Targeting of Motor Proteins

Brefeldin A: insights into the control of membrane traffic and organelle structure.

1992 • 1,848 citations

Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis.

1996 • 634 citations

MAP 1C is a microtubule-activated ATPase which translocates microtubules in vitro and has dynein-like properties.

1987 • 563 citations

Retrograde transport by the microtubule-associated protein MAP 1C

1987 • 547 citations

Localization of cytoplasmic dynein to mitotic spindles and kinetochores

1990 • 508 citations

Translocation and clustering of endosomes and lysosomes depends on microtubules.

1987 • 498 citations

Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells.

1990 • 488 citations

Cytoplasmic dynein is localized to kinetochores during mitosis

1990 • 486 citations

Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein.

1991 • 482 citations

Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued.

1995 • 466 citations

Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro

1985 • 463 citations

Cytoplasmic dynein-dependent vesicular transport from early to late endosomes [published erratum appears in J Cell Biol 1994 Feb;124(3):397]

1993 • 408 citations

Disruption of mitotic spindle orientation in a yeast dynein mutant.

1993 • 392 citations

Cytoplasmic dynein is required for normal nuclear segregation in yeast.

1993 • 373 citations

Actin-dependent organelle movement in squid axoplasm

1992 • 370 citations

CLIP-170 links endocytic vesicles to microtubules

1992 • 367 citations

The microtubule-dependent formation of a tubulovesicular network with characteristics of the ER from cultured cell extracts

1988 • 359 citations

Dyneins: Molecular Structure and Cellular Function

1994 • 353 citations

Cytoplasmic dynein is involved in nuclear migration in Aspergillus nidulans.

1994 • 352 citations

Evidence for alternating head catalysis by kinesin during microtubule-stimulated ATP hydrolysis.

1994 • 344 citations

Affinity Chromatography Demonstrates a Direct Binding between Cytoplasmic Dynein and the Dynactin Complex

1995 • 338 citations

Regulation of non-muscle myosin assembly by calmodulin-dependent light chain kinase

1980 • 338 citations

NudF, a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration.

1995 • 337 citations

Cytoplasmic dynein plays a role in mammalian mitotic spindle formation.

1993 • 335 citations

Two activators of microtubule-based vesicle transport.

1991 • 325 citations

Organization of organelles and membrane traffic by microtubules

1995 • 324 citations

The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1).

1995 • 307 citations

Cytoplasmic dynein and actin-related protein Arp1 are required for normal nuclear distribution in filamentous fungi.

1994 • 300 citations

Microtubule- and motor-dependent fusion in vitro between apical and basolateral endocytic vesicles from MDCK cells

1990 • 299 citations

Associations of elements of the Golgi apparatus with microtubules.

1984 • 291 citations

Immunofluorescence localization of the unconventional myosin, Myo2p, and the putative kinesin-related protein, Smy1p, to the same regions of polarized growth in Saccharomyces cerevisiae.

1994 • 290 citations

The centromere-kinetochore complex: a repeat subunit model.

1991 • 283 citations

Cytoplasmic dynein participates in the centrosomal localization of the Golgi complex.

1992 • 279 citations

Ultrastructural analysis of the dynactin complex: an actin-related protein is a component of a filament that resembles F-actin.

1994 • 275 citations

Microtubule-associated protein 1C from brain is a two-headed cytosolic dynein

1988 • 263 citations

Three distinct inner dynein arms in Chlamydomonas flagella: molecular composition and location in the axoneme.

1990 • 257 citations

Pathway of processive ATP hydrolysis by kinesin

1995 • 249 citations

Actin- and microtubule-dependent organelle motors: interrelationships between the two motility systems

1995 • 245 citations

Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic [published errata appear in J Cell Biol 1995 Mar;128(5):following 988 and 1995 May;129(3):893]

1995 • 243 citations

KIF3A is a new microtubule-based anterograde motor in the nerve axon.

1994 • 240 citations

Multiple nucleotide-binding sites in the sequence of dynein β heavy chain

1991 • 229 citations

Structural comparison of purified dynein proteins with in situ dynein arms

1984 • 225 citations

A yeast actin-related protein homologous to that in vertebrate dynactin complex is important for spindle orientation and nuclear migration

1994 • 223 citations

Kinectin, a major kinesin-binding protein on ER.

1992 • 215 citations

Saccharomyces cerevisiae kinesin- and dynein-related proteins required for anaphase chromosome segregation.

1995 • 209 citations

Molecular motors are differentially distributed on Golgi membranes from polarized epithelial cells.

1994 • 208 citations

Two different microtubule-based motor activities with opposite polarities in kinetochores

1991 • 202 citations

Involvement of microtubule motors in basolateral and apical transport in kidney cells

1994 • 183 citations

Differential phosphorylation in vivo of cytoplasmic dynein associated with anterogradely moving organelles.

1994 • 180 citations

WITH APOLOGIES TO SCHEHERAZADE: TAILS OF 1001 KINESIN MOTORS

1993 • 179 citations

BIK1, a protein required for microtubule function during mating and mitosis in Saccharomyces cerevisiae, colocalizes with tubulin.

1990 • 178 citations

Golgi spectrin: identification of an erythroid beta-spectrin homolog associated with the Golgi complex.

1994 • 178 citations

Four ATP-binding sites in the midregion of the β heavy chain of dynein

1991 • 175 citations

Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued

1991 • 174 citations

Phylogeny and expression of axonemal and cytoplasmic dynein genes in sea urchins.

1994 • 173 citations

Kinesin proteins: A phylum of motors for microtubule‐based motility

1996 • 172 citations

A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility

1992 • 168 citations

The 78,000 M(r) intermediate chain of Chlamydomonas outer arm dynein isa WD-repeat protein required for arm assembly.

1995 • 165 citations

Centractin is an actin homologue associated with the centrosome

1992 • 164 citations

Formation of membrane networks in vitro by kinesin-driven microtubule movement.

1988 • 163 citations

A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally.

1994 • 160 citations

A time-lapse video image intensification analysis of cytoplasmic organelle movements during endosome translocation.

1984 • 158 citations

Kinectin, an Essential Anchor for Kinesin-Driven Vesicle Motility

1995 • 158 citations

Identification of oda6 as a Chlamydomonas dynein mutant by rescue with the wild-type gene.

1991 • 158 citations

Bidirectional pigment granule movements of melanophores are regulated by protein phosphorylation and dephosphorylation

1986 • 157 citations

Drosophila cytoplasmic dynein, a microtubule motor that is asymmetrically localized in the oocyte.

1994 • 157 citations

Molecular analysis of the γ heavy chain of Chlamydomonas flagellar outerarm dynein

1994 • 152 citations

The Mr 78,000 intermediate chain of Chlamydomonas outer arm dynein interacts with alpha-tubulin in situ

1991 • 141 citations

CYTOPLASMIC MICROTUBULE-ASSOCIATED MOTORS

1993 • 137 citations

Regulation of cytoplasmic dynein function in vivo by the Drosophila Glued complex.

1995 • 130 citations

Dynein from Dictyostelium: primary structure comparisons between a cytoplasmic motor enzyme and flagellar dynein.

1992 • 129 citations

Immunolocalization of cytoplasmic dynein to lysosomes in cultured cells

1992 • 122 citations

Homology of the 74-kD cytoplasmic dynein subunit with a flagellar dynein polypeptide suggests an intracellular targeting function.

1992 • 120 citations

Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin

1993 • 120 citations

Identification and molecular evolution of new dynein-like protein sequences in rat brain

1995 • 117 citations

Localization of an intermediate chain of outer arm dynein by immunoelectron microscopy.

1990 • 117 citations

Molecular cloning of the retrograde transport motor cytoplasmic dynein (MAP 1C)

1993 • 117 citations

Effects of Kinesin Mutations on Neuronal Functions

1992 • 117 citations

Protein phosphatase 1 regulates the cytoplasmic dynein-driven formation of endoplasmic reticulum networks in vitro.

1995 • 114 citations

The carboxyl-terminal domain of kinesin heavy chain is important for membrane binding.

1994 • 110 citations

Phosphorylation of Neuronal Kinesin Heavy and Light Chains In Vivo

1993 • 110 citations

Chemical subdomains within the kinetochore domain of isolated CHO mitotic chromosomes.

1991 • 107 citations

Cytoplasmic microtubule-based motor proteins

1993 • 106 citations

ACT3: a putative centractin homologue in S. cerevisiae is required for proper orientation of the mitotic spindle.

1994 • 101 citations

The role of dynein in retrograde axonal transport

1989 • 101 citations

C. elegans osm-3 gene mediating osmotic avoidance behaviour encodes a kinesin-like protein

1993 • 100 citations

Cloning by insertional mutagenesis of a cDNA encoding Caenorhabditis elegans kinesin heavy chain.

1993 • 94 citations

Preparation of microtubules from rat liver and testis: Cytoplasmic dynein is a major microtubule associated protein

1989 • 93 citations

High-pressure liquid chromatography fractionation of Chlamydomonas dynein extracts and characterization of inner-arm dynein subunits

1987 • 91 citations

Regulation of kinesin activity by phosphorylation of kinesin-associated proteins.

1994 • 90 citations

A family of dynein genes in Drosophila melanogaster.

1994 • 90 citations

Cytoplasmic dynein undergoes intracellular redistribution concomitant with phosphorylation of the heavy chain in response to serum starvation and okadaic acid.

1994 • 88 citations

Kinesin and cytoplasmic dynein binding to brain microsomes.

1992 • 88 citations

Regulation of vesicle transport in CV-1 cells and extracts

1993 • 85 citations

Genetic Approaches to Molecular Motors

1992 • 80 citations

Characterization of DLC-A and DLC-B, two families of cytoplasmic dynein light chain subunits.

1994 • 80 citations

Molecular analysis of a cytoplasmic dynein light intermediate chain reveals homology to a family of ATPases

1995 • 78 citations

A kinetic study of the kinesin ATPase.

1992 • 72 citations

Cellular roles of kinesin and related proteins

1994 • 67 citations

Characterization of kinectin, a kinesin-binding protein: primary sequence and N-terminal topogenic signal analysis.

1995 • 66 citations

The primary structure of rat brain (cytoplasmic) dynein heavy chain, a cytoplasmic motor enzyme.

1993 • 65 citations

Cytoplasmic dynein is a vesicle protein.

1992 • 64 citations

New developments in understanding rapid axonal transport

1986 • 63 citations

Molecular cloning and characterization of human kinectin.

1995 • 48 citations

Structural and biochemical properties of kinesin heavy chain associated with rat brain mitochondria

1994 • 40 citations

Intracellular distribution of kinesin in chromaffin cells.

1994 • 28 citations

The primary structure of rat brain dynein heavy chain, a cytoplasmic motor enzyme

1993 • 24 citations

Genomic structure of a cytoplasmic dynein heavy chain gene from the nematode Caenorhabditis elegans

1995 • 20 citations

Chromosome distribution, molecular motors and the claret protein

1993 • 19 citations

Mechanism of axonal transport Identification of new molecular motors and regulations of transports

1993 • 17 citations

Microtubule-independent Phospholipid Stimulation of Cytoplasmic Dynein ATPase Activity

1995 • 11 citations