The role of microtubule-based motor proteins in maintaining the structure and function of the Golgi complex

Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility

1985 • 1,930 citations

ER-to-Golgi transport visualized in living cells

1997 • 1,169 citations

Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts

1996 • 978 citations

Overexpression of the Dynamitin (p50) Subunit of the Dynactin Complex Disrupts Dynein-dependent Maintenance of Membrane Organelle Distribution

1997 • 652 citations

Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis.

1996 • 634 citations

A novel brain ATPase with properties expected for the fast axonal transport motor

1985 • 604 citations

A Complex of NuMA and Cytoplasmic Dynein Is Essential for Mitotic Spindle Assembly

1996 • 565 citations

Retrograde transport by the microtubule-associated protein MAP 1C

1987 • 547 citations

Visualization of ER-to-Golgi Transport in Living Cells Reveals a Sequential Mode of Action for COPII and COPI

1997 • 510 citations

Localization of cytoplasmic dynein to mitotic spindles and kinetochores

1990 • 508 citations

Golgi dispersal during microtubule disruption: regeneration of Golgi stacks at peripheral endoplasmic reticulum exit sites.

1996 • 498 citations

The subcellular organization of Madin-Darby canine kidney cells during the formation of a polarized epithelium.

1989 • 498 citations

Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein.

1991 • 482 citations

Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued.

1995 • 466 citations

Submolecular domains of bovine brain kinesin identified by electron microscopy and monoclonal antibody decoration

1989 • 460 citations

Cytoplasmic dynein-dependent vesicular transport from early to late endosomes [published erratum appears in J Cell Biol 1994 Feb;124(3):397]

1993 • 408 citations

Polarization of the Golgi apparatus and the microtubule-organizing center in cultured fibroblasts at the edge of an experimental wound.

1982 • 403 citations

Hindered diffusion of inert tracer particles in the cytoplasm of mouse 3T3 cells.

1987 • 395 citations

Dyneins: Molecular Structure and Cellular Function

1994 • 353 citations

Affinity Chromatography Demonstrates a Direct Binding between Cytoplasmic Dynein and the Dynactin Complex

1995 • 338 citations

Cytoplasmic dynein plays a role in mammalian mitotic spindle formation.

1993 • 335 citations

Two activators of microtubule-based vesicle transport.

1991 • 325 citations

Cytoplasmic dynein is a minus end-directed motor for membranous organelles

1989 • 313 citations

Microtubules and the organization of the Golgi complex

1985 • 311 citations

The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1).

1995 • 307 citations

Opposing motor activities are required for the organization of the mammalian mitotic spindle pole.

1996 • 301 citations

Identification of kinesin in sea urchin eggs, and evidence for its localization in the mitotic spindle

1985 • 301 citations

Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets.

1983 • 294 citations

Associations of elements of the Golgi apparatus with microtubules.

1984 • 291 citations

Cytoplasmic dynein participates in the centrosomal localization of the Golgi complex.

1992 • 279 citations

Targeting of Motor Proteins

1996 • 278 citations

Ultrastructural analysis of the dynactin complex: an actin-related protein is a component of a filament that resembles F-actin.

1994 • 275 citations

HISTOCHEMICAL AND ULTRASTRUCTURAL STUDIES ON HELA CELL CULTURES EXPOSED TO SPINDLE INHIBITORS WITH SPECIAL REFERENCE TO THE INTERPHASE CELL

1964 • 256 citations

Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic [published errata appear in J Cell Biol 1995 Mar;128(5):following 988 and 1995 May;129(3):893]

1995 • 243 citations

Role of microtubules in polarized delivery of apical membrane proteins to the brush border of the intestinal epithelium.

1989 • 240 citations

Molecular Requirements for Bi-directional Movement of Phagosomes Along Microtubules

1997 • 232 citations

Point mutation of adenosine triphosphate-binding motif generated rigor kinesin that selectively blocks anterograde lysosome membrane transport.

1995 • 230 citations

Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles.

1996 • 228 citations

Reclustering of scattered Golgi elements occurs along microtubules.

1989 • 228 citations

Tubulovesicular processes emerge from trans-Golgi cisternae, extend along microtubules, and interlink adjacent trans-Golgi elements into a reticulum

1990 • 227 citations

Mitotic Spindle Poles are Organized by Structural and Motor Proteins in Addition to Centrosomes

1997 • 220 citations

Identification of a microtubule-based cytoplasmic motor in the nematode C. elegans

1987 • 218 citations

Saccharomyces cerevisiae kinesin- and dynein-related proteins required for anaphase chromosome segregation.

1995 • 209 citations

Effect of microtubule assembly status on the intracellular processing and surface expression of an integral protein of the plasma membrane.

1984 • 209 citations

Molecular motors are differentially distributed on Golgi membranes from polarized epithelial cells.

1994 • 208 citations

Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles.

1996 • 203 citations

Microsurgical removal of centrosomes blocks cell reproduction and centriole generation in BSC-1 cells

1991 • 195 citations

Motors and membrane traffic

1997 • 187 citations

The response of the Golgi complex to microtubule alterations: the roles of metabolic energy and membrane traffic in Golgi complex organization.

1989 • 185 citations

Involvement of microtubule motors in basolateral and apical transport in kidney cells

1994 • 183 citations

Golgi spectrin: identification of an erythroid beta-spectrin homolog associated with the Golgi complex.

1994 • 178 citations

Identification of a small cytoplasmic ankyrin (AnkG119) in the kidney and muscle that binds beta I sigma spectrin and associates with the Golgi apparatus.

1996 • 168 citations

Motor proteins 1: kinesins.

1995 • 165 citations

Polarity of microtubules nucleated by centrosomes and chromosomes of Chinese hamster ovary cells in vitro

1980 • 155 citations

Kinesin-mediated organelle translocation revealed by specific cellular manipulations.

1994 • 152 citations

The Golgi apparatus remains associated with microtubule organizing centers during myogenesis.

1985 • 141 citations

Reassembly of Golgi stacks from mitotic Golgi fragments in a cell-free system.

1995 • 139 citations

CYTOPLASMIC MICROTUBULE-ASSOCIATED MOTORS

1993 • 137 citations

Association of kinesin with characterized membrane‐bounded organelles

1992 • 135 citations

Molecular genetics of kinesin light chains: generation of isoforms by alternative splicing.

1991 • 119 citations

Protein phosphatase 1 regulates the cytoplasmic dynein-driven formation of endoplasmic reticulum networks in vitro.

1995 • 114 citations

The carboxyl-terminal domain of kinesin heavy chain is important for membrane binding.

1994 • 110 citations

Molecular phylogeny of the kinesin family of microtubule motor proteins

1994 • 108 citations

Cytoplasmic microtubule-based motor proteins

1993 • 106 citations

Lytic granules from cytotoxic T cells exhibit kinesin-dependent motility on microtubules in vitro

1993 • 96 citations

Approximating the effects of diffusion on reversible reactions at the cell surface: ligand-receptor kinetics

1995 • 93 citations

Regulation of kinesin activity by phosphorylation of kinesin-associated proteins.

1994 • 90 citations

Cytoplasmic dynein undergoes intracellular redistribution concomitant with phosphorylation of the heavy chain in response to serum starvation and okadaic acid.

1994 • 88 citations

Movement of membrane tubules along microtubules in vitro: evidence for specialised sites of motor attachment

1994 • 85 citations

Molecular Motors and a Spectrin Matrix Associate with Golgi Membranes In Vitro

1997 • 84 citations

Association of kinesin with the Golgi apparatus in rat hepatocytes

1994 • 83 citations

Structure, function and regulation of cytoplasmic dynein

1994 • 79 citations

Scattered Golgi Elements during Microtubule Disruption Are Initially Enriched inTrans-Golgi Proteins

1998 • 74 citations

Motor proteins: A dynamic duo

1996 • 69 citations

Immunogold Localisation of the Intermediate Chain within the Protein Complex of Cytoplasmic Dynein

1996 • 58 citations

Biochemical and functional diversity of microtubule motors in the nervous system

1995 • 54 citations

Structure and function of dynactin

1996 • 53 citations

The Product of the Drosophila Gene, Glued, Is the Functional Homologue of the p150 Component of the Vertebrate Dynactin Complex

1996 • 50 citations

Microtubule translocation properties of intact and proteolytically digested dyneins from Tetrahymena cilia.

1989 • 50 citations

Microtubule depolymerization inhibits transport of cathepsin D from the Golgi apparatus to lysosomes

1990 • 47 citations

Phosphotransferases Associated with the Regulation of Kinesin Motor Activity

1997 • 45 citations

Membrane traffic motors

1995 • 40 citations

The Molecular Mechanism of Organelle Transport along Microtubules: The Identification and Characterization of Kifs (Kinesin Superfamily Proteins).

1996 • 39 citations

Kinesin localizes to the trans-Golgi network regardless of microtubule organization.

1996 • 34 citations

Targeting of Cytoplasmic Dynein to Membranous Organelles and Kinetochores via Dynactin

1995 • 27 citations

Movement of interphase Golgi apparatus in fused mammalian cells and its relationship to cytoskeletal elements and rearrangement of nuclei.

1990 • 27 citations

The role of microtubule-based motors in the exocytic transport of polarized cells

1996 • 26 citations

Dynein Structure And Function

1986 • 12 citations

Structural features involved in force generation in the kinesin superfamily.

1995 • 8 citations