Association with Enhanced Oxidative Stress in Human Cells Harboring 4,977 BP‐Deleted Mitochondrial DNA

2001 • 108 citations

Expression of manganese superoxide dismutase in esophageal and gastric cancers

1998 • 102 citations

Superoxide dismutases in relation to the overall survival of colorectal cancer patients

1998 • 98 citations

Excessive formation of hydroxyl radicals and aldehydic lipid peroxidation products in cultured skin fibroblasts from patients with complex I deficiency.

1997 • 96 citations

Stretch sensitivity of transmembrane mobility of hydrogen peroxide through voids in the bilayer. Role of cardiolipin.

1994 • 73 citations

Resistance of mitochondrial DNA-deficient cells to TRAIL: role of Bax in TRAIL-induced apoptosis

2002 • 69 citations

Untitled

2002 • 68 citations

Expression of Intercellular Adhesion Molecule 1 on Pancreatic β-Cells Accelerates β-Cell Destruction by Cytotoxic T-Cells in Murine Autoimmune Diabetes

1995 • 63 citations

Redox perturbations in cysteamine-stressed astroglia: Implications for inclusion formation and gliosis in the aging brain

1995 • 49 citations

The role of reactive oxygen species in adriamycin and menadione-induced glomerular toxicity

1998 • 38 citations

In Vivo ESR Spin Trapping Evidence for Hydroxyl Radical-Mediated Toxicity of Paraquat and Copper in Rats

1993 • 30 citations

The effects of the adenovirus-mediated wild-type p53 delivery in human epithelial ovarian cancer cell linein vitroandin vivo

1998 • 15 citations